Caffeic acid supplementation ameliorates intestinal injury by modulating intestinal microbiota in LPS-challenged piglets

Abstract

During weaning, piglets are susceptible to intestinal injuries caused by a range of infections, which has serious economic losses for pig production. Caffeic acid (CA) is a plant-derived phenolic acid...

Bacillus amyloliquefaciens SC06 Relieving Intestinal Inflammation by Modulating Intestinal Stem Cells Proliferation and Differentiation via AhR/STAT3 Pathway in LPS-Challenged Piglets

“…When administered through an intraperitoneal injection, LPS can directly interact with receptors of intestinal epithelial cells, stimulating the release of pro-inflammatory cytokines and triggering a cascade of events that ultimately result in barrier damage and epithelial cell death. 48,49 We discovered that SC06 decreased the rise in pro-inflammatory cytokine levels caused by LPS, which was consistent with prior findings in a mouse model. 50 Through the perception of diverse signals present in the intestinal milieu, intestinal macrophages possess the ability to modulate the inflammatory response through polarization toward either the M1 or M2 phenotype.…”

Integrated HS-GC–IMS and UPLC-Q-Orbitrap HRMS-based metabolomics revealed the characteristics and differential volatile and nonvolatile metabolites of different citrus peels

“… Wang et al, 2023 , Wang et al, 2023 , Wang et al, 2023 ). Caffeic acid and isoferulic acid can be used as characteristic metabolites to identify PK, and their supplementation can enhance intestinal integrity and barrier function by modulating the intestinal microbiota and its metabolites ( Jiang et al, 2020 ; Wen et al, 2023 ). Sinapinic acid alleviates acute pancreatitis in association ( Huang et al, 2022 ).…”

Cordyceps militaris Extract and Cordycepin Alleviate Oxidative Stress, Modulate Gut Microbiota and Ameliorate Intestinal Damage in LPS-Induced Piglets

“…The current experiment aimed to investigate the impact of LPS induction on intestinal inflammation in piglets. Therefore, we chose the same inflammatory indicators from similar studies to assess the effect of LPS induction on the intestinal inflammatory response in piglets [1,24]. The overexpression of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6 and IL-8) induces intestinal mucosal damage, alters intestinal epithelial permeability and triggers an inflammatory response [40].…”

“…In recent years, there has been an increased focus on the intestinal health of piglets due to the rapid growth of the animal husbandry industry. The intestine is the primary digestive and absorptive site and is also the largest immune organ, playing an essential role in maintaining normal immune defense function [1]. Intestinal health plays a crucial role in piglet growth and development, immune function and disease resistance.…”