Calcarine as a bridge between brain function and structure in irritable bowel syndrome: A multiplex network analysis

Abstract

Background and Aim Jointly analyzing structural and functional brain networks enables a better understanding of pathological underpinnings of irritable bowel syndrome (IBS). Multiplex network analysis provides a novel framework to study complex networks consisting of different types of connectivity patterns in multimodal data. Methods In the present work, we integrated functional and structural networks to a multiplex network. Then, the multiplex metrics and the inner‐layer/inter‐layer hub nodes were investigated through 34 patients with IBS and 33 healthy controls. Results Significantly differential multiplex degree in both left and right parts of calcarine was found, and meanwhile, IBS patients lost inner‐layer hub properties in these regions. In addition, the left fusiform was no longer practicing as an inner‐layer hub node, while the right median cingulate acted as a new inner‐layer hub node in the IBS patients. Besides, the right calcarine, which lost its inner‐layer hub identity, became a new inter‐layer hub node, and the multiplex degree of the left hippocampus, which lost its inter‐layer hub identity in IBS patients, was significantly positively correlated with the IBS Symptom Severity Score scores. Conclusions Inner‐layer hub nodes of multiplex networks were preferentially vulnerable, and some inner‐layer hub nodes would convert into inter‐layer hub nodes in IBS patients. Besides, the inter‐layer hub nodes might be influenced by IBS severity and therefore converted to general nodes.

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