Calculation of complex DNA damage induced by ions

Surdutovich, Eugene; Gallagher, David C.; Solov’yov, Andrey V.

doi:10.1103/physreve.84.051918

Cited by 30 publications

(46 citation statements)

References 32 publications

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“…In this analytical approach, the key quantity is the flux of secondary electrons through a patch dA located at a distance r from a segment dζ of the ion trajectory from which the secondary electrons originate. It is given by 2 [17,18]:…”

Section: Analytical Approachmentioning

confidence: 99%

Nanoscale characterization of ion tracks: MC simulations versus analytical approach

et al. 2012

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The goal of this work was to investigate the agreement of physical parameters related to the particle track structure on the nanometer scale, obtained by means of a detailed track structure simulation (PTra) as well as by a rapid analytical approach. Parameters describing the tracks of secondary electrons produced by 0.3 MeV/ u C6+-ions were of particular interest as those particles are densely ionizing. For this purpose, the target volume in form of a nanometric water cylinder was positioned at different radial distances from the ion trajectory and track structure parameters were determined as function of the radial distance. While the fluence of electrons through the target surface and the mean ionization cluster size obtained by both approaches were in good agreement, the probabilities of specific cluster sizes (one, two and three) turned out to be rather different in the two approaches. Abstract. The scope of this work was to investigate the agreement of physical parameters related to the particle track structure on the nanometer scale, obtained by means of a detailed track structure simulation (PTra) as well as by a rapid analytical approach. Parameters describing the tracks of secondary electrons produced by 0.3 MeV/u C 6+ -ions were of particular interest as those particles are densely ionizing. For this purpose, the target volume in form of a nanometric water cylinder was positioned at different radial distances from the ion trajectory and track structure parameters were determined as function of the radial distance. While the fluence of electrons through the target surface and the mean ionization cluster size obtained by both approaches were in good agreement, the probabilities of specific cluster sizes (one, two and three) turn out to be rather different in the two approaches.

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Section: Analytical Approachmentioning

confidence: 99%

Nanoscale characterization of ion tracks: MC simulations versus analytical approach

et al. 2012

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“…Thermomechanical effects of these shock waves on the radiation damage have been studied in references [14,15]. Several works were devoted to the DNA damage mechanisms, for example clustered damage [16] and double ionization events [17]. Finally, the multiscale approach has been synthesised in reference [1], where the damage probability curves were obtained for plasmid DNA and a 'recipe' for the calculation of the survival curves for real cells was suggested.…”

Section: Introductionmentioning

confidence: 99%

Nano-scale processes behind ion-beam cancer therapy

et al. 2016

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Abstract. This topical issue collates a series of papers based on new data reported at the third Nano-IBCT Conference of the COST Action MP1002: Nanoscale Insights into Ion Beam Cancer Therapy, held in Boppard, Germany, from October 27th to October 31st, 2014. The Nano-IBCT COST Action was launched in December 2010 and brought together more than 300 experts from different disciplines (physics, chemistry, biology) with specialists in radiation damage of biological matter from hadron-therapy centres, and medical institutions. This meeting followed the first and the second conferences of the Action held in October 2011 in Caen, France and in May 2013 in Sopot, Poland respectively. This conference series provided a focus for the European research community and has highlighted the pioneering research into the fundamental processes underpinning ion beam cancer therapy.

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“…The complexity of ion-beam interactions with living matter makes it difficult to provide only experimental data sets for treatment planning, therefore theoretical models and simulation methods are indispensable to describe the relevant * Corresponding author: ias@ua.es processes concerned in the biodamage by ion irradiation [6][7][8]. Recently a multiscale approach to tackle this intricate problem, where different events happen on many spatial, temporal, and energetic scales, has been proposed [9,10].…”

Section: Introductionmentioning

confidence: 99%

Energy deposition of H and He ion beams in hydroxyapatite films: A study with implications for ion-beam cancer therapy

et al. 2014

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Ion-beam cancer therapy is a promising technique to treat deep-seated tumors; however, for an accurate treatment planning, the energy deposition by the ions must be well known both in soft and hard human tissues. Although the energy loss of ions in water and other organic and biological materials is fairly well known, scarce information is available for the hard tissues (i.e., bone), for which the current stopping power information relies on the application of simple additivity rules to atomic data. Especially, more knowledge is needed for the main constituent of human bone, calcium hydroxyapatite (HAp), which constitutes 58% of its mass composition. In this work the energy loss of H and He ion beams in HAp films has been obtained experimentally. The experiments have been performed using the Rutherford backscattering technique in an energy range of 450-2000 keV for H and 400-5000 keV for He ions. These measurements are used as a benchmark for theoretical calculations (stopping power and mean excitation energy) based on the dielectric formalism together with the MELF-GOS (Mermin energy loss function-generalized oscillator strength) method to describe the electronic excitation spectrum of HAp. The stopping power calculations are in good agreement with the experiments. Even though these experimental data are obtained for low projectile energies compared with the ones used in hadron therapy, they validate the mean excitation energy obtained theoretically, which is the fundamental quantity to accurately assess energy deposition and depth-dose curves of ion beams at clinically relevant high energies. The effect of the mean excitation energy choice on the depth-dose profile is discussed on the basis of detailed simulations. Finally, implications of the present work on the energy loss of charged particles in human cortical bone are remarked.

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Calculation of complex DNA damage induced by ions

Cited by 30 publications

References 32 publications

Nanoscale characterization of ion tracks: MC simulations versus analytical approach

Nanoscale characterization of ion tracks: MC simulations versus analytical approach

Nano-scale processes behind ion-beam cancer therapy

Energy deposition of H and He ion beams in hydroxyapatite films: A study with implications for ion-beam cancer therapy

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