Caffeine versus antioxidant combination (Antox) and their role in modifying cadmium‐induced testicular injury in adult male albino rats

Abstract

The unfavourable outcome of cadmium (Cd) on male fertility, sex hormones' production and sperm criteria have been reported in literature (Medina et al., 2017). Testicular tissue is particularly susceptible to cadmium-induced damage. Cd causes degeneration of rats' epididymis, seminal vesicles and spermatozoa (Sajjad et al., 2014). Cd, other heavy metals and oestrogenic-based compounds may explain the recent deterioration in male fertility in industrialised regions in the form of sperm count and testicular function reduction. This may involve the fact that Cd disrupts endocrine control of testicular tissue and induces oxidative damage (Siu et al., 2009). Cd exposure is linked with the generation of free radicals in acute toxicity and reactive oxygen species (ROS) in chronic toxicity. Cdgenerated superoxide anion, hydrogen peroxide and hydroxyl radicals have been reported and are usually associated with redox reactions and ROS-related genetic alterations. It is, therefore, stated that oxidative damage plays an integral part in cadmium toxicity (Liu et al., 2009). In rats subjected to prenatal Cd exposure, plasma testosterone concentrations are drastically lowered and expression of

Cadmium Toxicity in the Seminal Vesicles and Lipid Profile of Wistar Rats: Can Uvaria chamae Ameliorate the Effect?

“…Their study demonstrated that compounds with antioxidant and anti-inflammatory properties could effectively counteract the deleterious effects of cadmium. Uvaria chamae, with its well-documented antioxidant and anti-inflammatory effects [8,10], harmoniously aligns with the findings of Labib and Galal (2020) [7], positioning itself as a promising therapeutic agent at the microscopic level. Furthermore, the microscopic improvements witnessed in the seminal vesicles in the current study supports the outcomes of research conducted by Pamok (2018) [11].…”

“…Our findings gain enhanced significance when juxtaposed against related research. Labib and Galal (2020) [7] explored the realm of natural compounds and their potential to mitigate cadmium-induced reproductive toxicity. Their study demonstrated that compounds with antioxidant and anti-inflammatory properties could effectively counteract the deleterious effects of cadmium.…”

“…Drawing parallels with studies on other natural compounds fortifies the understanding of Uvaria chamae's mechanisms of action. Labib and Galal (2020) [7] and Pamok (2018) [11] have illuminated the centrality of antioxidant and anti-inflammatory mechanisms in countering heavy metal-induced damage. The congruence of findings across these studies underscores the collective importance of these molecular pathways in the ameliorating arsenal of natural compounds against environmental toxicants.…”

“…Cadmium toxicity can damage the seminal vesicles, leading to decreased sperm production and quality [6]. Any disruption in seminal vesicle structure or function can profoundly impact reproduction processes, potentially causing fertility issues and reproductive disorders [7]. Uvaria chamae, also known as bush banana or finger root, is a plant native to various parts of Africa, traditionally used due to its medicinal properties [8].…”

Caffeine attenuates spermatogenic disorders in mice with induced chronic scrotal hyperthermia

“…In the present study, we observed that all evaluated sperm characteristics, including count, viability, motility, and morphology, were significantly superior in the preventive and curative groups compared to the other groups. Numerous studies have highlighted the anti-inflammatory, anticancer, and antioxidant properties of caffeine, even suggesting its potential as a preventative measure against the effects of various drugs and environmental factors on fertility and testicular tissue [ 15 , 31 , 45 , 46 ]. Our findings indicate that caffeine mitigates the tissue damage induced by chronic hyperthermia in testicular tissue.…”