Calcium Silicate and Calcium Hydroxide Materials for Pulp Capping: Biointeractivity, Porosity, Solubility and Bioactivity of Current Formulations

Gandolfi, Maria Giovanna; Siboni, Francesco; Botero, Tatiana M.; Bossù, Maurizio; Riccitiello, Francesco; Prati, Carlo

doi:10.5301/jabfm.5000201

Cited by 202 publications

(302 citation statements)

References 47 publications

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“…Islam et al [29] also observed low solubility levels for white PC, in comparison with MTA. On the other hand, Gandolfi et al [33,37,38] showed high solubility levels for ProRoot MTA; moreover, they attributed the high solubility to the long setting time exhibited by the material. These differences may be attributed to the type of PC evaluated in the present study, and to the long setting time (3 times the initial setting time) applied before the solubility test.…”

Section: Discussionmentioning

confidence: 95%

“…Studies showed that the amount of leached calcium decreased with time for calcium silicate materials such as ProRoot MTA, Dycal and TheraCal [37], MTAAngelus [39], and light-cure resin-modified calcium silicate cement [33]. Calcium silicate materials (ProRoot MTA, MTAAngelus, MTA Plus, Biodentine, Tech Biosealer capping, and TheraCal) release more calcium than pulp-capping calcium hydroxide materials (Calxyl, Dycal, Life, and Lime-Lite) [38]. Gandolfi et al [41] showed that ProRoot MTA, MTAAngelus, and Tech Biosealer root-end act as sources of hydroxyl and calcium ions and contribute to creating a calciumrich alkaline environment.…”

Section: Discussionmentioning

confidence: 99%

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Physicochemical properties of calcium silicate cements associated with microparticulate and nanoparticulate radiopacifiers

et al. 2015

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Physicochemical properties of calcium silicate cements associated with microparticulate and nanoparticulate radiopacifiers

et al. 2015

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“…Gandolfi et al reported high releases of calcium and hydroxyl ions in ProRoot MTA and Tech Biosealer Root End 17. In addition, Tech Biosealer Capping released greater amounts of calcium compared to ProRoot MTA, Pulpdent and Dycal 44. Hakki et al evaluated the response of cementoblasts to Tech Biosealer and reported a significant decrease in cell viability 18.…”

Section: Discussionmentioning

confidence: 99%

In vitrocytotoxicity of four calcium silicate-based endodontic cements on human monocytes, a colorimetric MTT assay

et al. 2014

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ObjectivesThis study was performed to evaluate the cytotoxicity of four calcium silicate-based endodontic cements at different storage times after mixing.Materials and MethodsCapillary tubes were filled with Biodentine (Septodont), Calcium Enriched Mixture (CEM cement, BioniqueDent), Tech Biosealer Endo (Tech Biosealer) and ProRoot MTA (Dentsply Tulsa Dental). Empty tubes and tubes containing Dycal were used as negative and positive control groups respectively. Filled capillary tubes were kept in 0.2 mL microtubes and incubated at 37℃. Each material was divided into 3 groups for testing at intervals of 24 hr, 7 day and 28 day after mixing. Human monocytes were isolated from peripheral blood mononuclear cells and cocultered with 24 hr, 7 day and 28 day samples of different materials for 24 and 48 hr. Cell viability was evaluated using an MTT assay.ResultsIn all groups, the viability of monocytes significantly improved with increasing storage time regardless of the incubation time (p < 0.001). After 24 hr of incubation, there was no significant difference between the materials regarding monocyte viability. However, at 48 hr of incubation, ProRoot MTA and Biodentine were less cytotoxic than CEM cement and Biosealer (p < 0.01).ConclusionsBiodentine and ProRoot MTA had similar biocompatibility. Mixing ProRoot MTA with PBS in place of distilled water had no effect on its biocompatibility. Biosealer and CEM cement after 48 hr of incubation were significantly more cytotoxic to on monocyte cells compared to ProRoot MTA and Biodentine.

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“…Here the calcium release from TheraCal LC was significantly more than Dycal. 6 Yet another similar study by Chaudari et al in 2016, Septocal LC was tested as another experimental group along with TheraCal LC. The study reported better calcium releasing property of both the cements.…”

Section: Discussionmentioning

confidence: 99%

“…Though this material has adequate calcium release, it is hydrolytically unstable and is moisture sensitive. 6 Alternate materials such as MTA, white Portland cements are self-setting hydrophilic calcium silicate cements. They exhibit lesser pulpal necrosis, lesser inflammation, more and faster deposition of hard tissue barrier that is more homogenous and complete.…”

Section: Introductionmentioning

confidence: 99%

Histological evaluation of human pulp capped with light-cured calcium based cements: a randomized controlled clinical trial

Gopika¹,

Ramarao²,

Usha³

et al. 2017

Int J Sci Rep

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INTRODUCTIONDirect pulp capping (DPC) is defined as the treatment of a mechanical or traumatic vital pulp exposure by sealing the pulpal wound with a biomaterial placed directly on exposed pulp to facilitate formation of reparative dentin and maintenance of the vitality of pulp.1 Calcium hydroxide has been the gold standard for this purpose.The alkalinity of calcium hydroxide causes superficial necrosis of exposed pulp. This necrosis acts as mild irritation and thus stimulates the pulp to form a reparative dentin bridge. The success rate of calcium hydroxide direct capping was 80.1% after 1 year, 68.0% after 5 years, and 58.7% after 9 years.2 The reason for failure over time is attributed to tunnel defects that form in the bridge. This fails to provide a permanent barrier and a ABSTRACT Background: Calcium hydroxide has traditionally been used as the pulp capping material for pulpal exposures in permanent teeth. The tunnel defects in the barrier and the tendency for dissolution, however, fails to provide permanent protection to the pulp. Light curable resin based cements have been introduced to enable a better marginal seal and lesser dissolution. The purpose of this study was to compare and evaluate the response of human pulp following direct pulp capping with the new resin based Calcium silicate (TheraCal LC) and Calcium hydroxide with hydroxyapatite (Septocal LC) cements compared with calcium hydroxide (Dycal). Methods: 72 intact human premolars scheduled for orthodontic extractions were exposed to direct pulp capping procedures using three different pulp capping agents. Teeth were randomly divided into 3 groups, Group A: Dycal, Group B: TheraCal LC, Group C: Septocal LC. The teeth were extracted at the end of 15 and 40 days' and were evaluated histologically. They were scored for reparative dentin formation and inflammatory response. Inferential statistics was done using Chi square test. Results: Majority of the specimens in all three groups at the end of 15 days' showed partial to lateral deposition of hard tissue. There was continuous deposition of hard tissue and severe inflammatory response at the end of 40 days' in Dycal. There was partial deposition of hard tissue and reduced inflammatory response at the end of 40 days' in TheraCal LC and Septocal LC. However, the results were not statistically significant between the three groups at two different time periods. Conclusions: Light cured, Calcium silicate (TheraCal LC) and Calcium hydroxide with hydroxyapatite (Septocal LC) cements were as effective as calcium hydroxide (Dycal) in inducing the formation of reparative dentin and evoking inflammatory response.

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Calcium Silicate and Calcium Hydroxide Materials for Pulp Capping: Biointeractivity, Porosity, Solubility and Bioactivity of Current Formulations

Cited by 202 publications

References 47 publications

Physicochemical properties of calcium silicate cements associated with microparticulate and nanoparticulate radiopacifiers

Physicochemical properties of calcium silicate cements associated with microparticulate and nanoparticulate radiopacifiers

In vitrocytotoxicity of four calcium silicate-based endodontic cements on human monocytes, a colorimetric MTT assay

Histological evaluation of human pulp capped with light-cured calcium based cements: a randomized controlled clinical trial

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