Calcium channels blocked activity: Providing the basis for medicinal use of &lt;i&gt;Abies pindrow&lt;/i&gt; in diarrhea and bronchitis

Mushtaq, Sohaib; Chaudhry, Mueen Ahmad; Rahman, Hafiz Muhammad Abdul

doi:10.3329/bjp.v10i2.22246

Cited by 10 publications

(6 citation statements)

References 11 publications

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“…Screening was performed by using isolated tissue preparations as they are rationally used in such investigations to authenticate the underlying mechanism(s) of pharmacological effects, without any intrinsic (neural or hormonal) involvement (Mushtaq et al. 2015 ).…”

Section: Discussionmentioning

confidence: 99%

A mechanistic evaluation of the traditional uses of Nepeta ruderalis in gastrointestinal and airway disorders

Mahmood

Chaudhry

Masood

et al. 2017

Pharmaceutical Biology

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Context:Nepeta ruderalis Buch.-Ham. (Lamiaceae), locally known as Badranj Boya, is an aromatic herb used traditionally as an antispasmodic, antidiarrhoeal, and anti-asthamatic remedy.Objective: Aqueous methanolic extract of N. ruderalis was studied to investigate its traditional uses.Materials and methods: Study was conducted from September 2015 to February 2016. In vitro spasmolytic and broncho-relaxant activity of crude extract of N. ruderalis (whole plant) was evaluated at 0.01–10 mg/mL final bath concentration in isolated rabbit jejunum and tracheal tissues, using PowerLab data acquisition system (Transonic Systems Inc., Ithaca, NY). In vivo antidiarrhoeal activity was evaluated in castor oil-induced diarrhoeal mice at the dose of 300 and 500 mg of crude extract orally.Results: Crude extract of N. ruderalis completely relaxed spontaneously contracting, high K+ (80 mM) and carbachol (1 μM) induced contracted jejunum with an EC50 value of 5.85 (5.45–6.27), 4.0 (3.80–4.23) and 2.86 (2.48–3.29), similar to verapamil. Nr.Cr relaxed high K+ and carbachol induced contractions, at 5 and 10 mg/mL with an EC50 value of 2.37 (2.11–2.67) and 3.26 (2.9–3.67), respectively, and also displaced calcium concentration–response curves toward right at 0.1 and 0.3 mg/mL. Nr.Cr exhibited antidiarrhoeal protection at a dose of 300 and 500 mg/kg, similar to verapamil, whereas no acute toxicity signs were seen up to 5 g/kg in healthy mice.Discussion and conclusion: Results suggest the presence of spasmolytic and broncho-relaxant effects in the crude extract of N. ruderalis, possibly mediated through calcium channel-blocking activity, providing the pharmacological basis for its traditional uses in gastrointestinal and airway disorders.

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Section: Discussionmentioning

confidence: 99%

A mechanistic evaluation of the traditional uses of Nepeta ruderalis in gastrointestinal and airway disorders

Mahmood

Chaudhry

Masood

et al. 2017

Pharmaceutical Biology

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“…High postassium, concentration is known to induce contractions of smooth muscles by opening of L-type calcium channels resulting in influx of extracellular calcium. The results indicate that A. pindrow can be used in treatment of diarrhoea and bronchitis due to its calcium channel blocking ability [44].…”

Section: Calcium Channel Blockagementioning

confidence: 91%

Ethnobotanical and Pharmacological Importance of Western Himalayan Fir Abies pindrow (Royle ex D. Don) Royle: A Review

Sinha¹

2019

JPRI

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Aims: Abies pindrow (Royle ex D. Don) Royle., colloquially known as the Western Himalayan fir, is a conifer that grows along the Himalayan mountains from Afghanistan to Nepal. The plant is extensively used by locals for the treatments of various ailments. Thus based on the available reports about its importance in traditional system of medicine, an attempt has been made to review this species in context of its medicinal and pharmaceutical importance. Study Design: The review article has been designed based on literature survey. The article is grossly divided into four broad phases consisting of compiled information of Abies pindrow: (1) Ethnobotanical information (2) Chemical Constituents (3) Pharmacological activities (4) Discussion mainly highlighting the mode of action of the bioactive compounds in relation to its pharmacological activity. Methodology: Extensive literature search have been performed in the web using PubMed, PubMed Central, google scholar as search platform. Efforts have also been taken to compile information from research papers and review articles not more than 10 years old. Information from old literatures were preferably avoided unless found to be very relevant to the subject. Results: The literature survey revealed that the plant has been used to treat cough and cold, diabetes, cataract and bladder diseases. The plant is also considered to be carminative, astringent, antispasmodic, diuretic, tonic and anti-inflammatory. The plant is also rich in terpenes and terpene alcohols. Testing for antidiabetic, neuroprotective, anticataract and antixiolytic activities have been promising and the bioactive constituents and efforts are made to interpret the possible mechanism of action of bioactive compounds in bringing about the pharmacological activities. Conclusion: It is concluded that the plant can be explored and bioprospected for an affordable source of drug and nutraceutical for better management of health related issues of people of Indian subcontinent.

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“…All isolated tissues of guinea pig ileum, rabbit jejunum, and trachea were prepared by following Mushtaq et al . [ 10 ] with minor modifications.…”

Section: Methodsmentioning

confidence: 99%

A pharmacological evidence for the presence of antihistaminic and anticholinergic activities in Equisetum debile Roxb

et al. 2017

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Calcium channels blocked activity: Providing the basis for medicinal use of <i>Abies pindrow</i> in diarrhea and bronchitis

Cited by 10 publications

References 11 publications

A mechanistic evaluation of the traditional uses of Nepeta ruderalis in gastrointestinal and airway disorders

A mechanistic evaluation of the traditional uses of Nepeta ruderalis in gastrointestinal and airway disorders

Ethnobotanical and Pharmacological Importance of Western Himalayan Fir Abies pindrow (Royle ex D. Don) Royle: A Review

A pharmacological evidence for the presence of antihistaminic and anticholinergic activities in Equisetum debile Roxb

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