Can absolute basophilia distinguish e1a2 BCR-ABL1 chronic myeloid leukemia from chronic myelomonocytic leukemia?

Case report: Co-existing chronic myeloid leukemia and chronic myelomonocytic leukemia–A clinically important but challenging scenario

“…CML has no morphologic dysplasia and has BCR/ABL1 rearrangement, while CMML shows morphologic dysplasia and no BCR/ABL rearrangement. In one study, 54% of patients with peripheral blood basophils >0.40 × 10 9 /L were CML, while CMML only accounted for 4.2% of cases with that level of basophilia [5] . Therefore, a high basophil count might hint at CML instead of CMML.…”

“…Tyrosine kinase inhibitor (TKI, including first-generation imatinib; second-generation nilotinib, dasatinib, and bosutinib; and third-generation ponatinib) has been the mainstream therapy for the past two decades [1] , [2] , [3] , [4] . The 10-year overall survival has exceeded 80% for patients in the chronic phase CML [ 5 , 6 ].…”

“…A subset of CMML (15%) has the potential to progress into acute myeloid leukemia within 3 to 5 years [7] . The diagnosis of CMML requires a FISH or PCR study for BCR/ABL to exclude CML [5] and other myeloid neoplasms based on the World Health Organization (WHO) classification. Of note, some cases of CML, especially those with the BCR/ABL1 p190 variant, often resemble CMML due to the associated marked monocytosis [8] .…”

Differential diagnoses and the mutational landscape of myelodysplastic/myeloproliferative neoplasm with neutrophilia: A case report

“…granulocytes is very atypical (7,8). Second, the erythropoietic precursor cells accounted for between 27-31% of the hematopoiesis, as assessed by three different investigators.…”