Caffeine is protective in patients with non‐alcoholic fatty liver disease

Abstract

SUMMARY BackgroundNon-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of metabolic syndrome, is the most common cause of primary liver disease. Although recent studies have found that coffee drinking is protective against end stage chronic liver disease, there are scarce caffeine intake data in NAFLD specifically.

The Effects of Dark Chocolate Consumption on Lipid Profile, Fasting Blood Sugar, Liver Enzymes, Inflammation, and Antioxidant Status in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized, Placebo-Controlled, Pilot study

“…Consequently, the potential therapies for NAFLD could focus on each one or more of these underlying factors [9] . Despite the rising incidence of NAFLD [5] , there is currently no satisfying therapeutic strategy (medical or surgical) for curing NAFLD [9] ; regards to the NAFLD propensity to induce end-stage liver disease suggests that early interventions could potentially prevent the more serious latter stage manifestations of this disease.…”

“…NAFLD defines as the excessive accumulation of fat deposits, primarily in the form of triglycerides in hepatocytes [3] , characterized by histologic features similar to alcoholic fatty liver disease [4] but in the absence of history of excessive alcohol consumption [5] , and encompasses a wide spectrum of liver conditions, from simple steatosis to nonalcoholic steatohepatitis (NASH), end-stage liver failure, and, ultimately, hepatocellular carcinoma [6] , which leads to liver-related death [7] .…”

A Mini Updated Review on the Role of Coffee in Non-Alcoholic Fatty Liver Disease

“…The second study came from the National Health and Nutrition Examination Surveys that enrolled 18,550 subjects. The authors concluded that 1782 individuals with NAFLD indicated caffeine intake as an inverse and independent predictor of NAFLD, suggesting a potential protective effect [13]. Molloy et al [14] aimed to evaluate the association of coffee and caffeine consumption with prevalence and severity of biopsy proven NAFLD.…”

Octopus (<i>Enterocopus dofleini</i>) Liver Extract Displays Triglyceride-Lowering Effect in HepG2 Cells

“…Dietary intake of fishes such as salmon, sardines, and trout, which are rich sources of omega-3 fatty acids, is known to protect the liver against fatty liver and hepatic steatohepatitis [5,6]. Caffeine intake is associated with a lower risk of fatty liver disease, suggestive of the potential protective role of caffeine [7]. Consumption of green tea rich in high-density catechins is shown to decrease liver fat content and inflammation in fatty liver disease [8].…”