Calculus Renal Failure

Abstract

Background: Urolithiasis is a common urological disease in Pakistan. Calculusrenal failure is a urological emergency that required immediate intervention to prevent furtherdeterioration of renal function. Objectives: The purpose of this study is to present clinical profileof calculus renal failure patient and to report our experience of management of such patients.Study Design: Descriptive Cross sectional study. Setting and Period: Department of urologyServices Hospital from July 2015 to December 2016 were included. Materials and Methods:Patients of all ages of either sex who presented with calculus renal failure. The patients withobstructive uropathy due to causes other than stone disease were excluded. Demographicinformation along with detailed history recorded. Baseline investigations included Completeblood counts, serum creatinine, serum electrolytes and ultrasound for KUB. For stone positionXray KUB in every case & CT in selected cases performed. Functional status of individual kidneywas assessed by renal scan with differential GFR. After initial emergency treatment, all patientswere subjected to definite treatment depending upon stone location and functional status ofkidney. Results: A total of 68 patients were recruited for this study. The mean age of the patientswas 48.8 + 14.13 with range 23-90. 52(76.5%) of the patients were male and 16(23.5%)were females. Most common presentation was lumber pain 46 (67.6%) followed by anorexia 42(61.8%). The average presence of the symptoms was 17.70 days. At initial management of thecondition contained, 16(23.5%) of the patients managed by peritoneal dialysis /Hemodialysis,10(14.7%) by unilateral PCN, 16(23.5%) by Bilateral PCN, unilateral JJ stenting done in 8(11.8%)while bilateral JJ stenting in 07 (10.9%), 6(8.8%). 10(14.7%) patient were managed with URS/Lithoclast therapy without any prior diversion. Renal function in 08 patients (11.8%) did notimproved after initial management and they remained on maintenance dialysis. Conclusion: Intime diagnosis and early proper treatment improves the outcome.

Investigating diagnostic, Prognostic, and therapeutic role of Long Non-Coding RNA MALAT1 in Breast Carcinoma:<i> in silico</i> study

“…The role of lncRNA may be identified and understood with the important assistance of the ceRNA hypothesis [10]. The LncRNA expression profile in BC is often dysregulated, and several LncRNAs, including LINC01133, ZEB1-AS1, and ABHD11-AS1, have been linked to BC carcinogenesis [11].…”