Callosotomy and subsequent surgery for children with refractory epilepsy

Ono, Tomonori; Baba, Hiroshi; Toda, Keisuke; Ono, Ken

doi:10.1016/j.eplepsyres.2010.12.011

Cited by 39 publications

(51 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent research suggested that generalized epileptic discharges could result from coupling/resonance between cortical focus and subcortical structures (Lüttjohann and van Luijtelaar 2015;Meeren et al 2005). Disconnection of corpus callosum could disrupt rapid spread of epileptic discharges from the unilateral focus to the contralateral hemisphere and prevent a full blown generalized seizure (Chen et al 2015;Clarke et al 2007;Hur et al 2011;Iwasaki et al 2011;Lin et al 2011;Ono et al 2011). However, after CC, ictal onset zone in the leading hemisphere may remain very broad in some patients.…”

Section: Discussionmentioning

confidence: 98%

“…These evidences suggest the possibility that some generalized seizures could be developed by a complex epileptogenic network involving both local and global brain networks (Blumenfeld et al 2003;Lüttjohann and van Luijtelaar 2015;McNally and Blumenfeld 2004). Furthermore, by interrupting the global network through corpus callosotomy (CC), several clinical studies have demonstrated the possibility of revealing focal seizure onset in scalp EEG (Clarke et al 2007;Hur et al 2011;Iwasaki et al 2011;Lin et al 2011;Ono et al 2011).…”

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Identification of Focal Epileptogenic Networks in Generalized Epilepsy Using Brain Functional Connectivity Analysis of Bilateral Intracranial EEG Signals

Chen

Castillo

Baumgartner³

et al. 2016

Brain Topogr

View full text Add to dashboard Cite

Simultaneous bilateral onset and bi-synchrony epileptiform discharges in electroencephalogram (EEG) remain hallmarks for generalized seizures. However, the possibility of an epileptogenic focus triggering rapidly generalized epileptiform discharges has been documented in several studies. Previously, a new multi-stage surgical procedure using bilateral intracranial EEG (iEEG) prior to and post complete corpus callosotomy (CC) was developed to uncover seizure focus in non-lateralizing focal epilepsy. Five patients with drug-resistant generalized epilepsy who underwent this procedure were included in the study. Their bilateral iEEG findings prior to complete CC showed generalized epileptiform discharges with no clear lateralization. Nonetheless, the bilateral ictal iEEG findings post complete CC indicated lateralized or localized seizure onset. This study hypothesized that brain functional connectivity analysis, applied to the pre CC bilateral iEEG recordings, could help identify focal epileptogenic networks in generalized epilepsy. The results indicated that despite diffuse epileptiform discharges, focal features can still be observed in apparent generalized seizures through brain connectivity analysis. The seizure onset localization/lateralization from connectivity analysis demonstrated a good agreement with the bilateral iEEG findings post complete CC and final surgical outcomes. Our study supports the role of focal epileptic networks in generalized seizures.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 98%

Identification of Focal Epileptogenic Networks in Generalized Epilepsy Using Brain Functional Connectivity Analysis of Bilateral Intracranial EEG Signals

Chen

Castillo

Baumgartner³

et al. 2016

Brain Topogr

View full text Add to dashboard Cite

show abstract

“…8,9 We started with bilateral iEEG as first step because of its non-destructiveness and proven efficacy of seizure localization. 3,4 With bilateral iEEG alone, we were able to localize resectable foci in 17 out of 30 cases with similar pre-surgical findings and confirmed 4 patients with bilateral independent foci.…”

Section: Discussionmentioning

confidence: 99%

“…5 In addition, because CC prevents rapid secondary bisynchrony and generalization of seizure activities, several studies have shown that CC can help reveal resectable epileptogenic focus. [6][7][8][9][10] We studied the efficacy and safety of a new multi-stage surgical procedure that utilizes bilateral iEEG monitoring before and after complete CC to lateralize or localize seizure focus for surgical treatment within a single hospital stay.…”

Section: Introductionmentioning

confidence: 99%

Bilateral intracranial EEG with corpus callosotomy may uncover seizure focus in nonlocalizing focal epilepsy

Chen

Baumgartner²,

Seo³

et al. 2015

Seizure

View full text Add to dashboard Cite

show abstract

“…16,17 Further, presurgical evaluation after CC may identify a resectable focus in some patients; favorable seizure outcome can be obtained from subsequent surgery following CC. 18,19 …”

Section: Discussionmentioning

confidence: 99%

Corpus callosotomy for treatment of pediatric refractory status epilepticus

Greiner

Tillema

Hallinan

et al. 2012

Seizure

View full text Add to dashboard Cite

Medically refractory status epilepticus (RSE) causes high morbidity and mortality in children. There are no evidence-based guidelines for treatment. Epilepsy surgery is a treatment option for RSE. We describe a 9-year-old boy treated successfully for RSE with complete corpus callosotomy (CC). Epilepsy surgery should be considered for prolonged RSE. In the absence of evidence of focal epileptogenesis, complete corpus callosotomy may be effective in select cases.

show abstract

Callosotomy and subsequent surgery for children with refractory epilepsy

Cited by 39 publications

References 44 publications

Identification of Focal Epileptogenic Networks in Generalized Epilepsy Using Brain Functional Connectivity Analysis of Bilateral Intracranial EEG Signals

Identification of Focal Epileptogenic Networks in Generalized Epilepsy Using Brain Functional Connectivity Analysis of Bilateral Intracranial EEG Signals

Bilateral intracranial EEG with corpus callosotomy may uncover seizure focus in nonlocalizing focal epilepsy

Corpus callosotomy for treatment of pediatric refractory status epilepticus

Contact Info

Product

Resources

About