Calcium and bicarbonate ions mediate the inhibition of mast cell histamine release by Avène spa water

Abstract

Avène spa water (ASW) inhibits the histamine release induced in mast cells by substance P; the inhibition is reversed by EDTA and by EGTA. Calcium and magnesium ions, the major cations present in ASW, were experimented in simple saline solutions in the presence of various counter-ions. Only calcium salts inhibited the peptidergic stimulation, with different potencies ruled by the nature of the counter-anion (HCO3- > Cl- > SO4(2)). On a Ca2+ concentration basis, ASW was, however, more inhibitory, suggesting that other compounds present in ASW potentiate the effect of calcium.

Impact of Avène hydrotherapy on the quality of life of atopic and psoriatic patients

“…Indeed, in vitro experiments showed that Avène TSW treatment significantly reduced the percentage and area of dilated vessels stimulated by VIP. 26 Moreover, Avène TSW treatment inhibited basophil degranulation and histamine release from mast cells stimulated by substance P. 27,28 In addition to the properties of Avène TSW, the different physiotherapy programmes (showers, baths, massages, etc.) associated with hydrotherapy can be important factors in the overall effect.…”

Effect of São Pedro do Sul thermal water on skin irritation

“…This activity may be in part responsible for its anti‐inflammatory properties. It was found later, that calcium and bicarbonate ions mediate the inhibition of mast cell histamine release by this water [23]. Other studies demonstrated that Avène spa water has also an inhibitory effect on vasoactive intestinal peptide‐induced inflammation in skin that can also explain its properties.…”

Acceleration of keratinocyte differentiation by transient receptor potential vanilloid (TRPV6) channel activation

“…Some effects of Avène TSW on immune cells have already been shown as it 1 contributed equally to this work reduces basophile degranulation, 15 and histamine and prostaglandin D2 release from mast cells. 16,17 Avène TSW also acts on Th1 and Th2 cytokines production, 18 which is related to its anti-allergic and anti-inflammatory properties.…”