Calcium Supplementation to Prevent Hypertensive Disorders of Pregnancy

Belizán, José M.; Villar, José; González, L.; Campodónico, Liana; Bergel, Eduardo

doi:10.1056/nejm199111143252002

Cited by 253 publications

(81 citation statements)

References 24 publications

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“…Recent evidence suggests that calcium could also increase magnesium levels and have an effect on smooth muscle function of the uteroplacental blood flow 17 . Despite the results of some previous studies about a relation between calcium supplementation and gestational age and lower rates of preterm birth 18,19 , our finding showed that there are no differences in pregnancy outcome such as preterm birth, low birth weight, NICU admission, and low Apgar scores between the two groups.…”

Section: Discussioncontrasting

confidence: 99%

Calcium supplementation in pregnancy and prevention of hypertensive disorders in elderly women

Aghamohammadi¹,

Zafari²

2015

ScienceAsia

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Preeclampsia is a major cause of maternal and neonatal death and morbidity. Elderly women are at high risk for this complication. This study assesses the effect of calcium supplementation during pregnancy on preeclampsia in women aged over 35. Singleton healthy pregnant women over 35 with a normal blood pressure were randomly assigned to receive 1000 mg/day of elemental calcium or placebo between the 18th and 20th weeks. From 89 women recruited in this study, 5 women in the calcium group and 4 women in the placebo group were excluded during the treatment as it was not possible to follow up their status. Finally, 80 women completed this study and were followed up until delivery. The incidence of preeclampsia was assessed in these 80 women (40 women in placebo and 40 women in the calcium group). The incidence of preeclampsia was significantly lower in the calcium group (15%) than in the placebo group (35%) (p = 0.035). Calcium supplementation appears to reduce the occurrence of preeclampsia and its related preterm birth in women singletons.

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Section: Discussioncontrasting

confidence: 99%

Calcium supplementation in pregnancy and prevention of hypertensive disorders in elderly women

Aghamohammadi¹,

Zafari²

2015

ScienceAsia

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“…Furthermore, intake of calcium has been shown to correlate inversely with blood pressure in clinical and experimental studies (9), although some contradictory results have also been published (10). Calcium supplementation has also been suggested to decrease blood pressure in human hypertension, and certain types of hypertensive patients, including those with hypertensive disorders of pregnancy and salt-sensitive individuals, may be more susceptible to the blood pressure-lowering action (11).…”

Section: Introductionmentioning

confidence: 99%

High Blood Pressure, Bone-Mineral Loss and Insulin Resistance in Women

et al. 2005

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“…We therefore consider supplementation at 20 weeks to be benefi cial. [19][20][21] Still unproven (unknown, not enough evidence)…”

Section: Calciummentioning

confidence: 99%

Prevention of Preeclampsia: Is it Still a Disappointment?

Eddib

Yeh

2009

Clinical medicine. Women's health

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Preeclampsia is a major cause of maternal mortality worldwide, with many preventive strategies tested. In this review we intend to provide a synthesis of available studies of these strategies that have been tested, including systematic reviews. We will not be performing systematic review of the studies here. Of these strategies tested only low dose acetyl salicylic acid (ASA) and calcium can be considered helpful for prevention at this time. A recent meta-analysis showed a benefi t of low dose ASA for both high (RR 0.75, 95% CI 0.66 to 0.85) and moderate risk groups (RR 0.86, 95% CI 0.79 to 0.95). Therefore, low dose ASA in high risk groups may be useful, with a possible smaller benefi t in moderate to low risk women. Another meta-analysis looking at calcium shows benefi t for both high and low risk groups with an overall reduction in the risk of preeclampsia (RR 0.48, 95% CI 0.33 to 0.69). As a result, prenatal supplementation of calcium may be benefi cial for the prevention of preeclampsia. However, vitamins C and E, zinc, fi sh oil, and magnesium supplementation have been discounted as potential preventive strategies. Nitric oxide, folic acid, and antithrombotics have not been well studied and there is insuffi cient data for reliable conclusions to be made. Areas of ongoing research that appear promising in the prevention of preeclampsia include modifi able metabolic factors, angiogenic proteins, angiotensin receptor antibodies, and syncytiotrophoblast microparticles. Strategies targeting these areas may provide opportunities for therapeutic interventions.

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Calcium Supplementation to Prevent Hypertensive Disorders of Pregnancy

Abstract: Pregnant women who receive calcium supplementation after the 20th week of pregnancy have a reduced risk of hypertensive disorders of pregnancy.

Cited by 253 publications

References 24 publications

Calcium supplementation in pregnancy and prevention of hypertensive disorders in elderly women

Calcium supplementation in pregnancy and prevention of hypertensive disorders in elderly women

High Blood Pressure, Bone-Mineral Loss and Insulin Resistance in Women

Prevention of Preeclampsia: Is it Still a Disappointment?

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