Calcium involvement in mediating the action of octopamine and hypertrehalosemic peptides on insect haemocytes

Jahagirdar, A.P.; Milton, G.; Viswanatha, T.; Downer, Roger

doi:10.1016/0014-5793(87)81195-x

Cited by 32 publications

(13 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…He proposed 3 subtypes and organized them into 2 major classes. OCT-1 receptors coupled to increases in intracellular calcium fluxes, a similar physiological response displayed by other insects (Jahagirdar, 1987). OCT-2 receptors were of two pharmacologically distinguishable subtypes, 2A and 2B, but both coupled to increases in cAMP (Evans, 1981;Evans, 1984;Evans & Robb, 1993).…”

Section: Invertebrate Trace Amine-activated Receptorsmentioning

confidence: 65%

Trace amine-associated receptor 1—Family archetype or iconoclast?

Grandy

2007

Pharmacology & Therapeutics

178

211

View full text Add to dashboard Cite

Interest has recently been rekindled in receptors that are activated by low molecular weight, noncatecholic, biogenic amines that are typically found as trace constituents of various vertebrate and invertebrate tissues and fluids. The timing of this resurgent focus on receptors activated by the 'trace amines' (TAs) β-phenylethylamine (PEA), tyramine (TYR), octopamine (OCT), synephrine (SYN), and tryptamine (TRYP) is the direct result of two publications that appeared in 2001 describing the cloning of a novel G protein-coupled receptor (GPCR) referred to by their discoverers as TA1 (Borowsky et al., 2001) and TAR1 (Bunzow et al., 2001). When heterologously expressed in Xenopus laevis oocytes and various eukaryotic cell lines recombinant rodent and human TA receptors dosedependently couple to the stimulation of cAMP production. Structure-activity profiling based on this functional response has revealed that in addition to the TAs, other biologically active compounds containing a 2 carbon aliphatic side chain linking an amino group to at least one benzene ring are potent and efficacious TA receptor agonists with amphetamine, methamphetamine, 3-iodothyronamine, thyronamine, and dopamine among the most notable. Almost 100 years after the search for TA receptors began numerous TA1/TAR1-related sequences, now called Trace AmineAssociated Receptors (TAARs), have been identified in the genome of every species of vertebrate examined to date. Consequently, even though heterologously expressed TAAR1 fits the pharmacological criteria established for a bona fide TA receptor a major challenge for those working in the field is to discern the in vivo pharmacology and physiology of each purported member of this extended family of GPCRs. Only then will it be possible to establish whether TAAR1 is the family archetype or an iconoclast.

show abstract

Section: Invertebrate Trace Amine-activated Receptorsmentioning

confidence: 65%

Trace amine-associated receptor 1—Family archetype or iconoclast?

Grandy

2007

Pharmacology & Therapeutics

178

211

View full text Add to dashboard Cite

show abstract

“…Some insect octopamine receptors are thought to be coupled to the IP 3 system that activates the release of Ca ?? from internal stores (Jahagirdar et al 1987;Baines and Downer 1994). U-73122 is an inhibitor of phospholipase C, the enzyme that catalyzes the synthesis of IP 3 from phosphotidylinositol 4,5-bisphosphate.…”

Section: Discussionmentioning

confidence: 99%

IP3-mediated octopamine-induced synaptic enhancement of crayfish LG neurons

Araki

Nagayama

2012

J Comp Physiol A

View full text Add to dashboard Cite

The biogenic amines, octopamine and serotonin, modulate the synaptic activity of the lateral giant interneuron (LG) circuitry of the crayfish escape behavior. Bath application of both octopamine and serotonin enhances the synaptic responses of LG to sensory stimulation. We have shown previously (Araki et al. J Neurophysiol 94:2644-2652, 2005) that a serotonin-induced enhancement of the LG response was mediated by an increase in cAMP levels following activation of adenylate cyclase; however, octopamine acts independently. Here, we clarify how octopamine enhances the LG response during sensory stimulation using physiological and pharmacological analyses. When phospholipase C inhibitor U-73122 was directly injected into the LG before biogenic amine application, it abolished the enhancing effect of octopamine on direct sensory input to the LG, but did not block indirect input via sensory interneurons or the effect of serotonin. Direct injection of IP(3), and its analogue adenophostin A, into the LG increased the synaptic response of the LG to sensory stimulation. Thus, IP(3) mediates octopamine-induced synaptic enhancement of the LG, but serotonin acts independently. These results indicate that both octopamine and serotonin enhance the synaptic responses of the LG to sensory stimulation, but that they activate two different signaling cascades in the LG.

show abstract

“…In cockroach fat body cells hypertrehalosemic hormone HT I ( = NHD) activates phosphorylase kinase only if external Ca 2+ is present (Orr et al 1985). In blowfly blood cells the same hormone elevates the intracellular [Ca 2+] (Jahagirdar et al 1987). Another adipokinetic hormone, AKH I, stimulates glycogenolysis in the locust.…”

Section: Role Of Calcium For the Action Of Nhd On Non-neuronal Cellsmentioning

confidence: 99%

“…Subsequently it was shown to be an octapeptide of the amino acid sequence pGlu-Val-Asn-PheSer-Pro-Asn-TrpNH2 (Scarborough et al 1984;Baumann and Penzlin 1984;Witten et al 1984). Neurohormone D is also termed myotropin I , periplanetin CC I (Scarborough et al 1984), hypertrehalosemic hormone HT I (Orr et al 1985;Jahagirdar et al 1987) and Pea-CAH-I (Raina and G/ide 1988).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Neurohormone D induces ionic current changes in cockroach central neurones

1994

View full text Add to dashboard Cite

The octapeptide neurohormone D (NHD), a member of the family of adipokinetic hormones (AKH-peptides), increases the frequency of spontaneous activity in dorsal unpaired median (DUM) neurones isolated from the terminal ganglion of the cockroach Periplaneta americana. The increase in spike frequency is accompanied by changes in the shape and the amplitude of the single action potentials, e.g. a more pronounced afterhyperpolarization. Effects of NHD on membrane currents were investigated in these DUM cells with whole-cell voltage-clamp measurements. A voltage-independent Ca2+ current flowing at the resting potential (ICa,R) was found. NHD, at nanomolar concentrations, enhanced this ICa,R in a concentration-dependent manner. 0.1 mM Cd2+ markedly reduced ICa,R and in this case ICa,R was hardly potentiated by NHD. In the presence of NHD a fast activating Ca(2+)-dependent K+ current sensitive to charybdotoxin and to low concentrations of tetraethylammonium was augmented. The enhanced afterhyperpolarization of action potentials can be accounted for by the increase in the Ca(2+)-dependent K+ current. The changes of the membrane currents induced by NHD are discussed with respect to further effects on the spike pattern and in relation to the previously described mode of action of AKH-peptides in other preparations.

show abstract

Calcium involvement in mediating the action of octopamine and hypertrehalosemic peptides on insect haemocytes

Cited by 32 publications

References 18 publications

Trace amine-associated receptor 1—Family archetype or iconoclast?

Trace amine-associated receptor 1—Family archetype or iconoclast?

IP3-mediated octopamine-induced synaptic enhancement of crayfish LG neurons

Neurohormone D induces ionic current changes in cockroach central neurones

Contact Info

Product

Resources

About