Calcium signalling induced by in vitro exposure to silicium dioxide nanoparticles in rat pulmonary artery smooth muscle cells

Dubes, Virginie; Parpaite, Thibaud; Ducret, Thomas; Quignard, Jean-François; Mornet, Stéphane; Reinhardt, Nora; Baudrimont, Isabelle; Dubois, Mathilde; Freund-Michel, Véronique; Marthan, Roger; Müller, Bernard; Savineau, Jean‐Pierre; Courtois, Arnaud

doi:10.1016/j.tox.2016.12.002

Cited by 23 publications

(27 citation statements)

References 49 publications

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“…In addition, fullerol reversed the TNF-αinduced change in TRPV1 expression and attenuated the [Ca 2+ ] i increase in dorsal root ganglion neurons (Xiao et al, 2018). Other studies have found that some types of TRPV channels (TRPV1, Dubes et al, 2017;Veronesi, de Haar, Roy, & Oortgiesen, 2002;TRPV4, Dubes et al, 2017;Gilardino et al, 2015;and TRPM2, P. Yu et al, 2015) participate in NMs-induced Ca 2+ influx and increasing [Ca 2+ ] i .…”

Section: Trp Channelsmentioning

confidence: 88%

“…Many studies have shown that exposure to NMs increase [Ca 2+ ] i (Cao et al, 2013;E. Y. Chen et al, 2011;Dubes et al, 2017;Huang, Aronstam, Chen, & Huang, 2010;Onodera et al, 2017;Xiang et al, 2016). For example, magnetic NPs triggered Ca 2+ influx via N-type Ca 2+ channels in rat cortical neurons (Tay & Di Carlo, 2017), while other studies have shown that [Ca 2+ ] i does not significantly change after treatment with NMs, such as MWCNTs (Xu et al, 2009).…”

Section: [Ca 2+ ] I Alterationsmentioning

confidence: 99%

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Interactions of nanomaterials with ion channels and related mechanisms

Yin

Liu

Kang

et al. 2019

British J Pharmacology

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The pharmacological potential of nanotechnology, especially in drug delivery and bioengineering, has developed rapidly in recent decades. Ion channels, which are easily targeted by external agents, such as nanomaterials (NMs) and synthetic drugs, due to their unique structures, have attracted increasing attention in the fields of nanotechnology and pharmacology for the treatment of ion channel-related diseases. NMs have significant effects on ion channels, and these effects are manifested in many ways, including changes in ion currents, kinetic characteristics and channel distribution. Subsequently, intracellular ion homeostasis, signalling pathways, and intracellular ion stores are affected, leading to the initiation of a range of biological processes. However, the effect of the interactions of NMs with ion channels is an interesting topic that remains obscure. In this review, we have summarized the recent research progress on the direct and indirect interactions between NMs and ion channels and discussed the related molecular mechanisms, which are crucial to the further development of ion channel-related nanotechnological applications. 1 | INTRODUCTION With the rapid development of nanotechnology, the biological effects of nanomaterials (NMs), ranging in size from 1-100 nm, size range have attracted substantial attention (Ou et al., 2016; L. Wang, Hu, & Shao, 2017). Because of their high surface energy, volume effects, and quantum size effects, NMs have prospective applications in biomedical fields, including biomedical imaging (Rosado-de-Castro,

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Section: Trp Channelsmentioning

confidence: 88%

Section: [Ca 2+ ] I Alterationsmentioning

confidence: 99%

Interactions of nanomaterials with ion channels and related mechanisms

Yin

Liu

Kang

et al. 2019

British J Pharmacology

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“…Accumulating evidence has shown that intracellular Ca 2+ increases after cells are exposed to a variety of nanoparticles ( Dubes et al, 2017 ; Huang et al, 2009 ), and this increase has been associated with the inhibition or activation of various intracellular signaling pathways, leading to a cytotoxic effect. These alterations in Ca 2+ homeostasis lead to persistent, pathologic activation of calpain, which is indicative of cell cytoskeletal injury ( Lu et al, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

Calpain activation and disturbance of autophagy are induced in cortical neurons in vitro by exposure to HA/β-Ga₂O₃:Cr³⁺ nanoparticles

Lei¹,

Wang²,

Jiang³

et al. 2018

PeerJ

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The toxicity of engineered nanoparticles remains a concern. The knowledge of biohazards associated with particular nanoparticles is crucial to make this cutting-edge technology more beneficial and safe. Here, we evaluated the toxicity of Ga2O3 nanoparticles (NPs), which are frequently used to enhance the performance of metal catalysts in a variety of catalytic reactions. The potential inflammatory signaling associated with the toxicity of HA/β-Ga2O3:Cr3+ NPs in primary cortical neurons was examined. We observed a dose-dependent decrease in cell viability and an increase in apoptosis in neurons following various concentrations (0, 1, 5, 25, 50, 100 µg/ml) of HA/β-Ga2O3:Cr3+ NPs treatment. Consistently, constitutively active forms of calcineurin (48 kDa) were significantly elevated in cultured primary cortical neurons, which was consistent with calpain activation indicated by the breakdown products of spectrin. Moreover, HA/β-Ga2O3:Cr3+ NPs result in the elevation of LC3-II formation, SQSTM/p62, and Cathepsin B, whereas phosphorylation of CaMKII (Thr286) and Synapsin I (Ser603) were downregulated in the same context. Taken together, these results demonstrate for the first time that calpain activation and a disturbance of autophagy signaling are evoked by exposure to HA/β-Ga2O3:Cr3+ NPs, which may contribute to neuronal injury in vitro.

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“…Thus, special antagonists of these channels as well as the suppressors of gene expression of TRPV1 may be developed as the potential treatment for patients with IPAH [90–92]. Dubes and coauthors showed that TRPV1 channels are one of the mediators of intracellular Ca 2+ increase in PASMC under silicium oxide nanoparticles loading [93].…”

Section: Trpv1 In Vascular and Visceral Systemsmentioning

confidence: 99%

Multifunctional TRPV1 Ion Channels in Physiology and Pathology with Focus on the Brain, Vasculature, and Some Visceral Systems

Storozhuk

Moroz

Zholos

2019

BioMed Research International

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TRPV1 has been originally cloned as the heat and capsaicin receptor implicated in acute pain signalling, while further research has shifted the focus to its importance in chronic pain caused by inflammation and associated with this TRPV1 sensitization. However, accumulating evidence suggests that, apart from pain signalling, TRPV1 subserves many other unrelated to nociception functions in the nervous system. In the brain, TRPV1 can modulate synaptic transmission via both pre- and postsynaptic mechanisms and there is a functional crosstalk between GABA receptors and TRPV1. Other fundamental processes include TRPV1 role in plasticity, microglia-to-neuron communication, and brain development. Moreover, TRPV1 is widely expressed in the peripheral tissues, including the vasculature, gastrointestinal tract, urinary bladder, epithelial cells, and the cells of the immune system. TRPV1 can be activated by a large array of physical (heat, mechanical stimuli) and chemical factors (e.g., protons, capsaicin, resiniferatoxin, and endogenous ligands, such as endovanilloids). This causes two general cell effects, membrane depolarization and calcium influx, thus triggering depending on the cell-type diverse functional responses ranging from neuronal excitation to secretion and smooth muscle contraction. Here, we review recent research on the diverse TRPV1 functions with focus on the brain, vasculature, and some visceral systems as the basis of our better understanding of TRPV1 role in different human disorders.

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Calcium signalling induced by in vitro exposure to silicium dioxide nanoparticles in rat pulmonary artery smooth muscle cells

Cited by 23 publications

References 49 publications

Interactions of nanomaterials with ion channels and related mechanisms

Interactions of nanomaterials with ion channels and related mechanisms

Calpain activation and disturbance of autophagy are induced in cortical neurons in vitro by exposure to HA/β-Ga₂O₃:Cr³⁺ nanoparticles

Multifunctional TRPV1 Ion Channels in Physiology and Pathology with Focus on the Brain, Vasculature, and Some Visceral Systems

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Calcium signalling induced by in vitro exposure to silicium dioxide nanoparticles in rat pulmonary artery smooth muscle cells

Cited by 23 publications

References 49 publications

Interactions of nanomaterials with ion channels and related mechanisms

Interactions of nanomaterials with ion channels and related mechanisms

Calpain activation and disturbance of autophagy are induced in cortical neurons in vitro by exposure to HA/β-Ga2O3:Cr3+ nanoparticles

Multifunctional TRPV1 Ion Channels in Physiology and Pathology with Focus on the Brain, Vasculature, and Some Visceral Systems

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Calpain activation and disturbance of autophagy are induced in cortical neurons in vitro by exposure to HA/β-Ga₂O₃:Cr³⁺ nanoparticles