Calotropis induced ocular toxicity

Waikar, Shrikant; Srivastava, Vinay Kumar

doi:10.1016/j.mjafi.2012.08.017

Cited by 20 publications

(16 citation statements)

References 6 publications

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“…None of our patients had secondary glaucoma, as was also observed by Waikar et al and Lakhtakia et al [11,12] Basak et al found secondary glaucoma in 24.1% of their patients. The raised intraocular pressure could be secondary to iridocyclitis [11].…”

Section: Discussionsupporting

confidence: 88%

“…Waikar et al found increased corneal thickness in affected eye as compared to the normal fellow eye on pachymetry. Specular microscopy in their cases revealed low endothelial cell count with pleomorphism and polymegathism in affected eye as compared to normal fellow eye [11]. These findings suggest that the cause of corneal oedema is endothelial toxicity.…”

Section: Discussionmentioning

confidence: 88%

“…8 patients [25%] in our study presented with epithelial defect along with stromal oedema and Descemets membrane folds. The epithelial damage may be the result of mechanical trauma due to rubbing, or due to the acid injury as suggested by Waikar et al, who found epithelial defect in 15% of their patients [11]. They have suggested the mechanism of Calotropis induced ocular manifestations to be due to two reasons, the first being the acidic nature of the milky sap and second due to the toxins present in the sap.…”

Section: Discussionmentioning

confidence: 93%

“…The resolution of keratitis with local corticosteroid use corroborates this notion. presence of histamine and prostaglandins in the sap may the cause of iridocyclitis [11].…”

Section: Discussionmentioning

confidence: 99%

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Calotropis procera induced ocular toxicity, manifestations and management – an observational study

Pandey

Sahu

2015

Int J Med Res Rev

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Introduction: Calotropis procera produces copious amounts of latex, which possesses several pharmacological properties. It produces severe inflammatory response on local application and its accidental instillation in the eye is associated with significant ocular morbidity. This is an observational study to assess the ocular toxicity of the latex of Calotropis procera and its management. Methods: 34 patients presenting to the ophthalmology department of a tertiary care centre of central India with exposure to the latex of Calotropis procera, were included in the study. Results: The main symptoms reported were burning, watering and discomfort. Corneal edema with striate keratopathy was found to be a universal manifestation with or without epithelial lesions and intraocular inflammation.The keratopathy showed good response to topical corticosteroids. Conclusion: Exposure to the latex of Calotropis procera is associated with significant ocular morbidity. The typical manifestation of striate keratopathy resolves with topical steroids. Simple health education in the form of hand washing, and avoiding eye contact and eye rubbing while plucking the flowers and leaves of Calotropis can prevent this injury.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 93%

“…The resolution of keratitis with local corticosteroid use corroborates this notion. presence of histamine and prostaglandins in the sap may the cause of iridocyclitis [11].…”

Section: Discussionmentioning

confidence: 99%

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Calotropis procera induced ocular toxicity, manifestations and management – an observational study

Pandey

Sahu

2015

Int J Med Res Rev

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“…[4] Topical application of Calotropis latex produces ocular and dermal toxicities. [10] Due to their easy accessibility, availability and relatively low cost, medicinal plants are relied upon for the primary health care needs of some 80% of the population in developing countries. [11] This use is on the rise as a result of the efficacy of some of these medicinal plant materials and misconceptions that since they are natural, they should be safer than synthetic drugs.…”

Section: Introductionmentioning

confidence: 99%

An Experimental Study of the Toxicity Effects of Calotropis Procera (Aiton) Asclepiadaceae in Sprague-Dawley Rats

Aderounmu¹

2017

WJPR

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Calotropis procera Aiton (Calotropis) is a wild-growing plant used for a variety of disease conditions such as leprosy, ulcers, tumor and healing of wounds. The present study was conceived to evaluate the toxicological effect of the latex following systemic use in SpragueDawley rats with a view to understanding its potential safety in treating wounds and preventing keloid formation in human. Haematological evaluation revealed a significant and progressive reduction of the packed cell volume (PCV) and red blood cell count at high doses of the latex. There was no significant effect on the differential count except for lymphocytes which showed significant reduction following increasing concentrations of the latex. Similarly, the latex exhibited no significant effect on the renal indices of the rats: uric acid, urea and creatinine levels. A significant (P<0.05) decrease in blood glucose was decrease at the same dose, but there was no significant change in the levels of the albumin, alanine transaminases and alkaline phosphatases in all the treated groups. Histopathological studies showed no remarkable effect on the tested organs except for the testes where there was destruction of the seminiferous tubules. In conclusion, these results suggest that Calotropis latex is relatively safe when used acutely especially through the oral route and in lower doses when administered through the intra-peritoneal route in rats. However, there is need for caution when higher doses are administered because of the toxic effects on the genitourinary systems particularly in males.

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Chemistry, Biological Activities, and Uses of Calotropis Latex

Bankole

Thiemann

2022

Reference Series in Phytochemistry

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Calotropis induced ocular toxicity

Cited by 20 publications

References 6 publications

Calotropis procera induced ocular toxicity, manifestations and management – an observational study

Calotropis procera induced ocular toxicity, manifestations and management – an observational study

An Experimental Study of the Toxicity Effects of Calotropis Procera (Aiton) Asclepiadaceae in Sprague-Dawley Rats

Chemistry, Biological Activities, and Uses of Calotropis Latex

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