Calls for more detailed studies on toxoplasmosis

Kirby, Tony

doi:10.1016/s1473-3099(12)70303-1

Cited by 12 publications

(10 citation statements)

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“…The large burden on health care systems as a result of ocular toxoplasmosis is illustrated e.g. by an estimated 250,000 patient visits to ophthalmologists in the USA alone [2]. …”

Section: Epidemiologymentioning

confidence: 99%

Ocular Toxoplasmosis: Recent Aspects of Pathophysiology and Clinical Implications

Pleyer

Schlüter

Mänz³

2014

Ophthalmic Res

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Toxoplasma gondii is an extremely successful opportunistic parasite which infects approximately one third of the human population worldwide. The impact of this parasite on human health becomes particularly manifest in congenital damage with infection and subsequent inflammation of neuronal tissues including the retina. Although advances in our understanding could be achieved in ocular toxoplasmosis, large gaps still exist on factors influencing the epidemiology and pathophysiology of this potentially blinding disease. We are only at the beginning of understanding the complex biology of this parasite and its mechanisms of invasion, virulence and interaction with the host's immune response. Since it is a preventable cause of blindness, it is necessary to assess factors that have the potential to control this disease in the future. This mini review will focus on recent advances in postnatal acquired ocular infection and the factors that may influence its prevalence and functional outcome.

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“…The large burden on health care systems as a result of ocular toxoplasmosis is illustrated e.g. by an estimated 250,000 patient visits to ophthalmologists in the USA alone [2]. …”

Section: Epidemiologymentioning

confidence: 99%

Ocular Toxoplasmosis: Recent Aspects of Pathophysiology and Clinical Implications

Pleyer

Schlüter

Mänz³

2014

Ophthalmic Res

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“…The large burden on health care systems for OT is illustrated by an estimated 250,000 patient visits to ophthalmologists each year in the USA alone [23]. Recent data estimate the occurrence of ocular lesions due to toxoplasmosis in 21,505 people per year in the USA, where between 2,150 and 7,527 individuals per year may develop symptomatic cases of OT [24].…”

Section: Introductionmentioning

confidence: 99%

Screening for common eye diseases in the elderly with Optos ultra-wide-field scanning laser ophthalmoscopy: a pilot study with focus on ocular toxoplasmosis

et al. 2021

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Purpose Studies on the occurrence of ocular toxoplasmosis (OT) in a general population are rare. Therefore, we conducted this pilot study to assess whether a nonmydriatic ultra-wide-field (UWF) scanning laser ophthalmoscope (SLO) is suitable for a simple, rapid screening procedure. Methods The population of this cross-sectional study was randomly recruited from a cohort of hospital-based patients in an urban geriatric hospital. Ophthalmologic evaluation was performed on 201 eyes from 101 participants through nonmydriatic UWF-SLO (Optos Daytona) and assessed for suspicious lesions and other relevant ocular findings. All images were evaluated by two independent examiners. Individuals who presented lesions with a morphological appearance suggestive of OT underwent fundoscopy and serological analysis of Toxoplasma gondii-specific antibodies. Results The mean age of the study group was 76 years, and 63 (62%) were female. Despite many health restrictions, the SLO examination was carried out easily in this geriatric population. Three participants presented findings by SLO suspicious for T. gondii-related injury. Further clinical examination and serological investigation confirmed the diagnosis, with funduscopic evaluation and positive T. gondii ELISA testing. In addition, a high rate of arterial hypertension and dyslipidemias within the cohort led to a high incidence of vascular changes and age-related fundus findings. Conclusion In our study, we confirm that UWF-SLO technology is helpful in the rapid detection of peripheral retinal injuries in elderly patients such as OT and may be used as a routine screening tool.

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“…The worldwide prevalence of antibodies against T. gondii varies from 30 to 60% in both developing and developed countries [4]. Infection is acquired by accidentally ingesting oocysts in food, water, and soil contaminated with cat faeces or the consumption of raw meat containing tissue cysts [5, 6]. …”

Section: Introductionmentioning

confidence: 99%

Toxoplasmosis seroprevalence in Iranian women and risk factors of the disease: a systematic review and meta-analysis

et al. 2017

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BackgroundToxoplasmosis is caused by an intracellular obligatory parasite, Toxoplasma gondii, and it has global distribution. The purposes of this systematic review and meta-analysis were to evaluate the seroprevalence of toxoplasmosis in Iranian pregnant women, and girls and women of childbearing age, and identify potentially preventable risk factors.MethodsBetween November 2014 and February 2017, nine electronic databases that reported data on the T. gondii seroprevalence in Iranian women were searched. Our search resulted in 83 reports published from 1994 to 2017.ResultsThe results showed that the pooled estimation for the prevalence of T. gondii using a random-effect model was 43% (95% confidence interval (CI) = 38–48%) in pregnant women and 33% (95% CI = 23–43%) in girls and the childbearing age groups. There was a significant association between the T. gondii seroprevalence with age and the gestational age of conception in pregnant women and those who had contact with cats in both groups.ConclusionsThis is the first comprehensive systematic review of T. gondii infection seroprevalence in Iranian women, which showed a high prevalence of Toxoplasma infection. Around 57% of pregnant women and 67% of girls and the childbearing age groups were seronegative and thus were susceptible to infection and should be monitored.Electronic supplementary materialThe online version of this article (doi:10.1186/s41182-017-0048-7) contains supplementary material, which is available to authorized users.

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Calls for more detailed studies on toxoplasmosis

Cited by 12 publications

References 0 publications

Ocular Toxoplasmosis: Recent Aspects of Pathophysiology and Clinical Implications

Ocular Toxoplasmosis: Recent Aspects of Pathophysiology and Clinical Implications

Screening for common eye diseases in the elderly with Optos ultra-wide-field scanning laser ophthalmoscopy: a pilot study with focus on ocular toxoplasmosis

Toxoplasmosis seroprevalence in Iranian women and risk factors of the disease: a systematic review and meta-analysis

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