Calcium Pyrophosphate and Basic Calcium Phosphate Crystal Arthritis: 2023 in Review

Latourte, Augustin; Ea, Hang-Korng; Richette, Pascal

doi:10.3390/gucdd2020010

Cited by 5 publications

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Features Associated With Different Inflammatory Phenotypes of Calcium Pyrophosphate Deposition Disease: A Study Using Data From the International American College of Rheumatology/EULAR Calcium Pyrophosphate Deposition Classification Criteria Cohort

Pascart,

Latourte,

Tedeschi

et al. 2024

Arthritis & Rheumatology

View full text Add to dashboard Cite

ObjectiveTo examine the disease, demographic, and imaging features associated with different inflammatory phenotypes of calcium pyrophosphate deposition (CPPD) disease i.e., recurrent acute CPP crystal arthritis, chronic CPP crystal inflammatory arthritis, and crowned dens syndrome (CDS).MethodsData from an international cohort assembled from 25 sites in 7 countries for the development and validation of the 2023 ACR/EULAR CPPD classification criteria, that met the criteria were included. Three cross‐sectional studies were conducted to determine the phenotypic characteristics of recurrent acute CPP crystal arthritis, chronic CPP crystal inflammatory arthritis, and CDS. Multivariable logistic regression analysis was used to calculate the adjusted odds ratios (aOR) and 95% confidence intervals (CIs) to examine the association between potential risk factors and the inflammatory phenotype.ResultsAmong the 618 people included ((56% female), mean age (standard deviation (S.D.)) 74.0 (11.9) years), 602 (97.4%) had experienced acute CPP crystal arthritis, 332 (53.7%) had recurrent acute arthritis, 158 (25.6%) had persistent inflammatory arthritis, and 45 (7.3%), had had CDS. Recurrent acute CPP crystal arthritis associated with longer disease duration (aOR 2.88 (95%CI 2.00;4.14)). Chronic CPP crystal inflammatory arthritis was associated with ). acute wrist arthritis (aOR(95%CI) 2.92(1.81‐4.73)), metacarpophalangeal (aOR(95% CI) 1.87(1.17‐2.97)) and scapho‐trapezio‐trapezoid (STT) joint osteoarthritis (aOR(95% CI) 1.83(1.15‐2.91)), and negatively associated with either metabolic or familial risk for CPPD (aOR(95% CI) 0.60(0.37‐0.96). CDS was associated with male sex (aOR(95% CI) 2.35(1.21‐4.59)), STT joint osteoarthritis (aOR(95% CI) 2.71(1.22‐6.05)), and more joints affected with chondrocalcinosis (aOR(95% CI) 1.46(1.15‐1.85)).ConclusionsCPPD disease encompasses acute and chronic inflammatory phenotypes, each with specific clinical and imaging features which need to be considered in the diagnostic workup.

show abstract

Features Associated With Different Inflammatory Phenotypes of Calcium Pyrophosphate Deposition Disease: A Study Using Data From the International American College of Rheumatology/EULAR Calcium Pyrophosphate Deposition Classification Criteria Cohort

Pascart,

Latourte,

Tedeschi

et al. 2024

Arthritis & Rheumatology

View full text Add to dashboard Cite

show abstract

Calcium Pyrophosphate Crystal Formation and Deposition: Where Do we Stand and What Does the Future hold?

Sirotti,

Scanu,

Pascart

et al. 2024

Curr Rheumatol Rep

View full text Add to dashboard Cite

Purpose of the review Although calcium pyrophosphate deposition (CPPD) has been known since the 1960s, our understanding of its pathogenesis remains rudimentary. This review aims to illustrate the known mechanisms underlying calcium pyrophosphate (CPP) crystal formation and deposition and explore future directions in research. By examining various perspectives, from basic research to clinical and imaging assessments, as well as new emerging methodologies, we can establish a starting point for a deeper understanding of CPPD pathogenesis. Recent Findings Recent years have seen significant advances in CPPD research, particularly in the clinical field with the development of the 2023 ACR/EULAR classification criteria for CPPD disease, and in imaging with the introduction of the OMERACT ultrasonographic definitions and scoring system. However, progress in basic research has been slower. New laboratory approaches, such as Raman spectroscopy and omics sciences, offer promising insights that may help piece together the puzzle of CPPD. Summary CPPD is a common yet understudied condition. As the population ages and CPPD becomes more prevalent, there is an urgent need to better understand the disease and the mechanisms involved in crystal formation and deposition, in order to improve diagnosis and therapeutic approaches.

show abstract

Calcium pyrophosphate deposition disease

Pascart,

Filippou,

Lioté

et al. 2024

The Lancet Rheumatology

View full text Add to dashboard Cite

Calcium Pyrophosphate and Basic Calcium Phosphate Crystal Arthritis: 2023 in Review

Cited by 5 publications

References 25 publications

Features Associated With Different Inflammatory Phenotypes of Calcium Pyrophosphate Deposition Disease: A Study Using Data From the International American College of Rheumatology/EULAR Calcium Pyrophosphate Deposition Classification Criteria Cohort

Features Associated With Different Inflammatory Phenotypes of Calcium Pyrophosphate Deposition Disease: A Study Using Data From the International American College of Rheumatology/EULAR Calcium Pyrophosphate Deposition Classification Criteria Cohort

Calcium Pyrophosphate Crystal Formation and Deposition: Where Do we Stand and What Does the Future hold?

Calcium pyrophosphate deposition disease

Contact Info

Product

Resources

About