Cambodian Phellinus linteus Inhibits Experimental Metastasis of Melanoma Cells in Mice via Regulation of Urokinase Type Plasminogen Activator

Lee, Hyo‐Jung; Lee, Hyo‐Jeong; Lim, Eu-Soo; Ahn, Kwang‐Soon; Shim, Beom-Sang; Kim, Hyung-Min; Gong, Soo-Ja; Kim, Daekeun; Kim, Sung Hoon

doi:10.1248/bpb.28.27

Cited by 47 publications

(39 citation statements)

References 22 publications

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“…Our data are in agreement with the study by Lee et al (2005) demonstrating the inhibition of adhesion, invasion and expression of uPA in mouse melanoma cells. Furthermore, our data suggest the mechanism of inhibition of invasiveness by PL.…”

Section: Discussionsupporting

confidence: 93%

“…On the other hand, PL demonstrated antiinflammatory effects in lipopolysaccharide-stimulated macrophages (Kim et al, 2006). The direct anticancer effect of PL has been demonstrated by the inhibition of invasive melanoma B16BL6 cells through the downregulation of mRNA level of urokinaseplasminogen activator (uPA), and by the inhibition of pulmonary metastasis in mice (Lee et al, 2005). Phellinus linteus suppressed proliferation by the inhibition of cyclin-dependent kinases cdk2, 4 and 6, and induced apoptosis through the activation of caspase 3 in lung cancer cells and apoptosis of prostate cancer cells (Collins et al, 2006;Zhu et al, 2007).…”

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confidence: 99%

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Phellinus linteus suppresses growth, angiogenesis and invasive behaviour of breast cancer cells through the inhibition of AKT signalling

et al. 2008

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The antitumour activity of a medicinal mushroom Phellinus linteus (PL), through the stimulation of immune system or the induction of apoptosis, has been recently described. However, the molecular mechanisms responsible for the inhibition of invasive behaviour of cancer cells remain to be addressed. In the present study, we demonstrate that PL inhibits proliferation (anchorage-dependent growth) as well as colony formation (anchorage-independent growth) of highly invasive human breast cancer cells. The growth inhibition of MDA-MB-231 cells is mediated by the cell cycle arrest at S phase through the upregulation of p27Kip1 expression. Phellinus linteus also suppressed invasive behaviour of MDA-MB-231 cells by the inhibition of cell adhesion, cell migration and cell invasion through the suppression of secretion of urokinase-plasminogen activator from breast cancer cells. In addition, PL markedly inhibited the early event in angiogenesis, capillary morphogenesis of the human aortic endothelial cells, through the downregulation of secretion of vascular endothelial growth factor from MDA-MB-231 cells. These effects are mediated by the inhibition of serinethreonine kinase AKT signalling, because PL suppressed phosphorylation of AKT at Thr 308 and Ser 473 in breast cancer cells. Taken together, our study suggests potential therapeutic effect of PL against invasive breast cancer.

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Section: Discussionsupporting

confidence: 93%

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confidence: 99%

Phellinus linteus suppresses growth, angiogenesis and invasive behaviour of breast cancer cells through the inhibition of AKT signalling

et al. 2008

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“…However, this effect only shown in lung in H22 experiments. These results are similar to that reported by Lee, Kang and their partners (Lee et al, 2005;Kang et al, 2003), so it is speculated that the PI's inhibition effect will be stronger on more serious cancer.…”

Section: Discussionsupporting

confidence: 90%

Different Immunology Mechanisms of Phellinus igniarius in Inhibiting Growth of Liver Cancer and Melanoma Cells

Zhou

Jiang²,

Wang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…In addition, PL increased macrophage NO production. Lee et al [26] demonstrated that PL might inhibit metastasis at least in part through the regulation of urokinase type plasminogen activator (uPA) associated with tumor cell-induced platelet aggregation. Although PL showed no cytotoxicity against invasive melanoma cells (B16BL6 cells), PL inhibited platelet aggregation induced by B16BL6 cells.…”

Section: Inhibition Of Metastasismentioning

confidence: 99%

Anticancer Effect of Phellinus linteus; Potential Clinical Application in Treating Pancreatic Ductal Adenocarcinoma

Kang¹,

Han²,

Hwang³

et al. 2013

J Carcinogene Mutagene

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Pancreatic cancer (ductal adenocarcinoma) is one of the most lethal malignancies in gastrointestinal system. Till now, only margin-negative pancreatectomy is known to be the best treatment option for long-term survival. However, the resection rate is reported to be less than 20%. Even in cases of curative resection, most patients generally experience disease recurrence and ultimately die of metastatic disease. Therefore, surgery alone is not enough and adjuvant systemic chemotherapy should be considered for proper management of pancreatic cancer. But, its related toxicity and insufficient oncologic effect requires development of less toxic and more effective alternative treatments for pancreatic cancer. Phellinus linteus (PL), a basidiomycete, is a species of mushroom, which is reported to have the most potent antitumor effect of the basidiomycetes. Recently, there are accumulating researches discovering biologic mechanisms of PL in antitumor effect. However, very few studies were done in pancreatic cancer treatment. In this review, literatures demonstrating the anticancer effects of PL were summarized and some encouraging research data suggesting mushroom component can be alternative approach even in treating pancreatic cancer were reviewed, including our preliminary data suggesting the potential clinical application of PL in treating pancreatic cancer.

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Cambodian Phellinus linteus Inhibits Experimental Metastasis of Melanoma Cells in Mice via Regulation of Urokinase Type Plasminogen Activator

Cited by 47 publications

References 22 publications

Phellinus linteus suppresses growth, angiogenesis and invasive behaviour of breast cancer cells through the inhibition of AKT signalling

Phellinus linteus suppresses growth, angiogenesis and invasive behaviour of breast cancer cells through the inhibition of AKT signalling

Different Immunology Mechanisms of Phellinus igniarius in Inhibiting Growth of Liver Cancer and Melanoma Cells

Anticancer Effect of Phellinus linteus; Potential Clinical Application in Treating Pancreatic Ductal Adenocarcinoma

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