Campylobacter Concisus and Its Effect on the Expression of CDX1 and COX2

Namin, Behrooz Mozaffari; Dallal, Mohammad Mehdi Soltan

doi:10.31557/apjcp.2018.19.11.3211

Cited by 5 publications

(2 citation statements)

References 35 publications

(32 reference statements)

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“…An in vitro study indicated the relationship between esophageal colonization by C. concisus and the epithelial production of TNFα and IL-18, known to induce both an innate and adaptive immune response and to increase CDX1 and COX-2 expression. In turn, this escalates the rate of colonization and chronic inflammation, which has been shown to lead to disease progression in GERD, Barrett’s esophagus and EC [ 33 , 43 ].…”

Section: Discussionmentioning

confidence: 99%

Association between infection with Campylobacter species, poor oral health and environmental risk factors on esophageal cancer: a hospital-based case–control study in Thailand

et al. 2021

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Background Previous studies have shown the association between Campylobacter species infection and that environmental factors, poor oral hygiene in particular, are linked to an increased risk of esophageal cancer (EC). However, no study has reported on these factors in Thailand. Thus, this study’s objective was to evaluate the impact of the relationship between Campylobacter infection and environmental factors on EC incidence in the population of Thailand. Methods Data from a case–control study were collected from 105 newly diagnosed EC cases and 105 controls recruited from 2007 to 2017. Infection with Campylobacter spp. was detected in the formalin-fixed paraffin-embedded (FFPE) tissue of EC taken from gastroesophageal biopsy specimens obtained from the participants, and evaluated using TaqMan® real-time PCR. Multivariable logistic regression was performed to calculate the odds ratios (ORs) and perform data analysis. Results Smoking, alcohol use, a family history of cancer, history of gastroesophageal reflux disease, poor oral hygiene and Campylobacter spp. infection were shown to be significant risk factors for EC (p < 0.05). The combination of poor oral hygiene and infection with Campylobacter spp. constituted significant risk for EC (p < 0.001). In addition, the risk of EC in subjects co-infected with C. rectus and C. concisus that practiced poor oral hygiene was even higher and was significant (ORadj = 4.7; 95% CI 2.41–9.98; p = 0.003). Conclusions In Thailand, the major risk factors for EC are smoking status, alcohol drinking, family history of cancer, GERD, poor oral hygiene and Campylobacter spp. infection. This study found Campylobacter spp. prevalence to be associated with EC and appears to be enhanced by poor oral hygiene, suggesting that a combination of poor oral hygiene and Campylobacter species infection may together act as an important etiological risk factor for EC.

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Section: Discussionmentioning

confidence: 99%

Association between infection with Campylobacter species, poor oral health and environmental risk factors on esophageal cancer: a hospital-based case–control study in Thailand

et al. 2021

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show abstract

“…An in vitro study indicated the relationship between esophageal colonization by C. concisus and the epithelial production of TNFα and IL-18, known to induce both an innate and adaptive immune response and to increase CDX1 and COX-2 expression. In turn, this escalates the rate of colonization and chronic in ammation, which has been shown to lead to disease progression in GERD, Barrett's esophagus and EC [43,44].…”

Section: Discussionmentioning

confidence: 99%

Association Between Infection With Campylobacter Species and the Risk of Esophageal Cancer: A Hospital-Based Case–Control Study in Thailand

Poosari

Nutravong

Sa-Ngiamwibool

et al. 2021

Preprint

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Background Previous studies have shown the association between Campylobacter species infection and environmental factors, poor oral hygiene in particular, is linked to an increased risk of esophageal cancer (EC). However, no study has reported on these factors in Thai. Thus, this study objective was to evaluate the impact of the relationship between Campylobacter infection and environmental factors on EC incidence in the population Thailand. Methods Data from a case–control study were collected from 105 newly diagnosed EC cases and 105 controls recruited from 2007 to 2017. Infection with Campylobacter spp. was detected in the Formalin-fixed paraffin-embedded (FFPE) tissue of EC taken from gastroesophageal biopsy specimens obtained from the participants and evaluated using a TaqMan® real-time PCR. Multivariable logistic regression was performed to calculate the odds ratios (ORs) and perform data analysis. Results Smoking, alcohol use, a family history of cancer, history of gastroesophageal reflux disease, poor oral hygiene and Campylobacter spp. infection were shown to be significant risk factors for EC (p < 0.05). The combination of poor oral hygiene and infection with Campylobacter spp. constituted significant risk for EC (p < 0.001). In addition, the risk of EC in subjects co-infected with C. rectus and C. concisus practiced poor oral hygiene was even higher and was significant (ORadj = 4.7, 95%CI: 2.41–9.98, p = 0.003). Conclusions In Thailand, poor oral hygiene and infection with Campylobacter spp. was associated with an increased risk of EC.

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Oncogenic potential of Campylobacter infection in the gastrointestinal tract: narrative review

Kato,

Minkevitch,

Sun

2023

Scandinavian Journal of Gastroenterology

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Campylobacter Concisus and Its Effect on the Expression of CDX1 and COX2

Cited by 5 publications

References 35 publications

Association between infection with Campylobacter species, poor oral health and environmental risk factors on esophageal cancer: a hospital-based case–control study in Thailand

Association between infection with Campylobacter species, poor oral health and environmental risk factors on esophageal cancer: a hospital-based case–control study in Thailand

Association Between Infection With Campylobacter Species and the Risk of Esophageal Cancer: A Hospital-Based Case–Control Study in Thailand

Oncogenic potential of Campylobacter infection in the gastrointestinal tract: narrative review

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