2000
DOI: 10.1054/ceca.2000.0111
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Calcium uptake, release and ryanodine binding in melanosomes from retinal pigment epithelium

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Cited by 51 publications
(45 citation statements)
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“…(51) It has been suggested that melanosomes regulate calcium concentration within the retinal pigment epithelium. (52) Further, Ca 2þ released from the lumen of mammalian endocytic compartments and lysosomes mediates membrane fusion and efficient membrane trafficking in the endocytic pathway, (28,53) (56,57) and calcium carbonate containing inner ear otoliths in mocha, muted and pallid.…”
Section: Platelet Dense Granulesmentioning
confidence: 99%
“…(51) It has been suggested that melanosomes regulate calcium concentration within the retinal pigment epithelium. (52) Further, Ca 2þ released from the lumen of mammalian endocytic compartments and lysosomes mediates membrane fusion and efficient membrane trafficking in the endocytic pathway, (28,53) (56,57) and calcium carbonate containing inner ear otoliths in mocha, muted and pallid.…”
Section: Platelet Dense Granulesmentioning
confidence: 99%
“…More importantly, RPE cells were found to take up Ca 2+ [45]. Moreover, Ca 2+ uptake was found to be dependent on the degree of pigmentation of the RPE [46], and further studies showed Ca 2+ uptake and release by melanosomes (see, e.g., [47]). …”
Section: Figmentioning
confidence: 99%
“…exchanger has been proposed. Such activity has been measured in isolated melanosomes from retinal pigment epithelial cells [314] and large dense core granules in PC12 cells [309]. In the latter cell type, however, as well as in many other cells, our group failed to measure a DH ?…”
Section: Acidic Compartmentsmentioning
confidence: 91%
“…Additionally, caffeine (a pharmacological activator of RyRs) was shown to mediate Ca 2? release from isolated melanosomes [314]. But the most potent Ca 2?…”
Section: Acidic Compartmentsmentioning
confidence: 99%