Calcium spirulan derived from Spirulina platensis inhibits herpes simplex virus 1 attachment to human keratinocytes and protects against herpes labialis

Mader, Julia K.; Gallo, Antonio; Schommartz, Tim; Handke, Wiebke; Nagel, Claus-Henning; Günther, Patrick; Brune, Wolfram; Reich, Kristian

doi:10.1016/j.jaci.2015.07.027

Cited by 82 publications

(60 citation statements)

References 35 publications

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“…SCEM exhibited antiviral activity against HCV and this was in agreement with other study which showed the antiviral activities of water extract of S. platensis against hepatitis A and herpes simplex viruses [8] as well as the antiviral activity of calcium spirulan (Ca-SP) which exhibited a strong inhibitory against several enveloped viruses, by targeting the viral absorption/penetration and some replication stages after penetration into cells [12,32]. Moreover, a comparative clinically trial of S. platensis revealed that Spirulina decrease more significantly the HCV virus load at least 2-log 10 and also significantly improved alanine aminotransferase [9].…”

Section: Discussionsupporting

confidence: 90%

“…Among these polysaccharides, calcium spirulan (Ca-SP) exhibited strong inhibitory effect against some enveloped viruses [12], beside it could suppress the replication of herpes simplex, mumps, measles, influenza A viruses and cytomegalovirus [13]. In addition to inhibit metastasis of mouse B16 melanoma cells [14], the polysaccharide from Spirulina species acts as hepatoprotectant against malignant cell [15].…”

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confidence: 99%

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In vitro assessment of anti-HCV, antioxidant, cytotoxic and hypolipidemic activities of glycoprotein isolated from Spirulina platensis

Matloub¹,

El‐Senousy²,

El-Sayed³

et al. 2017

APJTD

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Section: Discussionsupporting

confidence: 90%

mentioning

confidence: 99%

In vitro assessment of anti-HCV, antioxidant, cytotoxic and hypolipidemic activities of glycoprotein isolated from Spirulina platensis

Matloub¹,

El‐Senousy²,

El-Sayed³

et al. 2017

APJTD

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“…; König ; Mader et al . ). Ganc was found to inhibit mammalian cell proliferation in vitro at IC 50 concentrations ranging from 10.21 to >250 μg mL −1 (FDA ).…”

Section: Discussionmentioning

confidence: 97%

“…; König ; Mader et al . ). However, the IC 50 was approximately 4 to 10‐times higher than determined for the extracellular fractions.…”

Section: Discussionmentioning

confidence: 97%

Antiviral activity of exopolysaccharides from Arthrospira platensis against koi herpesvirus

Reichert¹,

Bergmann

Hwang

et al. 2017

Journal of Fish Diseases

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Although koi herpesvirus (KHV) has a history of causing severe economic losses in common carp and koi farms, there are still no treatments available on the market. Thus, the aim of this study was to test exopolysaccharides (EPS) for its antiviral activity against KHV, by monitoring inhibition and cytotoxic effects in common carp brain cells. These substances can be easily extracted from extracellular algae supernatant and were identified as groups of sulphated polysaccharides. In order to reach this aim, Arthrospira platensis, which is well known for its antiviral activity of intra- and extracellular compounds towards mammalian herpesviruses, was investigated as standard organism and compared to commercial antiviral drug, ganciclovir, which inhibits the viral DNA polymerization. The antiviral activity of polysaccharides of A. platensis against KHV was confirmed in vitro using qualitative assessment of KHV life cycle genes, and it was found by RT-PCR that EPS, applied at a concentration of >18 μg mL and a multiplicity of infection (MOI) of 0.45 of KHV, suppressed the viral replication in common carp brain (CCB) cells even after 22 days post-infection, entirely. Further, this study presents first data indicating an enormous potential using polysaccharides as an additive for aquacultures to lower or hinder the spread of the KHV and koi herpesvirus disease (KHVD) in future.

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“…For example, Spirulina has well-known culture conditions and has been used in food formulations or extraction of biocomposites. Studies have shown different biological actions can be identified on components of this microalga and its antifungal and antibacterial properties have being exploited [5,34,97,98].…”

Section: Microalgae As Potential Source Of Preservativesmentioning

confidence: 99%

Can Microalgae Act as Source of Preservatives in Food Chain?

Scaglioni¹,

Badiale‐Furlong²

2017

JFSE

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Microalgae are a potential source for various valuable chemicals for commercial applications ranging from nutraceuticals to fuels. This review aims to focus on microalgal as preservative potential to food chain. The main compounds responsible for these properties, like carotenoids, phenolic compounds, antioxidant vitamins, sterols and polyunsaturated fatty acids are discussed because microalgae can be cultivated under controlled conditions to improve their production. We have listed several studies performed in recent years supporting the health benefits that most of these compounds can provide. Therefore, they may represent an excellent source of preservatives in food chain once their safety as a food supplement has been also confirmed.

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Calcium spirulan derived from Spirulina platensis inhibits herpes simplex virus 1 attachment to human keratinocytes and protects against herpes labialis

Abstract: These data indicate a potential clinical use of Ca-SP containing Spirulina species extract for the prophylactic treatment of herpes labialis and suggest possible activity of Ca-SP against infections caused by other herpesviruses.

Cited by 82 publications

References 35 publications

In vitro assessment of anti-HCV, antioxidant, cytotoxic and hypolipidemic activities of glycoprotein isolated from Spirulina platensis

In vitro assessment of anti-HCV, antioxidant, cytotoxic and hypolipidemic activities of glycoprotein isolated from Spirulina platensis

Antiviral activity of exopolysaccharides from Arthrospira platensis against koi herpesvirus

Can Microalgae Act as Source of Preservatives in Food Chain?

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