Calcium‐Modified Silk as a Biocompatible and Strong Adhesive for Epidermal Electronics

Seo, Jiwon; Kim, Hyojung; Kim, Kyu-Han; Choi, Siyoung Q.; Lee, Hyunjoo Jenny

doi:10.1002/adfm.201800802

Cited by 162 publications

(157 citation statements)

References 72 publications

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“…[232][233][234][235] The rapid advancement of exible electronics and the recent use of natural biomaterials, such as sodium alginate, silk, chitin, cellulose, etc., as the active components and substrates of exible sensing systems has accelerated the development of more user-friendly wearable devices. [236][237][238][239][240][241][242][243] These elastic, biocompatible substrates prevent direct contact between the user and integrated sensors, evading the possibility of skin irritation. [244][245][246] However, interactions between the human body and a single substance is difficult to predict due to complex biological reactions.…”

Section: Biocompatibilitymentioning

confidence: 99%

Flexible potentiometric pH sensors for wearable systems

2020

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Section: Biocompatibilitymentioning

confidence: 99%

Flexible potentiometric pH sensors for wearable systems

2020

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“…The lap shear test was performed after the HBPA was adhered to different substrates underwater and www.advmat.de www.advancedsciencenews.com time in water is extended to 72 h, the adhesion strength drops significantly, because of the gradual hydrolysis of ester bonds in the HBPA molecular chains ( Figure 3D-G). [14,[30][31][32][33][34][35][36] Figure 4A shows that the PE sheets glued with the HBPA (adhesion area: 2.5 cm × 2.5 cm) soaked in water for 36 h can still lift a bucket of water weighing 5 kg (Movie S2, Supporting Information). Until now, almost no literature has reported that adhesives can exhibit such high adhesion strength to PTFE and PE even in the dry state ( Figure 3H).…”

Section: Doi: 101002/adma201905761mentioning

confidence: 99%

Water‐Triggered Hyperbranched Polymer Universal Adhesives: From Strong Underwater Adhesion to Rapid Sealing Hemostasis

et al. 2019

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is greatly decreased or even eliminated. For instance, the widely used cyanoacrylate adhesives exhibit strong adhesion in air, but when applied in water environment, they are hardened quickly to form a layer of stiff plastics, eventually resulting in the loss of adhesion. [9] The commercially available epoxy resins [10] and polyurethanes [11] are reported to demonstrate strong underwater adhesion, but long time of curing is usually required. Recently, host-guest chemistry strategy was reportedly employed to prepare underwater adhesives; however, the substrate surface needs to be modified in advance. [5,12] In addition, electrostatic and hydrophobic interactions were also proved to contribute to enhanced underwater adhesion, but the adhesion strength was relatively poor. [13,14] In nature, many organisms, such as mussels, barnacles, and castle worms, have evolved an unparalleled mechanism to perfectly tackle the underwater adhesion problem. [15][16][17] The finding of universality of catechol chemistry for wet adhesion has provided a valuable biomimetic source to develop diverse adhesives for use in aqueous environments. However, several problems, such as the complexity of administration, release of harmful organic solvents, [18,19] long-term curing, [2] need for oxidant addition, [20,21] and low adhesion strength, [18,22] may hamper the actual applications of these bioinspired adhesives. Although numerous dopamine-based adhesives have been reported and shown to bond various material surfaces, strong adhesion in water and particularly blood environment, remains nonexistent so far.Increasing studies on bioadhesives secreted by molluscs and insects have suggested that liquid coacervation plays a critical role in achieving underwater adhesion. [13] In this process, phase separation and concurrently increased hydrophobicity induced by coacervation can dispel the hydrated water on the interface, leading to much enhanced interaction of adhesive groups with the adherent and thus stable underwater adhesion. Up to date, several complex coacervate adhesives with linear structure have been reported, but the occurrence of those coacervations in water needs external triggers, such as temperature, [13] pH, [20,23] and iron strength. [24] Compared to linear counterparts, hyperbranched polymer (HBP) has a unique highly branched Despite recent advance in bioinspired adhesives, achieving strong adhesion and sealing hemostasis in aqueous and blood environments is challenging. A hyperbranched polymer (HBP) with a hydrophobic backbone and hydrophilic adhesive catechol side branches is designed and synthesized based on Michael addition reaction of multi-vinyl monomers with dopamine.It is demonstrated that upon contacting water, the hydrophobic chains selfaggregate to form coacervates quickly, displacing water molecules on the adherent surface to trigger increased exposure of catechol groups and thus rapidly strong adhesion to diverse materials from low surface energy to high energy in various environments, such as deionized water, sea ...

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“…We have engineered Ca-modified RS which is able to absorb water and form adhesions on wet tissue. The Ca-modified RS is a material with a high water absorption [14]. The material applies compressive strains at the interface with the substrate, which results in a sealant effect on anastomosed tissues.…”

Section: Introductionmentioning

confidence: 99%

Plasticised Regenerated Silk/Gold Nanorods Hybrids as Sealant and Bio-Piezoelectric Materials

et al. 2020

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Manual and mechanical suturing are currently the gold standard for bowel anastomosis. If tissue approximation fails, anastomotic leaks occur. Anastomotic leaks may have catastrophic consequences. The development of a fully absorbable, biocompatible sealant material based on a bio-ink silk fibroin can reduce the chance of anastomotic leaks. We have produced a Ca-modified plasticised regenerated silk (RS) with gold nanorods sealant. This sealant was applied to anastomosed porcine intestine. Water absorption from wet tissue substrate applied compressive strains on hybrid RS films. This compression results in a sealant effect on anastomosis. The increased toughness of the hybrid plasticised RS resulted in the designing of a bio-film with superior elongation at break (i.e., ≈200%) and bursting pressure. We have also reported structure-dependent piezoelectricity of the RS film that shows a piezoelectric effect out of the plane. We hope that in the future, bowel anastomosis can be simplified by providing a multifunctional bio-film that makes feasible the mechanical tissue joint without the need for specific tools and could be used in piezoelectric sealant heads.

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Calcium‐Modified Silk as a Biocompatible and Strong Adhesive for Epidermal Electronics

Cited by 162 publications

References 72 publications

Flexible potentiometric pH sensors for wearable systems

Flexible potentiometric pH sensors for wearable systems

Water‐Triggered Hyperbranched Polymer Universal Adhesives: From Strong Underwater Adhesion to Rapid Sealing Hemostasis

Plasticised Regenerated Silk/Gold Nanorods Hybrids as Sealant and Bio-Piezoelectric Materials

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