Can Adiponectin be a biomarker for Ethnic heterogeneity in Diabetes Mellitus?

Elshaari, Farag A.; Sheriff, Dhastagir Sultan; Alshaari, A A; OmerSheriff, S.

doi:10.5772/59119

Cited by 3 publications

(3 citation statements)

References 41 publications

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“…However, such diagnostic tests should be highly specific and sensitive. [9,71] Hence, the overall primary requirements and benefits of NBS program are summarized in Figure 2. Moreover, overall usage of each technique in NBS, advantages, and disadvantages [57] are listed in Table 2 with more detail.…”

Section: Requirements and Benefits To Establish A Nbs Programmentioning

confidence: 99%

Need and Challenges in Establishing Newborn Screening Programs for Inherited Metabolic Disorders in Developing Countries

et al. 2023

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Even in this post genomic era, no national level newborn screening (NBS) programs for inborn errors of metabolism (IEMs) are yet available in several developing countries including Pakistan. Through NBS, various IEMs can be screened using minute quantities of biofluids. Targeted metabolomics and genomic techniques are the main approaches used for NBS. However, lack of technical expertise and such high-end "omics" based analytical facilities, and meager funding for healthcare in developing countries are the major reasons for unavailability of NBS programs. As it is reflected by only a handful reports about IEMs from Pakistan with population of ≈220 million and consanguinity rate of about 70%, which suggests an unmet need for an NBS program owing to reasonably high prevalence of inherited diseases. Around 200 IEMs are potentially treatable if diagnosed at an earlier stage through biochemical marker and genetic screening, so such patients can get benefit from the NBS program. This overview will help to persuade the stakeholders to setup NBS programs in developing countries including Pakistan, due to multitude of benefits for IEMs; timely diagnosis and early treatment can help the patients to live a nearly healthy life, reduced suffering of the family and minimal burden on society or national healthcare system.

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Section: Requirements and Benefits To Establish A Nbs Programmentioning

confidence: 99%

Need and Challenges in Establishing Newborn Screening Programs for Inherited Metabolic Disorders in Developing Countries

et al. 2023

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“…As an example, Figure 7a shows a waveguide (panel i) fabricated using a combination of bottom-up/top-down processes; the device is strain tuned and was demonstrated when integrated with a quantum emitter and a planar integrated optical resonator consisting of a silicon nitride ring resonator fabricated on a piezoelectric substrate (panel ii). The tunability of the devices was tested by applying a voltage to the piezoelectric substrate while the quantum dot emission collected through the waveguide was recorded with the focusing optical fiber (panel iii) [137,138] . Ideally, an adiabatic coupling between the plasmon polaritons into a dielectric waveguide enables an efficient collection and simultaneously a significant enhancement of the sensitivity; the two conditions have been implemented in the photonic cavity like a whispering gallery mode that integers plasmonic structures in an opportune architecture for achieving the enhancement [139] [140] .…”

Section: Quantum Plasmonic Microsystem Biosensorsmentioning

confidence: 99%

Trends of Biosensing: Plasmonics through Miniaturization and Quantum Sensing

Simone

2023

Critical Reviews in Analytical Chemistry

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Despite being extremely old concepts, plasmonics and surface plasmon resonance-based biosensors have been increasingly popular in the recent two decades due to the growing interest in nanooptics and are now of significant significance in regards to applications associated with human health. Plasmonics used in health surveillance systems have a high sensitivity and meets the standards for sensitivity, selectivity, and detection limit. In addition, integration into microsystems and point-of-care devices has enabled significant levels of sensitivity and limit of detection to be achieved. All of this has encouraged the expansion of the fields of study and market niches devoted to the creation of quick and incredibly sensitive label-free detection. The trend is reflected in the development of wearable plasmonic sensors as well as point-of-care applications for widespread applications, demonstrating the potential impact of the new generation of plasmonic biosensors on human well-being through the concepts of personalized medicine and global health.In this context, the aim here is to discuss the potential, limitations, and opportunities for improvement that have arisen as a result of the integration of plasmonics into microsystems and lab-on-chip over the past five years. Recent applications of plasmonic biosensors in microsystems and their sensor performance are analyzed. The final discussion focuses on the integration of microfluidics and lab-on-a-chip with quantum plasmonics technology as a promising solution for chemical and biological sensing applications. Aiming to overcome the limits given by quantum fluctuations and noise, research in the field of quantum plasmonic sensing for biological applications has flourished over the past decade. The significant advances in nanophotonics, plasmonics and microsystems used to create increasingly effective biosensors would continue to benefit this field if harnessed properly.

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“…Jung et al [25] reported a significant relationship between ALR and the presence of MetS and the number of metabolic components in the population. A recent study also established that the ALR was a better marker for the assessment of acute metabolic stress [26]. LAR was served as a sensitive marker for the early detection of MetS [27,28].…”

Section: Introductionmentioning

confidence: 96%

Evaluation of serum adipokines with development of metabolic syndrome among industrial workers.

Jamalpur¹,

Adepu²,

Jakkam³

et al. 2020

Am J Prev Med Public Health

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Background: Most of the studies were reported serum adipokines with the presence of metabolic syndrome (MetS) in population-based studies. Objective: The present study assessed the levels of serum adipokines, i.e., leptin, adiponectin, leptin:adiponectin ratio (LAR), and adiponectin:leptin ratio (ALR), and the development of MetS among industrial workers. Methods: Eighty-eight workers were recruited in the study. MetS was diagnosed using the definition of the International Diabetes Federation. Serum leptin and adiponectin levels were done using enzyme linked immunosorbent assay methods. LAR and ALR values were calculated using the serum leptin and adiponectin. The data was analyzed using statistical package for the social sciences software. Mann-Whitney U test was used to find out the differences of adipokines among workers with or without MetS. Kruskal-Wallis test was used to find out the effect of the number of metabolic components (0, 1, 2, 3, and >4) on serum adipokines among workers. Results: 37.5% of workers had MetS. The levels of serum leptin (p < 0.01) and LAR (p < 0.01) were significantly increased and serum adiponectin (p = 0.104) and ALR (p < 0.01) were decreased in workers with the presence of MetS. The effect of the number of metabolic components was demonstrated a significant increase of serum leptin (p = 0.018) and LAR (p = 0.026) and significant decrease of ALR (p = 0.046). Conclusion:The levels of serum leptin and LAR were increased and adiponectin and ALR were decreased in workers with the presence of MetS and the number of metabolic components. The data of the present study support the role of adipokines and development of MetS. It could be used as specific indicators for the diagnosis and management of MetS.

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Can Adiponectin be a biomarker for Ethnic heterogeneity in Diabetes Mellitus?

Abstract: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported.

Cited by 3 publications

References 41 publications

Need and Challenges in Establishing Newborn Screening Programs for Inherited Metabolic Disorders in Developing Countries

Need and Challenges in Establishing Newborn Screening Programs for Inherited Metabolic Disorders in Developing Countries

Trends of Biosensing: Plasmonics through Miniaturization and Quantum Sensing

Evaluation of serum adipokines with development of metabolic syndrome among industrial workers.

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