Calcium carbonate vaterite particles for drug delivery: Advances and challenges

Trushina, Daria B.; Bоrodinа, Tatyana N.; Belyakov, S. A.; Antipina, Maria N.

doi:10.1016/j.mtadv.2022.100214

Cited by 66 publications

(53 citation statements)

References 95 publications

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“…The loading percentages of the different CD/MOFs for CA were determined to be 20.25%, 28.42%, 27.17%, and 29.9%, which were significantly higher than that of pure MOF (18.02%). The loading capacities may be closely related to their porosities and surface area ( Trushina et al, 2022 ). As shown in Table S1 , the BET surface area of CD/MOF-0.5 was approximately 9.4 times broader than that of MOF.…”

Section: Resultsmentioning

confidence: 99%

Fabrication of γ-cyclodextrin-Based metal-organic frameworks as a carrier of cinnamaldehyde and its application in fresh-cut cantaloupes

Che

Chen²,

Song³

et al. 2022

Current Research in Food Science

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Section: Resultsmentioning

confidence: 99%

Fabrication of γ-cyclodextrin-Based metal-organic frameworks as a carrier of cinnamaldehyde and its application in fresh-cut cantaloupes

Che

Chen²,

Song³

et al. 2022

Current Research in Food Science

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“…The calcium carbonate particles can be employed as vehicles for carrying nanoparticles or various drugs due to their biocompatibility (Trushina et al, 2023). In a study conducted by Than et al (2012), modified eggshell powder as a pharmaceutical excipient in tablet and acetaminophen as a model drug were investigated.…”

Section: Nanoparticle's Carrier and Drug Deliverymentioning

confidence: 99%

Biogenic calcium carbonate derived from waste shells for advanced material applications: A review

Azarian

Sutapun

2022

Front. Mater.

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Biogenic calcium carbonate derived from waste shells has received significant attention in the last 2 decades as a replacement for limestone due to its contribution to reducing environmental impact by turning wastes into value-added biomaterial and moving global society toward net-zero waste. Recently, several review papers have been published regarding applying biogenic derived calcium carbonate in engineering, biomedical, electrochemical, and environmental technologies. This review stands apart from other reviews on this topic in terms of focusing and reviewing the published papers used and reported indirect methods only to obtain calcium carbonate from biogenic waste shells and not by direct methods. The direct or untreated methods include simple grinding, ball milling, or mortar and pestle techniques. In contrast, the indirect methods covered in this review paper consist of precipitation and different chemical treatment techniques. Therefore, this review paper aims to comprehensively summarize the usage of calcium carbonate derived from eggshells and seashells by indirect methods and glance at its recent development for advanced material applications including water treatment, bio-filler, and reinforcement in polymer composites, energy application, pharmaceutical, biomedical, and drug delivery applications.

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“…Calcite has numerous industrial applications such as filler in paper, plastics, rubber, paints and foodstuffs, due to its high stability and mechanical strength [ 19 , 20 ]. Aragonite has been proposed as a scaffold for bone repair and tissue engineering and other biomedical applications [ 21 ] whereas vaterite, due to both its porosity and surface area, has good properties for application in drug delivery [ 22 ]. In fact, the porous morphology and developed internal structure allow it to host both macromolecules and low molecular weight compounds which can be loaded by co-precipitation during vaterite formation or by adsorption [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

A New Challenge for the Old Excipient Calcium Carbonate: To Improve the Dissolution Rate of Poorly Soluble Drugs

Ambrogi

2023

Pharmaceutics

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Calcium carbonate is an excipient traditionally used in solid dosage forms with several functions such as a diluent, a quick dissolution agent, a buffer and an opacifier. Recently, many other challenges have arisen for calcium carbonate and, among them, the possibility of using it as an excipient for improving the dissolution rate of poorly soluble drugs. As a consequence of their poor solubility in biological fluids, many active ingredients suffer from low and erratic bioavailability when administered by the oral route and thus, many formulation strategies and excipients have been proposed to overcome this problem. Among them, calcium carbonate has been proposed as an excipient for improving dissolution rates. Calcium carbonate has many interesting characteristics, in fact it dissolves quickly in gastric fluid, is inexpensive and is safe. It exists in different polymorphic forms and in porous morphology and recently a porous functionalized calcium carbonate has been proposed as a new excipient. This review is the first overview on the use of calcium carbonate as an excipient for improving drug dissolution rates. The drug loading procedure, the physical characterization of the drug/CaCO3 samples and their dissolution profiles will be described. Moreover, the possible mechanisms of dissolution improvement, such as the presence of the drug in amorphous or polymorphic forms, in small crystals, and the effects of CaCO3 dissolution in acidic medium will be discussed. Different polymorphic forms of calcium carbonate and the presence of porosity and functionalization will be analyzed as well and their effects on dissolution rates will be discussed.

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Calcium carbonate vaterite particles for drug delivery: Advances and challenges

Cited by 66 publications

References 95 publications

Fabrication of γ-cyclodextrin-Based metal-organic frameworks as a carrier of cinnamaldehyde and its application in fresh-cut cantaloupes

Fabrication of γ-cyclodextrin-Based metal-organic frameworks as a carrier of cinnamaldehyde and its application in fresh-cut cantaloupes

Biogenic calcium carbonate derived from waste shells for advanced material applications: A review

A New Challenge for the Old Excipient Calcium Carbonate: To Improve the Dissolution Rate of Poorly Soluble Drugs

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