Calretinin expression in odontogenic cysts and odontogenic tumors and the possible role of calretinin in pathogenesis of ameloblastoma

Rudraraju, Amrutha; Venigalla, Aparna; Babburi, Suresh; Soujanya, Pinnisetti; Subramanyam, RV; Lakshmi, K Roja

doi:10.4103/jomfp.jomfp_54_19

Cited by 11 publications

(13 citation statements)

References 22 publications

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“…There were 11 studies [10][11][12][13][14][15][16][17][18][19][20] from Asia, three from North America, [21][22][23] four from South America, [24][25][26][27] and one 28 from the Australian population. The age ranges in AB and AC were found to be 11-78 years 11,13,18,20,22,25,28 and 16-72 years, respectively.…”

Section: Study Characteristics Clinical Featuresmentioning

confidence: 99%

Differential Expression of Immunohistochemical Markers in Ameloblastoma & Ameloblastic Carcinoma: A Systematic Review and Meta-analysis of observational studies

Mishra,

Panda,

Mohanty

et al. 2024

F1000Res

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Background Differentiating between ameloblastoma (AB) and ameloblastic carcinoma (AC) is difficult, especially when AB has atypical cytological characteristics or an uncommon clinical history. This systematic review and meta-analysis aimed to elucidate the differential expression of immunohistochemical markers between AB and AC. Methods We conducted a thorough search of PUBMED and SCOPUS according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to identify cross-sectional studies that compared the expression of immunohistochemical markers in AB and AC. We used a random-effects model to analyze the risk ratios and their corresponding 95% confidence intervals (CIs). The quality of the included studies was assessed using the Newcastle-Ottawa scale. The Egger’s test was used to assess publication bias. Results In total, 301 articles were identified. After excluding irrelevant titles and abstracts, 86 articles were selected for full-text review. We categorized the 41 markers into proliferative and non-proliferative markers. Among non-proliferative markers, nuclear markers were differentially expressed in AB and AC. SOX2 was the only marker that significantly differentiated AB and AC, with an RR of -0.19 (CI 0.10-0.36, I2=0). Conclusion The current evidence suggests the significance of SOX2 in differentiating between AB and AC, warranting prospective confirmation in well-defined extensive studies. We highlight the paucity of high-quality replicated studies of other markers in this field. Collaborative efforts with standardized techniques are necessary to generate clinically useful immunohistochemical markers.

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Section: Study Characteristics Clinical Featuresmentioning

confidence: 99%

Differential Expression of Immunohistochemical Markers in Ameloblastoma & Ameloblastic Carcinoma: A Systematic Review and Meta-analysis of observational studies

Mishra,

Panda,

Mohanty

et al. 2024

F1000Res

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“…El quiste dentígero es un quiste odontógenico muy común y se caracteriza por estar asociado a la corona de un diente no erupcionado (24) , es más prevalente en el sexo femenino y en personas mayores a 20 años (25) ; sin embargo, puede presentarse asociado a dientes supernumerarios en niños o adolescentes (26) . En este reporte se presenta el caso de un paciente masculino de catorce años de edad con un canino mandibular incluido, asociado a quiste dentígero.…”

Section: Discusionunclassified

“…A pesar de las diferentes técnicas de abordaje quirúrgico para esta patología, optamos por la enucleación total de la lesión a razón de que varios autores coinciden que los quistes foliculares pueden transformarse en tumores (26) , además en el presente caso se expone una cortical vestibular destruida por ende el desplazamiento mucoperiostal está indicado ya que esta cortical no se mantendrá después del tratamiento.…”

Section: Seunclassified

Manejo de quiste dentígero mandibular más fijación ósea rígida. Presentación de un caso

Sarasty

Medina

Cavadia

et al. 2020

Kiru

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El objetivo de este reporte es mostrar el manejo de un paciente con diagnóstico de quiste dentígero mandibular. Se presenta el caso de un paciente de sexo masculino de 14 años de edad, sin antecedentes mórbidos de importancia a la clínica odontológica SERODU, en la tomografía axial computarizada se evidenció una sombra radiolúcida entre las piezas dentales 42,44 y 45 con la pieza Nº43 incluida en la sínfisis de la región mandibular, posición horizontal de la pieza dental, la corona hacia distal y su raíz hacia medial con formación completa. A nivel de la corona se puede observar una sombra radiolúcida bien definida con un halo radiopaco, compatible con un quiste dentígero. Por lo que se decidió llevar acabo el tratamiento endodóntico en las piezas dentales 43, 44,45, posteriormente se realizó la enucleación de la lesión, exéresis de la pieza dentaria, curetaje y fijación óseo rígida, para evitar complicaciones patológicas de estructuras adyacentes como fractura mandibular por la dimensión de la lesión. Se obtuvo un diagnóstico histopatológico de quiste dentígero. Al control de treinta días, se observó radiográficamente, una zona radiopaca compatible con regeneración ósea, con un halo radiolúcido de separación con el hueso basal original. La enucleación y la fijación ósea rígida, resultaron ser un tratamiento eficaz para eliminar dicha lesión que resultó ser benigna.

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“…6 On the other hand, calretinin can be observed in many normal and neoplastic tissues, as well as in odontogenic epithelium during odontogenesis. 8, 9 Lei and colleagues (2014) observed that calretinin showed variable 25% positivity in four ameloblastomas, in 66.7% of the three atypical ameloblastoma, and in 50% of the 10 ameloblastic carcinoma cases. 10 The authors also informed that staining was variable in density and labeled only a small portion of the neoplastic cells.…”

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confidence: 99%

Diagnosis, Treatment, and Total Rehabilitation of a Secondary Type Ameloblastic Carcinoma

et al. 2022

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Ameloblastic carcinoma (AC) is an uncommon malignant odontogenic tumor, with about 200 cases published in the literature. Here, we report a case of AC occurring in the maxilla - at the same anatomical location of an ameloblastoma 8 years earlier. A 23-year-old woman with maxillary swelling of 6-month duration was referred to our service. Extraoral examination revealed a swelling over the right side of the face, lifting her lip and nose. Intraorally, a firm, reddish, nodular swelling involving the right maxilla was observed. Computed tomography showed a hypodense image invading the right maxilla, maxillary sinus, and nasal fossa. An incisional biopsy was performed, followed by histopathologic examination and an immunohistochemical panel, which led to the diagnosis of AC. The lesion was treated with partial maxillectomy followed by immediate rehabilitation. Neither local recurrence of the tumor nor distant metastasis was observed during a 4-year follow-up. AC is a highly malignant lesion which requires aggressive therapy. Its diagnosis should be based on combined clinical, imaging, and pathological manifestations in order to improve diagnostic accuracy.

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Calretinin expression in odontogenic cysts and odontogenic tumors and the possible role of calretinin in pathogenesis of ameloblastoma

Cited by 11 publications

References 22 publications

Differential Expression of Immunohistochemical Markers in Ameloblastoma & Ameloblastic Carcinoma: A Systematic Review and Meta-analysis of observational studies

Differential Expression of Immunohistochemical Markers in Ameloblastoma & Ameloblastic Carcinoma: A Systematic Review and Meta-analysis of observational studies

Manejo de quiste dentígero mandibular más fijación ósea rígida. Presentación de un caso

Diagnosis, Treatment, and Total Rehabilitation of a Secondary Type Ameloblastic Carcinoma

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