Caffeic acid phenolipids in the protection of cell membranes from oxidative injuries. Interaction with the membrane phospholipid bilayer

Lopes, Ricardo Ladeiras; Ferreira, Mariana; Gameiro, Paula; Fernandes, Sara; Catarino, Cristina; Santos-Silva, Alice; Paiva‐Martins, Fátima

doi:10.1016/j.bbamem.2021.183727

Cited by 19 publications

(9 citation statements)

References 42 publications

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“…The phenolic acids are distinguished via the existence of a benzene ring, a carboxylic acid group, and one/more hydroxyl/methoxy groups of the molecule that confers antioxidant functions ( 76 ). CA has been revealed for producing defensive results on α-tocopherol in low-density lipoprotein ( 77 , 78 ). CA is an antioxidant, which may decrease oxidative stress made in the body because of free radicals.…”

Section: Biological Mechanism Of Action Of Caffeic Acidmentioning

confidence: 99%

Therapeutic Implications of Caffeic Acid in Cancer and Neurological Diseases

et al. 2022

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Caffeic acid (CA) is found abundantly in fruits, vegetables, tea, coffee, oils, and more. CA and its derivatives have been used for many centuries due to their natural healing and medicinal properties. CA possesses various biological and pharmacological activities, including antioxidant, anti-inflammatory, anticancer, and neuroprotective effects. The potential therapeutic effects of CA are mediated via repression and inhibition of transcription and growth factors. CA possesses potential anticancer and neuroprotective effects in human cell cultures and animal models. However, the biomolecular interactions and pathways of CA have been described highlighting the target binding proteins and signaling molecules. The current review focuses on CA’s chemical, physical, and pharmacological properties, including antioxidant, anti-inflammatory, anticancer, and neuroprotective effects. We further described CA’s characteristics and therapeutic potential and its future directions.

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Section: Biological Mechanism Of Action Of Caffeic Acidmentioning

confidence: 99%

Therapeutic Implications of Caffeic Acid in Cancer and Neurological Diseases

et al. 2022

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“…Thymol [425] Natural polymers Lignin [426][427][428], Polyphenols [429], Cellulose [430,431], Polysialic acid [432] Gabaergic ketones Carvone, Menthone, Pulegone, Dihydrocarvone, Thujone [433] Taste and aroma Menthol [342,434], Terpenoids [435], Coumarin [132,284,436,437], Limonene [132], 4-ethylphenol (wine/beer aroma) [406], Tannins (wine) [438], Catechin [282] Caffeine and its derivatives Caffeine [132,439], Rosmarinic acid [440][441][442], Caffeic acid [441,443], Chlorogenic acid [441], Paraxanthine [132], Caffeic acid derivatives [444] Pigments Violacein [445,446], Marennine [447] Bile salts [280,423,448] Steroids Betulin [449], Saponins [450,451], Glycyrrhizic acid (saponin) [252,452,453], Withaferin-A and Withanone [454] Lipids N-arachidonylglycine and oleoyl-L-carnitine [137]...…”

Section: Antioxidantsmentioning

confidence: 99%

Mechanistic Understanding from Molecular Dynamics in Pharmaceutical Research 2: Lipid Membrane in Drug Design

2021

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We review the use of molecular dynamics (MD) simulation as a drug design tool in the context of the role that the lipid membrane can play in drug action, i.e., the interaction between candidate drug molecules and lipid membranes. In the standard “lock and key” paradigm, only the interaction between the drug and a specific active site of a specific protein is considered; the environment in which the drug acts is, from a biophysical perspective, far more complex than this. The possible mechanisms though which a drug can be designed to tinker with physiological processes are significantly broader than merely fitting to a single active site of a single protein. In this paper, we focus on the role of the lipid membrane, arguably the most important element outside the proteins themselves, as a case study. We discuss work that has been carried out, using MD simulation, concerning the transfection of drugs through membranes that act as biological barriers in the path of the drugs, the behavior of drug molecules within membranes, how their collective behavior can affect the structure and properties of the membrane and, finally, the role lipid membranes, to which the vast majority of drug target proteins are associated, can play in mediating the interaction between drug and target protein. This review paper is the second in a two-part series covering MD simulation as a tool in pharmaceutical research; both are designed as pedagogical review papers aimed at both pharmaceutical scientists interested in exploring how the tool of MD simulation can be applied to their research and computational scientists interested in exploring the possibility of a pharmaceutical context for their research.

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“…We speculate that this phenomenon may be due to Omega-Agatoxin IVA weakening the ability of RBCs to resist oxidative stress, which leads to crosstalk between calcium overload and ROS, aggravates cell damage and the inactivation of proteins and biologically active enzymes and causes the free calcium ion fluorescent tracer Fluo-4 AM not to be hydrolyzed by esterase. In addition, damage from ROS to the phospholipid component of the RBC membrane can also increase the permeability of the cell membrane and cause cell inactivation (49). In the 0.10 mM t-BHP treatment group, the ROS level in RBCs increased rapidly after 4 minutes and was greater than that of the control group without inhibitors.…”

Section: A B D Cmentioning

confidence: 94%

Exosomal MiR-4261 mediates calcium overload in RBCs by downregulating the expression of ATP2B4 in multiple myeloma

Bian

Zhang

et al. 2022

Front. Oncol.

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BackgroundHypercalcemia induced by multiple myeloma (MM) affects the biological functions of excitable and non-excitable cells. However, red blood cells (RBCs) regulatory effect on calcium in hypercalcemia is still not fully understood.MethodsA total of 113 patients with MM osteolytic lesions were studied retrospectively. Flow cytometry and atomic absorption spectroscopy were used to detect calcium content. Immunofluorescence and Western blotting were used to investigate protein expression. GEO and miRNA databases were used to screen miRNAs. Exosomal miR-4261 migration was investigated by Transwell assay. Dual-luciferase assays confirmed the targeting relationship between miR-4261 and ATP2B4. An RBC oxidative stress model was constructed, and Omega-Agatoxin IVA was used to study the role of plasma membrane Ca2+-ATPase 4 (PMCA4) in RBCs.ResultsThe results showed that MM RBCs had calcium overload, and serum calcium levels increased as the number of RBCs decreased. The expression of PMCA4 in MM RBCs was significantly lower than in normal RBCs. The exosomal miR-4261 produced by MM cells could be transferred to RBCs to downregulate the expression of ATP2B4.ConclusionsStudies have confirmed that RBCs experience calcium overload in MM with osteolytic lesions, which is related to the downregulation of ATP2B4 by MM exosomal miR-4261.

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Caffeic acid phenolipids in the protection of cell membranes from oxidative injuries. Interaction with the membrane phospholipid bilayer

Cited by 19 publications

References 42 publications

Therapeutic Implications of Caffeic Acid in Cancer and Neurological Diseases

Therapeutic Implications of Caffeic Acid in Cancer and Neurological Diseases

Mechanistic Understanding from Molecular Dynamics in Pharmaceutical Research 2: Lipid Membrane in Drug Design

Exosomal MiR-4261 mediates calcium overload in RBCs by downregulating the expression of ATP2B4 in multiple myeloma

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