Calcifying synovial sarcoma of the tongue with SS18 rearrangement: a rare variant in a rare location

Alabdulaaly, Lama; Aldawood, Zahra; Afshar, Salim; Rahbar, Reza; Al‐Ibraheemi, Alyaa; Woo, Sook‐Bin

doi:10.1016/j.oooo.2020.08.016

Cited by 3 publications

(6 citation statements)

References 33 publications

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“…Common signs and symptoms of SS of the tongue include pain in the tongue area, eating difficulties, loss of ability to speak, inability to close lips, hoarseness, frequent choking, sore throat, fever, and swelling. Most cases reported in Table 2 are biphasic subtypes than monophasic, and very few cases are of calcifying SS (Alabdulaaly et al, 2021). In our review, the first case in the tongue area is a monophasic and calcifying subtype (Alabdulaaly et al, 2021).…”

Section: Synovial Sarcoma In Laryngeal and Pharyngeal Regionsmentioning

confidence: 68%

“…Most cases reported in Table 2 are biphasic subtypes than monophasic, and very few cases are of calcifying SS (Alabdulaaly et al, 2021). In our review, the first case in the tongue area is a monophasic and calcifying subtype (Alabdulaaly et al, 2021). Due to its rarity, diagnosis of the disease is complicated disease.…”

Section: Synovial Sarcoma In Laryngeal and Pharyngeal Regionsmentioning

confidence: 80%

“…Figure 1 shows hematoxylin and eosin staining of the three histologic variants of SS. Other variants include myxoid SS and ossifying/calcifying SS (Shukla et al, 2003;Alabdulaaly et al, 2021). Monophasic SS contains uniform spindle cells, biphasic SS consists of epithelial cells arranged into glandular structures with spindle cells arranged into fascicles, and spindles and round blue cells characterize poorly differentiated SS (Jayasooriya et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

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Synovial sarcoma of the head and neck: A review of reported cases on the clinical characteristics and treatment methods

Quan

Sreekissoon²,

Wang³

2023

Front. Cell Dev. Biol.

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Synovial sarcoma (SS) is a high-grade soft-tissue sarcoma that occurs predominantly in older children and young adults in their thirties. It is usually very challenging to diagnose and treat synovial sarcoma in the head and neck region. The purpose of this review is to investigate the clinical manifestations and different treatment methods in the management of primary synovial sarcoma of the head and neck. HNSS has an aggressive nature and poor prognosis. Surgical resection, radiotherapy, and chemotherapy are the primary treatment methods. Typically, surgical resection with negative margins remains the foundation of therapy, which is not very easily achieved in the head and neck due to its complex anatomical structure and the presence of many blood vessels and nerves. However, synovial sarcoma has a high recurrence rate, so aggressive management and close follow-up are warranted for the optimal outcome.

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Section: Synovial Sarcoma In Laryngeal and Pharyngeal Regionsmentioning

confidence: 68%

Section: Synovial Sarcoma In Laryngeal and Pharyngeal Regionsmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Synovial sarcoma of the head and neck: A review of reported cases on the clinical characteristics and treatment methods

Quan

Sreekissoon²,

Wang³

2023

Front. Cell Dev. Biol.

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“…In contrast to SS, MPNST shows an intact SMARCB1 and reveals H3 K27 me3 loss. SFT demonstrates hyper-and hypocellularity zones rather than the uniform herringbone pattern of SS and is positive for CD34 and STAT-6 [9]. In addition, the monophasic variant is similar to fibrosarcoma, but it shows no reactivity with epithelial markers [6].…”

Section: Discussionmentioning

confidence: 99%

“…The differential diagnosis for monophasic SS comprises leiomyosarcoma, malignant peripheral nerve sheath tumor (MPNST), and solitary fibrous tumor (SFT). Leiomyosarcoma shows spindle cells with abundant eosinophilic cytoplasm; blunt-ended nuclei, cytoplasmic vacuoles; nuclear atypia, and mitotic figures [9]. Immunohistochemical analysis usually shows the presence of desmin, muscle-specific actin, and SMA [10].…”

Section: Discussionmentioning

confidence: 99%

Primary synovial sarcoma of mandibular gingiva: An exceedingly rare case report

Shirafkan¹,

Atarbashi-Moghadam²,

Razavi³

et al. 2021

Otorhinolaryngol Head Neck Surg

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Synovial sarcoma is a soft tissue sarcoma that rarely occurs in the oral cavity and the most common site is the tongue. Synovial sarcoma of the oral cavity mostly presents as a slowly growing, painless, and deeply seated mass. Radical surgical excision with negative margins is the treatment of choice and adjuvant radiotherapy is advised. This report presents a 48-year-old male patient with a rapidly growing mandibular gingival mass with underlying alveolar bone destruction. Incisional biopsy was done, and the specimen was stained with Hematoxylin and Eosin. Microscopic sections showed fascicles of proliferated spindle-shaped cells with plump nuclei that invaded the surrounding skeletal muscles. The lesion was positive for Vimentin, CD99, CK and Bcl-2 in immunohistochemistry. The diagnosis of monophasic synovial sarcoma was made, and radical surgical excision was performed. Due to the paucity of synovial sarcoma in the oral region, the information about appropriate treatment for this sarcoma is limited. The knowledge about this rare entity and microscopic characteristics are important and help to have a proper diagnosis and improved treatment plan.

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Solitary fibrous tumor of the oral floor confirmed by the <i>NAB2</i>-<i>STAT6</i> fusion gene: a case report

FUJIMURA,

SUKEGAWA,

HIROSE

et al. 2024

Jpn. J. Oral. Maxillofac. Surg.

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Calcifying synovial sarcoma of the tongue with SS18 rearrangement: a rare variant in a rare location

Cited by 3 publications

References 33 publications

Synovial sarcoma of the head and neck: A review of reported cases on the clinical characteristics and treatment methods

Synovial sarcoma of the head and neck: A review of reported cases on the clinical characteristics and treatment methods

Primary synovial sarcoma of mandibular gingiva: An exceedingly rare case report

Solitary fibrous tumor of the oral floor confirmed by the <i>NAB2</i>-<i>STAT6</i> fusion gene: a case report

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