1998
DOI: 10.1006/bbrc.1998.8865
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Calcium-Dependent Nitric Oxide Synthase Activity in Rat Thymocytes

Abstract: can be triggered to produce NO (3-9), or that lymphocytes (15). Recent studies, suggest that depending on the concentration of NO, it may be either toxic or protective for signalling in thymocyte development (16)(17)(18)(19)(20). In mammalian cells, nitric oxide (NO) and citrulline Previous studies provided evidence for the presence are stoichiometrically generated from L-arginine (Lof the constitutive endothelial isoform of NO synthase Arg) in an enzymatic reaction catalysed by the nitric in T lymphocytes fr… Show more

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Cited by 10 publications
(1 citation statement)
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“…thymocytes can express constitutive NOS as well as iNOS, and produce low levels of Ca 2 + -induced NO, even in the presence of iNOS-inducing stimuli such as LPS and proinflammatory cytokines (19,28,185). It is yet to be seen whether the antiapoptotic actions of caspase S-nitrosylation generated by NO from constitutive NOS might also play an important role in modulating apoptosis during thymocyte maturation.…”
mentioning
confidence: 99%
“…thymocytes can express constitutive NOS as well as iNOS, and produce low levels of Ca 2 + -induced NO, even in the presence of iNOS-inducing stimuli such as LPS and proinflammatory cytokines (19,28,185). It is yet to be seen whether the antiapoptotic actions of caspase S-nitrosylation generated by NO from constitutive NOS might also play an important role in modulating apoptosis during thymocyte maturation.…”
mentioning
confidence: 99%