Calcium phosphate bone graft substitutes: Failures and hopes

Bohner, Marc; Galea, Laëtitia; Doebelin, Nicola

doi:10.1016/j.jeurceramsoc.2012.02.028

Cited by 227 publications

(173 citation statements)

References 106 publications

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“…IGF-I and IGF-II have essential roles in bone growth, development, remodeling and repair. TGF-β, initially purified from platelets, stimulates matrix protein synthesis, has dramatic effects on osteoblast and osteoclast activity (Bonewald et al, 1990). Blood platelets are also a rich source of platelet-derived growth factor (PDGF), a potent stimulant of mesenchymal cell proliferation and migration such as fibroblasts and vascular smooth muscle cells (Kilian et al, 2004).…”

Section: Regulatory Signalsmentioning

confidence: 99%

“…CP ceramics have a compositional resemblance to bone mineral, as such, the degradation of such biomaterials can elicit a biological response similar to the one generated during bone remodelling (Barrere et al, 2006). The calcium and phosphate ions released during degradation can induce bone cell activity (Zaidi et al, 1989;Kanatani et al, 1991) and may also be used as raw materials for new bone formation (Metsger et al, 1993;Bohner et al, 2012).…”

Section: Regulatory Signalsmentioning

confidence: 99%

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Cell-scaffold interactions in the bone tissue engineering triad

Murphy

O’Brien²,

Little³

et al. 2013

eCM

253

176

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Bone tissue engineering has emerged as one of the leading fields in tissue engineering and regenerative medicine. The success of bone tissue engineering relies on understanding the interplay between progenitor cells, regulatory signals, and the biomaterials/scaffolds used to deliver themotherwise known as the tissue engineering triad. This review will discuss the roles of these fundamental components with a specific focus on the interaction between cell behaviour and scaffold structural properties. In terms of scaffold architecture, recent work has shown that pore size can affect both cell attachment and cellular invasion. Moreover, different materials can exert different biomechanical forces, which can profoundly affect cellular differentiation and migration in a cell type specific manner. Understanding these interactions will be critical for enhancing the progress of bone tissue engineering towards clinical applications.

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Section: Regulatory Signalsmentioning

confidence: 99%

Section: Regulatory Signalsmentioning

confidence: 99%

Cell-scaffold interactions in the bone tissue engineering triad

Murphy

O’Brien²,

Little³

et al. 2013

eCM

253

176

View full text Add to dashboard Cite

show abstract

“…Moreover, biodegradable polymeric matrices have been investigated as temporary bone-grafts substitutes due to their integration with growing tissue during the healing process (Armentano et al, 2010). Although many materials have been used as synthetic bone-grafts, none of them has reached the three essential criteria for ideal bone replacement: mechanical properties, biodegradability, and osteoinductivity (Bonher et al, 2012). Thus, continuous research has being developed toward to more adequate bonegraft substitutes (Bonher et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…Although many materials have been used as synthetic bone-grafts, none of them has reached the three essential criteria for ideal bone replacement: mechanical properties, biodegradability, and osteoinductivity (Bonher et al, 2012). Thus, continuous research has being developed toward to more adequate bonegraft substitutes (Bonher et al, 2012). Herein, we proposed a composite material based on chitosan and calcium phosphate with adjustable mechanical properties for potential application as bone-graft substitute.…”

Section: Introductionmentioning

confidence: 99%

“…Sintered hydroxyapatite has been used in synthetic bone-graft substitutes due to its chemical similarity to bone mineral. However, the resorption rate of sintered hydroxyapatite is very low and may compromise biodegradation of the graft (Bonher et al, 2012). In order to prepare fast-resorbable bone-graft substitutes, hydroxyapatite has been replaced for more-soluble, biphasic CP, such as alpha and beta tri-calcium phosphate (Hu et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Morphological and mechanical characterization of chitosan-calcium phosphate composites for potential application as bone-graft substitutes

et al. 2015

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Introduction: Bone diseases, aging and traumas can cause bone loss and lead to bone defects. Treatment of bone defects is challenging, requiring chirurgical procedures. Bone grafts are widely used for bone replacement, but they are limited and expensive. Due to bone graft limitations, natural, semi-synthetic, synthetic and composite materials have been studied as potential bone-graft substitutes. Desirable characteristics of bone-graft substitutes are high osteoinductive and angiogenic potentials, biological safety, biodegradability, bone-like mechanical properties, and reasonable cost. Herein, we prepared and characterized potential bone-graft substitutes composed of calcium phosphate (CP) -a component of natural bone, and chitosan (CS) -a biocompatible biopolymer. Methods: CP-CS composites were synthetized, molded, dried and characterized. The effect of drying temperatures (38 and 60 °C) on the morphology, porosity and chemical composition of the composites was evaluated. As well, the effects of drying temperature and period of drying (3, 24, 48 and 72 hours) on the mechanical properties -compressive strength, modulus of elasticity and relative deformation-of the demolded samples were investigated. Results: Scanning electron microscopy and gas adsorption-desorption analyses of the CS-CP composites showed interconnected pores, indicating that the drying temperature played an important role on pores size and distribution. In addition, drying temperature have altered the color (brownish at 60 °C due to Maillard reaction) and the chemical composition of the samples, confirmed by FTIR. Conclusion: Particularly, prolonged period of drying have improved mechanical properties of the CS-CP composites dried at 38 °C, which can be designed according to the mechanical needs of the replaceable bone.

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Cements

Castaño¹,

Planell²

2014

Bio‐Ceramics With Clinical Applications

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Calcium phosphate bone graft substitutes: Failures and hopes

Cited by 227 publications

References 106 publications

Cell-scaffold interactions in the bone tissue engineering triad

Cell-scaffold interactions in the bone tissue engineering triad

Morphological and mechanical characterization of chitosan-calcium phosphate composites for potential application as bone-graft substitutes

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