Calcium isotope composition in serum and urine for the assessment of bone mineral balance (BMB) – The Osteolabs post-market follow-up study

Eisenhauer, A.; Hastuti, A.; Heuser, A.; Kolevica, A.; Brandt, B.; Shroff, R.; Oehme, J.; Müller, M.

doi:10.1016/j.bone.2024.117210

Bone

2024

DOI: 10.1016/j.bone.2024.117210

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Calcium isotope composition in serum and urine for the assessment of bone mineral balance (BMB) – The Osteolabs post-market follow-up study

A. Eisenhauer,

A. Hastuti,

A. Heuser

et al.

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Magnitude and timescales of Ca isotope variability in human urine: implications for bone mass balance monitoring

Tissot,

Cleveland,

Grigoryan

et al. 2024

Metallomics

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Calcium (Ca) isotopes in blood/urine are emerging biomarkers of bone mineral balance (BMB) in the human body. While multiple studies have investigated Ca isotopes in patients suffering from diseases affecting BMB, comparatively little effort has been devoted to understanding the homeostasis of Ca isotopes in healthy individuals. Here, we report on a longitudinal study of the urine Ca isotope composition (δ44/42CaUrine) from 22 healthy participants (age 19 to 60) over timescales ranging from days to months. Data from a single participant collected over a 30-day period show that morning urine is an excellent proxy for 24 hr pooled urine fractions. Data from all participants reveal large inter-individual variability in δ44/42CaUrine (up to 2.2 ‰), which is partly due to anthropometric differences, as shown by a correlation between the participants’ body mass index (BMI) and δ44/42CaUrine values. In contrast, intra-individual data reveal encouraging stability (within ∼ ±0.2-0.3 ‰) over timescales > 160 days, indicating that self-referencing approaches for BMB monitoring hold greater promise than cross sectional ones. Our data confirm that intra-individual δ44/42CaUrine variations are mainly a function of Ca reabsorption in the kidney, but also reveal the impact of other (and at times equally important) drivers, such as diet, alcohol consumption, physical exercise, or fasting. We also find that a magnetic resonance imaging contrast agent (gadolinium) can lead to artifacts during Ca isotope analysis. Based on our results, a series of practical considerations for the use of Ca isotopes in urine as tracers of BMB is presented.

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Magnitude and timescales of Ca isotope variability in human urine: implications for bone mass balance monitoring

Tissot,

Cleveland,

Grigoryan

et al. 2024

Metallomics

View full text Add to dashboard Cite

show abstract

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Calcium isotope composition in serum and urine for the assessment of bone mineral balance (BMB) – The Osteolabs post-market follow-up study

Cited by 1 publication

References 43 publications

Magnitude and timescales of Ca isotope variability in human urine: implications for bone mass balance monitoring

Magnitude and timescales of Ca isotope variability in human urine: implications for bone mass balance monitoring

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