Can bone wax cause cholesterol granuloma in the petrous apex? A case report

Letter: Risk of Bone Wax Migration During Retrosigmoid Craniotomy for Microvascular Decompression: Case-Control Study

“…Several histologic reports described foreign body reactions, granuloma formation, fibrosis, and/or chronic inflammation after application of bone wax in neurosurgical procedures. [2][3][4][5][6][7][8][9] Figure illustrates foreign body reactions to bone wax after removal in secondary surgery.…”

“…[13][14][15] Furthermore, the literature is replete with reports of rare but serious clinical complications associated with bone wax usage. These include paraplegia, 16 iatrogenic quadriplegia, 17 ptosis and diplopia, 18 venous sinus thrombosis, 5,19 skull osteohypertrophy, 3 peripheral facial palsy with trigeminal neuropathy, 4 elevated intraorbital and intraocular pressure, 20 swelling around the eye, 6,20 wound extrusion, 5 and speech and orientation deficits 21 because of bone wax deployment.…”