Campylobacter concisus

Abstract

Campylobacter concisus has been described as the etiological agent of periodontal disease, inflammatory bowel diseases, and enterocolitis. It is also detected in healthy individuals. There are differences between strains in healthy individuals and affected ones by production of two exototoxins. In this mini review authors discuss major facts about cultivation, isolation, virulence and immune response to C. concisus.

Dysbiosis of Oral Microbiota and Metabolite Profiles Associated with Type 2 Diabetes Mellitus

“… N , n -dimethylarginine is an endogenous inhibitor of endothelial nitric oxide (NO) synthase ( 39 ), and NO content is reduced in periodontal disease ( 40 ). Campylobacter concisus is an emerging bacterial pathogen that may play a role in the development of oral inflammatory conditions such as periodontal disease ( 41 , 42 ), which may also be due to its inhibition of NO production during periodontal inflammation. These related data suggest that patients with type 2 diabetes have significant taxonomic disturbances in the saliva and supragingival plaque microflora, which may also lead to significant changes in related metabolic profiles.…”

Biodiversity Dynamics of Campylobacter Species in Chicken Tissues in Rural Households in Region Epirus, Greece

“…jejuni and C. coli are perhaps the most investigated Campylobacter species due to their impact on public health, but other species of this genus are also detrimental to human health causing serious and-occasionally-life-threatening disease. To mention a few, C. concisus has been linked to cases of enterocolitis, periodontal disease, and inflammatory bowel disease (IBD) [17], C. fetus has been described as the causative agent of cervical osteomyelitis [18], and bacteremia [19], while C. upsaliensis and C. ureolyticus have been isolated from patients undergoing periodontitis, IBD, and gastroenteritis [20]. The list is much longer of course and still growing, raising alarm with respect to the genus Campylobacter.…”