Caffeic and Ferulic Acid Derivatives

Serafim, Teresa L.; Milhazes, Nuno; Borges, Fernanda; Oliveira, Paulo J.

doi:10.1016/b978-0-12-409517-5.00074-7

Cited by 9 publications

(8 citation statements)

References 51 publications

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“…CA exhibits a potent antiradical and antioxidant activity in breast tumors, acting by diverse mechanisms. It is a potential and practical clinical move toward presenting less toxicity for healthy cells and more action toward their malignant counterparts ( 133 ). CA decreases IL-12-making and NF-κB activation.…”

Section: Anticancer Effect Of Caffeic Acidmentioning

confidence: 99%

Therapeutic Implications of Caffeic Acid in Cancer and Neurological Diseases

et al. 2022

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Caffeic acid (CA) is found abundantly in fruits, vegetables, tea, coffee, oils, and more. CA and its derivatives have been used for many centuries due to their natural healing and medicinal properties. CA possesses various biological and pharmacological activities, including antioxidant, anti-inflammatory, anticancer, and neuroprotective effects. The potential therapeutic effects of CA are mediated via repression and inhibition of transcription and growth factors. CA possesses potential anticancer and neuroprotective effects in human cell cultures and animal models. However, the biomolecular interactions and pathways of CA have been described highlighting the target binding proteins and signaling molecules. The current review focuses on CA’s chemical, physical, and pharmacological properties, including antioxidant, anti-inflammatory, anticancer, and neuroprotective effects. We further described CA’s characteristics and therapeutic potential and its future directions.

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Section: Anticancer Effect Of Caffeic Acidmentioning

confidence: 99%

Therapeutic Implications of Caffeic Acid in Cancer and Neurological Diseases

et al. 2022

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“…Ot has been found in this research that the boiling water of potato contains phenolic compounds (phytonutrients) whose human health benefits have been demonstrated in several studies in vivo or in vitro: Chlorogenic acid (Cho et al, 2010;Sato et al, 2011;Shi et al, 2016), vanillin (Lirdprapamongkol et al, 2005) caffeic acid, coumarin and ferulic acid (Nasr Bouzaiene et al, 2015;Serafim et al, 2015) sinapic acid (Roy & Prince, 2012).…”

Section: Resultsmentioning

confidence: 79%

Phenolic compounds in native potato (Solanum tuberosum L.) cooking water, with potential antioxidant activity

et al. 2019

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For over two decades, there has been an increasing interest in finding natural antioxidants, because they can protect the human body from free radicals and retard the progress of many chronic diseases. Phenolic compounds were identified and quantified in potato cooking water from freeze-dried slices with peel and from whole potato stored for 20 days. Extracts were obtained with an aqueous solution composed of 50% methanol and 0.5% acetic acid. Fifteen secondary metabolites were monitored using the Ultra Performance Liquid Chromatography system coupled to mass spectrometry (UPLC-MS / MS). A calibration curve (from 0.1 ng to 100 μg) was generated and the data was analyzed using the software "MassHunter Workstation" VB 06.00, the results were expressed as mg/100 g of sliced potato or raw potato. Principal Components Analysis (PCA) was performed using XLSTAT 2015 Software. The potato cooking water contains phytonutrients with potential antioxidant activity to prevent non-transmissible degenerative diseases. The metabolite content in the cooking water of the Huagalina native potato is directly related to the freshness of the product before cooking. Potato cooking water could be considered a neutraceutical food. However, further research is required to identify any other substances that can be harmful to health depending on the amount consumed.

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“…CAPE is used as a dietary supplement in local medicine to treat a variety of ailments (Tolba, Azab, Khalifa, Abdel-Rahman, & Abdel-Naim, 2013), exerts its beneficial effects by decreasing free oxygen radicals and prevents the consumption of free radical scavenging enzymes by acting in parallel antioxidant enzymes (Ogeturk et al, 2005). CAPE, which is more biologically effective than other natural hydroxycinnamic acid derivatives due to its structural properties, has better bioavailability in lipophilic systems due to its distribution coefficient (Serafim, Milhazes, Borges, & Oliveira, 2015). CAPE is also the ester of caffeic acid, a derivative of phenolic acid (H.-C. Chen, Chen, Chang, & Shieh, 2011).…”

Section: Cape As Antioxidantmentioning

confidence: 99%

“…It is increasingly recognized that compounds containing phenolic groups that are considered potentially oncoprotective may be associated with positive effects on carcinogenesis, primarily due to their antioxidant activity. Since ROS play a role in tumor initiation and progression, antioxidants have attracted attention mainly due to their free radical scavenging activity (Serafim et al, 2015). The mechanisms of free radical scavenging of CAPE can be observed in Figures 3 and 4.…”

Section: Cape As Antioxidantmentioning

confidence: 99%

Caffeic acid phenethyl ester: A review on its pharmacological importance, and its association with free radicals, COVID‐19, and radiotherapy

Taysı

Algburi

Taysi

et al. 2022

Phytotherapy Research

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Caffeic acid phenethyl ester (CAPE), a main active component of propolis and a flavonoid, is one of the natural products that has attracted attention in recent years. CAPE, which has many properties such as anti‐cancer, anti‐inflammatory, antioxidant, antibacterial and anti‐fungal, has shown many pharmacological potentials, including protective effects on multiple organs. Interestingly, molecular docking studies showed the possibility of binding of CAPE with replication enzyme. In addition, it was seen that in order to increase the binding security of the replication enzyme and CAPE, modifications can be made at three sites on the CAPE molecule, which leads to the possibility of the compound working more powerfully and usefully to prevent the proliferation of cancer cells and reduce its rate. Also, it was found that CAPE has an inhibitory effect against the main protease enzyme and may be effective in the treatment of SARS‐CoV‐2. This review covers in detail the importance of CAPE in alternative medicine, its pharmacological value, its potential as a cancer anti‐proliferative agent, its dual role in radioprotection and radiosensitization, and its use against coronavirus disease 2019 (COVID‐19).

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Caffeic and Ferulic Acid Derivatives

Cited by 9 publications

References 51 publications

Therapeutic Implications of Caffeic Acid in Cancer and Neurological Diseases

Therapeutic Implications of Caffeic Acid in Cancer and Neurological Diseases

Phenolic compounds in native potato (Solanum tuberosum L.) cooking water, with potential antioxidant activity

Caffeic acid phenethyl ester: A review on its pharmacological importance, and its association with free radicals, COVID‐19, and radiotherapy

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