Calcium Oxalate Crystal Adherence to Hyaluronan-, Osteopontin-, and CD44-Expressing Injured/Regenerating Tubular Epithelial Cells in Rat Kidneys

Asselman, Marino; Verhulst, Anja; Broe, Marc E. De; Verkoelen, Carl F.

doi:10.1097/01.asn.0000099380.18995.f7

Cited by 186 publications

(168 citation statements)

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“…CD44 is expressed together with OPN and HA in injured/regenerating tubular epithelial cells by CaOx crystal adherence in rat kidneys. (35) On the other hand, CD44 is reported to be a phagocytic receptor that is able to trigger the ingestion of large particles by macrophages. (36,37) Mgp encodes matrix gla protein (MGP), which is a vitamin K-dependent and Ca-binding protein.…”

Section: Discussionmentioning

confidence: 99%

Renal macrophage migration and crystal phagocytosis via inflammatory-related gene expression during kidney stone formation and elimination in mice: Detection by association analysis of stone-related gene expression and microstructural observation

Okada

Yasui

Fujii

et al. 2010

Journal of Bone and Mineral Research

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Mice have a strong ability to eliminate renal calcium oxalate crystals, and our previous examination indicated a susceptibility in which monocyte-macrophage interaction could participate in the phenomenon. To clarify the macrophage-related factors playing roles in the prevention of crystal formation in mouse kidneys, morphologic and expression studies based on microarray pathway analysis were performed. Eight-week-old male C57BL/6N mice were administered 80 mg/kg of glyoxylate by daily intraabdominal injection for 15 days, and the kidneys were extracted every 3 days for DNA microarray analysis. Based on the raw data of microarray analysis, pathway analyses of inflammatory response demonstrated macrophage activation through the increased expression of chemokine (C-X-C) ligand 1, fibronectin 1, and major histocompatability (MHC) class II. Association analysis of related gene expression values by quantitative reverse transcription polymerase chain reaction (RT-PCR) indicated the high association of chemokine (C-C) ligand 2, CD44, colony-stimulating factor 1, fibronectin 1, matrix gla protein, secreted phosphoprotein 1, and transforming growth factor b1 (TGF-b1) with the amount of both renal crystals and F4/80, a macrophage marker. Immunohistochemically, interstitial macrophages increased during the experimental course, and CD44 and MHC class II were upregulated around crystal-formation sites. Ultrastructural observation of renal macrophages by transmission electron microscopy indicated interstitial macrophage migration with the phagocytosis of crystals. In conclusion, increased expression of inflammation-related genes of renal tubular cells induced by crystal formation and deposition could induce monocyte-macrophage migration and phagocytosis via the interaction of CD44 with osteopontin and fibronectin. Such crystalremoving ability of macrophages through phagocytosis and digestion might become a new target for the prevention of stone formation. ß

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Section: Discussionmentioning

confidence: 99%

Renal macrophage migration and crystal phagocytosis via inflammatory-related gene expression during kidney stone formation and elimination in mice: Detection by association analysis of stone-related gene expression and microstructural observation

Okada

Yasui

Fujii

et al. 2010

Journal of Bone and Mineral Research

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“…CARPs 1-3 trap and direct Ca +2 to calcification sites with specific roles assigned to each protein. CARPs 1 and 4 form crystal binding substrates that lead to CaCO 3 nucleation, as evidenced by their presence in the EMZs, similar to osteopontin, which nucleates human kidney stones (54). CARP 2's role is in extension, potentially at night, contributing to the more soluble FGS.…”

Section: Discussionmentioning

confidence: 99%

Immunolocalization of skeletal matrix proteins in tissue and mineral of the coralStylophora pistillata

Mass

Drake

Peters

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

104

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The precipitation and assembly of calcium carbonate skeletons by stony corals is a precisely controlled process regulated by the secretion of an ECM. Recently, it has been reported that the proteome of the skeletal organic matrix (SOM) contains a group of coral acid-rich proteins as well as an assemblage of adhesion and structural proteins, which together, create a framework for the precipitation of aragonite. To date, we are aware of no report that has investigated the localization of individual SOM proteins in the skeleton. In particular, no data are available on the ultrastructural mapping of these proteins in the calcification site or the skeleton. This information is crucial to assessing the role of these proteins in biomineralization. Immunological techniques represent a valuable approach to localize a single component within a calcified skeleton. By using immunogold labeling and immunohistochemical assays, here we show the spatial arrangement of key matrix proteins in tissue and skeleton of the common zooxanthellate coral, Stylophora pistillata. To our knowledge, our results reveal for the first time that, at the nanoscale, skeletal proteins are embedded within the aragonite crystals in a highly ordered arrangement consistent with a diel calcification pattern. In the tissue, these proteins are not restricted to the calcifying epithelium, suggesting that they also play other roles in the coral's metabolic pathways.actin | carbonic anhydrase | CARPs | cadherins C orals (phylum Cnidaria) belong to one of the oldest invertebrate phyla and are one of the earliest metazoans to possess an organized body structure (reviewed in ref.

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“…The oxalate → calcium oxalate conversion can also occur unintentionally in humans; a reaction that underpins the deleterious formation of calcium oxalate deposits (so-called "kidney stones") within the urinary system. Extensive research on the formation of kidney stones highlights that the oxalate → calcium oxalate transition is enhanced by the presence of crystal binding substances, including hyaluronan (hyaluronic acid, HA) and osteopontin (OPN) (Asselman et al, 2003;Lamontagne et al, 2011). HA is a linear polysaccharide whose numerous charges along its length result in a complex interaction with cations, particularly Ca +2 (Gabriel and Carr, 1989).…”

Section: Fig 5 (A)mentioning

confidence: 99%

A new conceptual model of coral biomineralisation: hypoxia as the physiological driver of skeletal extension

Wooldridge

2013

Biogeosciences

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That corals skeletons are built of aragonite crystals with taxonomy-linked ultrastructure has been well understood since the 19th century. Yet, the way by which corals control this crystallization process remains an unsolved question. Here, I outline a new conceptual model of coral biomineralisation that endeavours to relate known skeletal features with homeostatic functions beyond traditional growth (structural) determinants. In particular, I propose that the dominant physiological driver of skeletal extension is night-time hypoxia, which is exacerbated by the respiratory oxygen demands of the coral's algal symbionts (= zooxanthellae). The model thus provides a new narrative to explain the high growth rate of symbiotic corals, by equating skeletal deposition with the "work-rate" of the coral host needed to maintain a stable and beneficial symbiosis. In this way, coral skeletons are interpreted as a continuous (long-run) recording unit of the stability and functioning of the coral–algae endosymbiosis. After providing supportive evidence for the model across multiple scales of observation, I use coral core data from the Great Barrier Reef (Australia) to highlight the disturbed nature of the symbiosis in recent decades, but suggest that its onset is consistent with a trajectory that has been followed since at least the start of the 1900s. In concluding, I outline how the proposed capacity of cnidarians (which includes modern reef corals) to overcome the metabolic limitation of hypoxia via skeletogenesis also provides a new hypothesis to explain the sudden appearance in the fossil record of calcified skeletons at the Precambrian–Cambrian transition – and the ensuing rapid appearance of most major animal phyla

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Calcium Oxalate Crystal Adherence to Hyaluronan-, Osteopontin-, and CD44-Expressing Injured/Regenerating Tubular Epithelial Cells in Rat Kidneys

Cited by 186 publications

References 50 publications

Renal macrophage migration and crystal phagocytosis via inflammatory-related gene expression during kidney stone formation and elimination in mice: Detection by association analysis of stone-related gene expression and microstructural observation

Renal macrophage migration and crystal phagocytosis via inflammatory-related gene expression during kidney stone formation and elimination in mice: Detection by association analysis of stone-related gene expression and microstructural observation

Immunolocalization of skeletal matrix proteins in tissue and mineral of the coralStylophora pistillata

A new conceptual model of coral biomineralisation: hypoxia as the physiological driver of skeletal extension

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