Cajanolactone A, a stilbenoid from cajanus cajan, prevents ovariectomy-induced obesity and liver steatosis in mice fed a regular diet

Luo, Zhihan; Liu, Zhiwen; Mao, Yu; Shu, Rong; Fu, Lin-Chun; Yang, Rui-Yi; Hu, Yingjie; Shen, Xiaoling

doi:10.1016/j.phymed.2020.153290

Cited by 11 publications

(2 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, we observed higher Fabp3 levels in the ASO group compared to the Control group, aligning with previous findings 37 , indicating that the administration of ASO may improve the in vivo utilization rate of FAs. Furthermore, our results revealed elevated expression of Acsm5 in the ASO group compared to the Control group, which catalyzes the FAs by CoA to produce acyl-CoA as the first step in FAs metabolism 38 (Supplementary Fig. 2e ).…”

Section: Discussionmentioning

confidence: 68%

Multi-omics reveal neuroprotection of Acer truncatum Bunge Seed extract on hypoxic-ischemia encephalopathy rats under high-altitude

Chen,

Song,

Song

et al. 2023

Commun Biol

View full text Add to dashboard Cite

Hypoxic-ischemic encephalopathy (HIE) at high-altitudes leads to neonatal mortality and long-term neurological complications without effective treatment. Acer truncatum Bunge Seed extract (ASO) is reported to have effect on cognitive improvement, but its molecular mechanisms on HIE are unclear. In this study, ASO administration contributed to reduced neuronal cell edema and improved motor ability in HIE rats at a simulated 4500-meter altitude. Transcriptomics and WGCNA analysis showed genes associated with lipid biosynthesis, redox homeostasis, neuronal growth, and synaptic plasticity regulated in the ASO group. Targeted and untargeted-lipidomics revealed decreased free fatty acids and increased phospholipids with favorable ω-3/ω-6/ω-9 fatty acid ratios, as well as reduced oxidized glycerophospholipids (OxGPs) in the ASO group. Combining multi-omics analysis demonstrated FA to FA-CoA, phospholipids metabolism, and lipid peroxidation were regulated by ASO treatment. Our results illuminated preliminary metabolism mechanism of ASO ingesting in rats, implying ASO administration as potential intervention strategy for HIE under high-altitude.

show abstract

Section: Discussionmentioning

confidence: 68%

Multi-omics reveal neuroprotection of Acer truncatum Bunge Seed extract on hypoxic-ischemia encephalopathy rats under high-altitude

Chen,

Song,

Song

et al. 2023

Commun Biol

View full text Add to dashboard Cite

show abstract

“…The combination of imaging techniques and proteomic analysis has allowed for the identification of abnormalities in axonal or vascular damage markers, metabolic anomalies, and mechanisms underlying brain injury or atrophy (Herman et al 2018 ; Wright et al 2019 ).Proteomic analysis in conjunction with postoperative MRI imaging has shown a correlation between levels of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) with clinical outcomes, ventricular dysfunction, and pulmonary artery remodeling (Schafer et al 2021 ). In addition, imaging techniques like MRI and CT can provide information about the body's fat compositions, and by combining imaging results with proteome analysis, potential agents like Cajanolactone A have been identified for preventing postmenopausal obesity and fatty liver (Luo et al 2020 ). Machine learning has been utilized to non-alcoholic fatty liver disease (NAFLD) and identify biological players in liver fat accumulation (Atabaki-Pasdar et al 2020 ).…”

Section: Applicationsmentioning

confidence: 99%

Phenomic Imaging

Lan,

Feng,

et al. 2023

Phenomics

View full text Add to dashboard Cite

Human phenomics is defined as the comprehensive collection of observable phenotypes and characteristics influenced by a complex interplay among factors at multiple scales. These factors include genes, epigenetics at the microscopic level, organs, microbiome at the mesoscopic level, and diet and environmental exposures at the macroscopic level. “Phenomic imaging” utilizes various imaging techniques to visualize and measure anatomical structures, biological functions, metabolic processes, and biochemical activities across different scales, both in vivo and ex vivo. Unlike conventional medical imaging focused on disease diagnosis, phenomic imaging captures both normal and abnormal traits, facilitating detailed correlations between macro- and micro-phenotypes. This approach plays a crucial role in deciphering phenomes. This review provides an overview of different phenomic imaging modalities and their applications in human phenomics. Additionally, it explores the associations between phenomic imaging and other omics disciplines, including genomics, transcriptomics, proteomics, immunomics, and metabolomics. By integrating phenomic imaging with other omics data, such as genomics and metabolomics, a comprehensive understanding of biological systems can be achieved. This integration paves the way for the development of new therapeutic approaches and diagnostic tools.

show abstract

Identification of a novel pathogenic gene, NDUFA3, in Leigh Syndrome through whole exome sequencing

Li,

Wu,

Wang

et al. 2024

Neurogenetics

View full text Add to dashboard Cite

Background Leigh syndrome is a common mitochondrial disorder caused by gene mutations in the nucleus and mitochondria. When building mitochondrial complex I, the main subunit ND1 combines with the Q module to form a 273 kDa complex, which then adds Ndufa3 , Ndufa8 , and Ndufa13 to create an intermediate product of about 283 kDa called Q/Pp-a. Although Ndufa8 and Ndufa13 have been linked to mitochondrial diseases, the role of Ndufa3 in disease development is still not fully understood. Methods A family suspected of having Leigh syndrome was examined. Subjects (two brothers and a sister) underwent brain imaging, and their clinical symptoms were evaluated. Also, whole exome sequencing and minigene testing were performed by examining peripheral blood samples (2 ml) collected from the proband, his parents, and brothers. Results Three affected children showed early-onset symptoms, including abnormalities in muscle tone and delayed motor and language development. Symptoms were relatively mild. The second child of the second pregnancy experienced worsened muscle tone abnormalities after injury, slow wound healing, and sustained increased muscle tone up to a year after wound closure. His brain scans revealed lesions in the basal ganglia and brainstem, consistent with Leigh syndrome diagnosis. Genetic analysis identified compound heterozygous mutations in the Ndufa3 gene in all affected family members. Conclusion This is the first report of a family affected by Leigh syndrome associated with mutations in the Ndufa3 gene. Our analyses of clinical symptoms, radiological scans, and genetic investigations broaden our understanding of Ndufa3 gene mutations and their role in the development of Leigh syndrome. Supplementary Information The online version contains supplementary material available at 10.1007/s10048-024-00782-8.

show abstract

Cajanolactone A, a stilbenoid from cajanus cajan, prevents ovariectomy-induced obesity and liver steatosis in mice fed a regular diet

Cited by 11 publications

References 29 publications

Multi-omics reveal neuroprotection of Acer truncatum Bunge Seed extract on hypoxic-ischemia encephalopathy rats under high-altitude

Multi-omics reveal neuroprotection of Acer truncatum Bunge Seed extract on hypoxic-ischemia encephalopathy rats under high-altitude

Phenomic Imaging

Identification of a novel pathogenic gene, NDUFA3, in Leigh Syndrome through whole exome sequencing

Contact Info

Product

Resources

About