Calcium Chloride Infusions are Not Associated with Improved Outcomes in Neonates Undergoing Cardiac Operations

Murray, Laura E.; Burchett, Holly; Chowdhury, Shahryar M; Haney, Ashley; Hassid, Marc; Strelow, Jacob; Graham, Eric M.; Kavarana, Minoo N.; Buckley, Jason R.

doi:10.1007/s00246-021-02730-x

Cited by 2 publications

(1 citation statement)

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“…Further studies are required to determine if calcium chloride and acetylcholine play a role in these processes ( Bayer et al, 2019 ). In addition to atria, calcium chloride and acetylcholine can act on the ventricular muscle, particularly calcium chloride ( Murray et al, 2022 ). The transient atrioventricular block after administration that lasts <1 min is associated with an atrioventricular conduction disturbance caused by acetylcholine that disappears naturally after acetylcholine is hemodiluted and metabolized.…”

Section: Discussionmentioning

confidence: 99%

Inhibitory effect of aloperine on transient outward potassium currents in rat cardiac myocytes

Dong,

2024

Front. Pharmacol.

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Objective:Aloperine (ALO) is an effective quinolizidine alkaloid. Previous research has demonstrated its antiarrhythmic effect by inhibiting voltage-gated sodium currents in rat ventricular myocytes. This study explored its effect on transient outward potassium currents (Ito) in rat atrial myocytes to identify potential targets in the context of ion channel currents.Methods:The Ito characteristics in rat atrial myocytes were recorded using a whole-cell patch-clamp technique. Molecular docking was performed to validate ligand-protein binding interactions.Results:ALO at concentrations of 3 and 10 μM significantly reduced Ito current densities. Gating kinetics analysis revealed ALO’s ability to slow Ito activation, hasten inactivation, and prolong transition from inactive to resting state. Molecular docking revealed that ALO could stably bind to KCND2.Conclusion:ALO may inhibit Ito by slowing the activation process, accelerating inactivation, and delaying the recovery time after inactivation, potentially preventing acetylcholine-induced AF.

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Section: Discussionmentioning

confidence: 99%