Caine Intestinal Carcinoids

Sykes, Greg P.; Cooper, Barry

doi:10.1177/030098588201900203

Cited by 33 publications

(22 citation statements)

References 17 publications

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“…Animals with carcinoids can have a variety of clinical findings, or in some cases benign carcinoids have been found incidentally in the lung or intestine of clinically healthy animals during physical exam or imaging studies (Choi et al, 2008;Sykes and Cooper, 1982). Clinical signs generally reflect the anatomic location of the lesion.…”

Section: Carcinoidsmentioning

confidence: 99%

Endocrine/Neuroendocrine System

Choi¹,

Arndt²

2016

Canine and Feline Cytology

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Section: Carcinoidsmentioning

confidence: 99%

Endocrine/Neuroendocrine System

Choi¹,

Arndt²

2016

Canine and Feline Cytology

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“…21,51 Localized amyloid deposits with or without association with neoplasia also have been described in the human mammary gland, 41,52 respiratory tract, 26,34 gastrointestinal tract, 5,38 genitourinary tract, 13,17 skin, 24,25 and bone. 23 In animals, localized amyloidosis has been associated with neoplastic conditions such as calcifying epithelial odontogenic tumor (CEOT), 2,29 pancreatic endocrine tumor, 28 medullary thyroid carcinoma, 15 ameloblastoma, 10 mammary carcinoma, 43 intestinal carcinoid, 40 extramedullary plasmacytoma, 31,36 and myeloma. 12 CEOT is a rare neoplasm of the tooth-forming apparatus that produces a mineralized substance and amyloid.…”

mentioning

confidence: 99%

Biochemical and Immunohistochemical Characterization of the Amyloid in Canine Amyloid-Producing Odontogenic Tumor

Hirayama

Miyasho

Ohmachi³

et al. 2010

Vet Pathol

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The amyloid of canine amyloid-producing odontogenic tumor (APOT) was evaluated biochemically and immunohistochemically. The N-terminal amino-acid sequence of purified amyloid protein from a canine APOT was strikingly similar to the sequence in both rat ameloblastin and porcine sheathlin. Immunohistochemically, the amyloid in APOT from 9 dogs was strongly reactive with anti-rat ameloblastin, anti-porcine sheathlin, and anti-canine APOT amyloid and weakly reactive with anti-porcine amelogenin but negative for antibodies to cytokeratins, vimentin, desmin, a-smooth muscle actin, amyloid A, glial fibrillary acidic protein, or S100 protein. The neoplastic epithelial cells of APOT were focally reactive with antibodies to ameloblastin, sheathlin, amelogenin, and canine APOT amyloid. The similarity in amino-acid sequence of the amyloid protein of canine APOT to that of enamel proteins, such as ameloblastin, sheathlin, and amelogenin, and the expression of these antigens in both APOT amyloid and in the neoplastic cells suggest that the amyloid of canine APOT is derived from enamel proteins secreted by ameloblasts. Keywords ameloblasts, amyloid, dogs, enamel proteins, odontogenic tumorAmyloidosis is a heterogeneous group of disorders characterized by the deposition of amyloid proteins derived from any of at least 25 different precursor molecules. Amyloid is considered a pathologic substance that appears histologically as an extracellular, amorphous, congophilic protein with applegreen birefringence under polarized light. Amyloidosis can be categorized as systemic or localized. Common human types of localized amyloidosis include amyloidosis of endocrine organs associated (or not) with neoplastic conditions and cerebral amyloidosis of Alzheimer's disease. 21,51 Localized amyloid deposits with or without association with neoplasia also have been described in the human mammary gland, 41,52 respiratory tract, 26,34 gastrointestinal tract, 5,38 genitourinary tract, 13,17 skin, 24,25 and bone. 23 In animals, localized amyloidosis has been associated with neoplastic conditions such as calcifying epithelial odontogenic tumor (CEOT), 2,29 pancreatic endocrine tumor, 28 medullary thyroid carcinoma, 15 ameloblastoma, 10 mammary carcinoma, 43 intestinal carcinoid, 40 extramedullary plasmacytoma, 31,36 and myeloma. 12 CEOT is a rare neoplasm of the tooth-forming apparatus that produces a mineralized substance and amyloid. 30 The origin of the amyloid in human and animal CEOT is often debated but is still unknown. 2,19,27,29,37,42,46 Recent studies indicate that the amyloid in human CEOT is secreted by the neoplastic epithelial cells, but its precise nature remains unclear. 27,39,42 CEOT in veterinary medicine is classified as amyloidproducing odontogenic tumor (APOT). 9,14 In the present study, we partially sequenced the amino acids of the major amyloid protein of canine APOT and compared the amino-terminal sequence with that of the enamel proteins rat ameloblastin and porcine sheathlin, which are transcribed in cells of the epi...

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“…2 In dogs, hepatic, gastrointestinal, and pulmonary carcinoids have been reported. [5][6][7] Intestinal carcinoids have also been documented in a horse and a cow. 2 In horses, three cases of maxillary sinus carcinoid tumors have been reported as well.…”

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A Carcinoid Tumor in the Gallbladder of a Dog

Morrell¹,

Volk²,

Mankowski³

2002

Vet Pathol

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Abstract.A cholecystectomy was performed on a 10-year-old spayed female mixed-breed dog with chronic weight loss, persistently increased liver enzyme activities, and cholecystomegaly identified by ultrasonographic examination. A subsequent diagnosis of a biliary carcinoid was made based on a neuroendocrine-type histologic pattern, cytoplasmic argyrophilia by Grimelius staining, immunopositivity for chromogranin A, and the ultrastructural finding of cytoplasmic secretory granules in neoplastic cells. Extrahepatic biliary carcinoid tumors are rare tumors of humans and have not been documented in domestic animals.Key words: Dogs; gallbladder; biliary; carcinoid. In humans and animals, carcinoid tumors are uncommon neoplasms that arise from dispersed cells of the neuoroendocrine system in the gastrointestinal tract, biliary system, pancreas, and lung. These cells belong to one of two functional groups: 1) the amine precursor uptake and decarboxylation cells that produce serotonin and adrenocorticotrophic hormone, or 2) those cells capable of synthesizing low molecular weight polypeptide or protein hormones such as chromogranin, cholecystokinin and secretin. Definitive diagnosis of carcinoid tumors is based on histologic features, immunostaining for secretory products such as chromogranin, and ultrastructural identification of neuroendocrine secretory granules. 2 In dogs, hepatic, gastrointestinal, and pulmonary carcinoids have been reported. [5][6][7] Intestinal carcinoids have also been documented in a horse and a cow. 2 In horses, three cases of maxillary sinus carcinoid tumors have been reported as well. 8 In humans, carcinoid tumors are frequently found in the gastrointestinal system (74%) and the bronchopulmonary system (25%). Within the gastrointestinal tract, the most common sites include the small bowel (29%), appendix (19%), and rectum (13%). 3 In this case, a 10-year-old spayed female mixed-breed dog initially presented for weight loss and persistent vomition. No abnormalities were noted on physical examination. Serum biochemistry abnormalities included increased liver enzyme activities, including aspartate aminotransferase (625 U/ L; reference range 10-60 U/L), alanine aminotransferase (2,225 U/L; reference range 8-57 U/L), lactate dehydrogenase (531 U/L; reference range (0-250 U/L), and alkaline phosphatase (4,460 U/L; reference range 10-140 U/L) as well as hyperbilirubinemia (Total bilirubin 5.6 mg/dL; reference range 0-0.6 mg/dL) consistent with hepatocellular damage and cholestasis. During the next 8 weeks, progres-

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Caine Intestinal Carcinoids

Cited by 33 publications

References 17 publications

Endocrine/Neuroendocrine System

Endocrine/Neuroendocrine System

Biochemical and Immunohistochemical Characterization of the Amyloid in Canine Amyloid-Producing Odontogenic Tumor

A Carcinoid Tumor in the Gallbladder of a Dog

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