Calcium Phosphate Biomaterials for 3D Bioprinting in Bone Tissue Engineering

Tolmacheva, Nelli; Bhattacharyya, Amitava; Noh, Insup

doi:10.3390/biomimetics9020095

Cited by 5 publications

(2 citation statements)

References 99 publications

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“…Well-known examples in the industrial world include burr-inspired Velcro, bird-inspired airplanes, and sharkskin-inspired Olympic swimsuits [ 100 ]. In the medical field, drug-delivering nanoparticles (NPs) mimic vesicles and liposomes [ 100 , 101 ]. Additionally, biomimetic engineering plays a promising role in tissue engineering, where scaffolds mimic tissue structures and/or cell–cell interactions.…”

Section: Biomimetic Engineering Of Biomaterialsmentioning

confidence: 99%

Natural Compounds and Biomimetic Engineering to Influence Fibroblast Behavior in Wound Healing

Berry,

Brenac,

Gonzalez

et al. 2024

IJMS

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Throughout history, natural products have played a significant role in wound healing. Fibroblasts, acting as primary cellular mediators in skin wound healing, exhibit behavioral responses to natural compounds that can enhance the wound healing process. Identifying bioactive natural compounds and understanding their impact on fibroblast behavior offers crucial translational opportunities in the realm of wound healing. Modern scientific techniques have enabled a detailed understanding of how naturally derived compounds modulate wound healing by influencing fibroblast behavior. Specific compounds known for their wound healing properties have been identified. Engineered biomimetic compounds replicating the natural wound microenvironment are designed to facilitate normal healing. Advanced delivery methods operating at micro- and nano-scales have been developed to effectively deliver these novel compounds through the stratum corneum. This review provides a comprehensive summary of the efficacy of natural compounds in influencing fibroblast behavior for promoting wound regeneration and repair. Additionally, it explores biomimetic engineering, where researchers draw inspiration from nature to create materials and devices mimicking physiological cues crucial for effective wound healing. The review concludes by describing novel delivery mechanisms aimed at enhancing the bioavailability of natural compounds. Innovative future strategies involve exploring fibroblast-influencing pathways, responsive biomaterials, smart dressings with real-time monitoring, and applications of stem cells. However, translating these findings to clinical settings faces challenges such as the limited validation of biomaterials in large animal models and logistical obstacles in industrial production. The integration of ancient remedies with modern approaches holds promise for achieving effective and scar-free wound healing.

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Section: Biomimetic Engineering Of Biomaterialsmentioning

confidence: 99%

Natural Compounds and Biomimetic Engineering to Influence Fibroblast Behavior in Wound Healing

Berry,

Brenac,

Gonzalez

et al. 2024

IJMS

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“…To finalize this section, one should note that due to the rapid development of additive manufacturing techniques, presumably, by means of the subsequent modifications, any type of CaPO 4 -containing biocomposite and hybrid formulation might be 3D printed [1147].…”

Section: Inks For 3d Printingmentioning

confidence: 99%

Calcium Orthophosphate (CaPO4) Containing Composites for Biomedical Applications: Formulations, Properties, and Applications

Dorozhkin

2024

J. Compos. Sci.

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The goal of this review is to present a wide range of hybrid formulations and composites containing calcium orthophosphates (abbreviated as CaPO4) that are suitable for use in biomedical applications and currently on the market. The bioactive, biocompatible, and osteoconductive properties of various CaPO4-based formulations make them valuable in the rapidly developing field of biomedical research, both in vitro and in vivo. Due to the brittleness of CaPO4, it is essential to combine the desired osteologic properties of ceramic CaPO4 with those of other compounds to create novel, multifunctional bone graft biomaterials. Consequently, this analysis offers a thorough overview of the hybrid formulations and CaPO4-based composites that are currently known. To do this, a comprehensive search of the literature on the subject was carried out in all significant databases to extract pertinent papers. There have been many formulations found with different material compositions, production methods, structural and bioactive features, and in vitro and in vivo properties. When these formulations contain additional biofunctional ingredients, such as drugs, proteins, enzymes, or antibacterial agents, they offer improved biomedical applications. Moreover, a lot of these formulations allow cell loading and promote the development of smart formulations based on CaPO4. This evaluation also discusses basic problems and scientific difficulties that call for more investigation and advancements. It also indicates perspectives for the future.

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Wet chemical synthesis of nanohydroxyapatite within poly(sodium sulfonated butylene fumarate‐co‐acrylic acid) as bone scaffold: effects of sulfonate and carboxylic acid groups

Mahmoudzadeh,

Shirali,

Taromi

2024

Polymer International

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This study investigates the synthesis, nucleation and modification of biodegradable poly(sodium sulfonated butylene fumarate‐co‐acrylic acid)/hydroxyapatite nanocomposite scaffolds for bone tissue engineering, with a focus on the effects of incorporating hydrophilic sulfonate and carboxylic acid groups. Poly(butylene fumarate) was sulfonated at varying degrees and used to form nanocomposites through in situ nucleation of nanohydroxyapatite (nHA) in a simulated body fluid solution. Critical parameters such as water absorption, swelling behavior, mechanical properties, nanoparticle dispersion and biocompatibility were evaluated. Water uptake ratios ranged from 2.72 to 6.88 g g−1, while compressive modulus values increased up to 25.9 times compared with the corresponding homopolymers, demonstrating improved mechanical stability. Despite the formation of over 80% nanoparticles, well‐distributed nHA, with sizes averaging 39 ± 13 nm, was achieved through the incorporation of sulfonated groups, preventing nanoparticle agglomeration within the scaffold matrix. Additionally, the scaffolds supported human dermal fibroblast adhesion and proliferation, with cell viability remaining high throughout the culture period. These results suggest that the developed nanocomposite scaffolds offer enhanced biocompatibility, mechanical strength and osteogenic potential, making them promising candidates for bone tissue regeneration applications. © 2024 Society of Chemical Industry.

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Calcium Phosphate Biomaterials for 3D Bioprinting in Bone Tissue Engineering

Cited by 5 publications

References 99 publications

Natural Compounds and Biomimetic Engineering to Influence Fibroblast Behavior in Wound Healing

Natural Compounds and Biomimetic Engineering to Influence Fibroblast Behavior in Wound Healing

Calcium Orthophosphate (CaPO4) Containing Composites for Biomedical Applications: Formulations, Properties, and Applications

Wet chemical synthesis of nanohydroxyapatite within poly(sodium sulfonated butylene fumarate‐co‐acrylic acid) as bone scaffold: effects of sulfonate and carboxylic acid groups

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