2024
DOI: 10.1002/eji.202350773
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Camelid‐derived Tcell engagers harnessing human γδ T cells as promising antitumor immunotherapeutic agents

Lola Boutin,
Clément Barjon,
Morgane Chauvet
et al.

Abstract: In the last decade, there has been a surge in developing immunotherapies to enhance the immune system's ability to eliminate tumor cells. Bispecific antibodies known as T cell engagers (TCEs) present an attractive strategy in this pursuit. TCEs aim to guide cytotoxic T cells toward tumor cells, thereby inducing a strong activation and subsequent tumor cell lysis. In this study, we investigated the activity of different TCEs on both conventional alpha‐beta (αβ) T cells and unconventional gamma delta (γδ) T cell… Show more

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