Calpain-10 gene polymorphisms and type 2 diabetes in West Africans: the Africa America Diabetes Mellitus (AADM) Study

Chen, Yuanxiu; Kittles, Rick A.; Zhou, Jie; Chen, Guanjie; Adeyemo, Adebowale; Panguluri, Ramesh K.; Chen, Weidong; Amoah, Albert; Opoku, Victoria; Acheampong, Joseph; Agyenim-Boateng, Kofi; Eghan, Benjamin; Nyantaki, Awuah; Oli, Johnnie; Okafor, Godfrey; Ofoegbu, Esther N; Osotimehin, Babatunde; Abbiyesuku, F M; Johnson, Thomas; Fasanmade, O.A; Rufus, Theresa; Furbert-Harris, Paulette; Daniel, H.; Berg, Kate; Collins, Francis S.; Dunston, Georgia M.; Rotimi, Charles N.

doi:10.1016/j.annepidem.2004.05.014

Cited by 32 publications

(29 citation statements)

References 25 publications

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“…In addition, the risk associated with this gene also differs between ethnically diverse populations from West Africa. Specifically, a CAPN10 haplotype defined by known risk polymorphisms was associated with T2DM in populations from Nigeria, but not in distinct populations from Ghana (31). Further study in a larger set of Africans will be needed to resolve this discrepancy.…”

Section: Type 2 Diabetes Mellitusmentioning

confidence: 92%

African Genetic Diversity: Implications for Human Demographic History, Modern Human Origins, and Complex Disease Mapping

Campbell

Tishkoff

2008

Annu. Rev. Genom. Hum. Genet.

680

573

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Comparative studies of ethnically diverse human populations, particularly in Africa, are important for reconstructing human evolutionary history and for understanding the genetic basis of phenotypic adaptation and complex disease. African populations are characterized by greater levels of genetic diversity, extensive population substructure, and less linkage disequilibrium (LD) among loci compared to non-African populations. Africans also possess a number of genetic adaptations that have evolved in response to diverse climates and diets, as well as exposure to infectious disease. This review summarizes patterns and the evolutionary origins of genetic diversity present in African populations, as well as their implications for the mapping of complex traits, including disease susceptibility.

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Section: Type 2 Diabetes Mellitusmentioning

confidence: 92%

African Genetic Diversity: Implications for Human Demographic History, Modern Human Origins, and Complex Disease Mapping

Campbell

Tishkoff

2008

Annu. Rev. Genom. Hum. Genet.

680

573

View full text Add to dashboard Cite

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“…They also suggested that polymorphisms in the Calpain-10 gene, not individually but in combination, account for the increased risk of T2DM. Chen et al [17] reported that subjects who had 221 haplotype of SNP-43, -56 and -63 showed increased risk of T2DM, whereas allele and genotype frequen- cies of these SNPs did not differ between T2DM and controls in Nigerians. In a study evaluating SNP-43, -19 and -63 haplotype combinations, SNP-43 A allele was found to be associated with the risk of T2DM, and 121/221 haplotype combination was associated with T2DM, in a Tunisian population [18].…”

Section: Prace Oryginalnementioning

confidence: 99%

Wpływ polimorfizmu genu kalpainy-10 na rozwój cukrzycy typu 2 w populacji tureckiej

Arslan¹,

Açık²,

Gunaltili³

et al. 2014

Endokrynologia Polska

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Introduction: The variations in the Calpain-10 gene have been suggested to be related to susceptibility to type 2 diabetes mellitus (T2DM) in different populations. In this study, we investigated the relationship between single nucleotide polymorphism (SNP)-19, -44 and -63 in the Calpain-10 gene and the development of T2DM in a Turkish population. Material and methods: A total of 211 subjects were recruited: 118 patients with a diagnosis of T2DM and 93 unrelated healthy subjects. Results: There were no significant differences in the genotype and allele distribution of SNPs studied between the patients with T2DM and controls (p > 0.05), whereas the frequencies of 121 haplotype and 122/121 haplotype combination were found to be higher in patients with T2DM than in controls (p < 0.05). No association was observed between the variations in the Calpain-10 gene and glycaemic control and lipid parameters (p > 0.05). The SNP-19 insertion/insertion was significantly related to increased body mass index (BMI) in male diabetic patients (p < 0.05).

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“…CAPN10 is comprised of 15 exons spanning 31 kb of genomic sequence and encodes a 672-amino-acid intracellular protease. The allele combination of CAPN10 , is reported to be associated with increased risk of T2DM in many populations (Horikawa et al 2000;Cassell et al 2002;Elbein et al 2002;Lynn et al 2002;Malecki et al 2002;Iwasaki et al 2005), although this is somewhat controversial (Tsai et al 2001;Daimon et al 2002;Fingerlin et al 2002;Chen et al 2005;Wu et al 2005). The 112/121 diplotype of CAPN10 is associated with a 3-fold increase in the risk of contracting T2DM in Mexican-Americans and in Northern European populations (Horikawa et al 2000).…”

Section: Introductionmentioning

confidence: 99%

A novel 111/121 diplotype in the Calpain-10 gene is associated with type 2 diabetes

et al. 2006

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Genetic variations in the Calpain-10 gene, CAPN10, have been reported to be associated with the risk of type 2 diabetes mellitus (T2DM) in MexicanAmericans and Northern Europeans whereas these variations are not associated with T2DM in other populations. The aim of this study was to determine whether there is an association between specific CAPN10 diplotype and T2DM in the Korean population. Overall, 454 Korean patients with T2DM (male 230, female 224) and 236 non-diabetic controls (male 124, female 112) with no family history of diabetes were enrolled in this study. All the subjects were genotyped according to CAPN10 SNP-43, -19, and -63. The restriction fragment length polymorphism method was used for the three SNPs. There were eight estimated haplotype allelic variations. After adjusting for gender and age, the 111 haplotype was associated with a high risk of T2DM (P <0.0001). The 111/121 diplotype was associated with a high risk of T2DM (odds ratio =2.580, 95% confidence interval =1.602-4.155, P =0.001). The high-risk haplotype (112/121) in Mexican-Americans was not significant in our study population. In conclusion, we found that a novel 111/121 diplotype in Calpain-10 gene is associated with T2DM in the Korean population.

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Calpain-10 gene polymorphisms and type 2 diabetes in West Africans: the Africa America Diabetes Mellitus (AADM) Study

Cited by 32 publications

References 25 publications

African Genetic Diversity: Implications for Human Demographic History, Modern Human Origins, and Complex Disease Mapping

African Genetic Diversity: Implications for Human Demographic History, Modern Human Origins, and Complex Disease Mapping

Wpływ polimorfizmu genu kalpainy-10 na rozwój cukrzycy typu 2 w populacji tureckiej

A novel 111/121 diplotype in the Calpain-10 gene is associated with type 2 diabetes

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