Can EGCG Reduce Abdominal Fat in Obese Subjects?

Hill, Alison M.; Coates, Alison; Buckley, Jonathan D.; Ross, Robert; Thielecke, Frank; Howe, Peter R. C.

doi:10.1080/07315724.2007.10719628

Cited by 123 publications

(126 citation statements)

References 37 publications

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“…To the best of our knowledge, only 2 RCTs (27, 36) have so far examined the effects of green tea catechins on lipids in postmenopausal women. Hill et al (27) did not observe any changes in lipids after the ingestion of 150 mg 2 n = 198 and 189 in the GTE and placebo groups, respectively, for the 12-mo time point. 3 P values for the interaction between treatment and baseline TC category were derived from a mixed-effects repeated-measures ANOVA with adjustment for age and BMI.…”

Section: Discussionmentioning

confidence: 99%

Effects of green tea catechin extract on serum lipids in postmenopausal women: a randomized, placebo-controlled clinical trial

Samavat

Newman

Wang

et al. 2016

The American Journal of Clinical Nutrition

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Background: Green tea has been suggested to improve cardiovascular disease risk factors, including circulating lipid variables. However, current evidence is predominantly based on small, short-term randomized controlled trials conducted in diverse populations. Objective: The aim of this study was to examine the efficacy and impact of green tea extract (GTE) supplementation high in epigallocatechin gallate (EGCG) on blood lipids in healthy postmenopausal women. Design: This was an ancillary study of a double-blind, randomized, placebo-controlled, parallel-arm trial investigating the effects of a GTE supplement containing 1315 mg catechins (843 mg EGCG) on biomarkers of breast cancer risk. Participants were randomly assigned to receive GTE (n = 538) or placebo (n = 537) and were stratified by catechol-O-methyltransferase (COMT) genotype activity (high COMT compared with low or intermediate COMT genotype activity). They consumed either 4 GTE or identical placebo capsules daily for 12 mo. A total of 936 women completed this substudy. Circulating lipid panels including total cholesterol (TC), HDL cholesterol, and triglycerides were measured at baseline and at months 6 and 12. Results: Compared with placebo, 1-y supplementation with GTE capsules resulted in a significant reduction in circulating TC (22.1% compared with 0.7%; P = 0.0004), LDL cholesterol (24.1% compared with 0.9%; P , 0.0001) and non-HDL cholesterol (23.1% compared with 0.4%; P = 0.0032). There was no change in HDL-cholesterol concentration, but triglyceride concentrations increased by 3.6% in the GTE group, whereas they decreased by 2.5% in the placebo group (P = 0.046). A significant reduction in TC was observed only among women with high (i.e., $200 mg/dL) baseline TC concentrations (P-interaction = 0.01) who consumed GTE capsules. The effect of GTE on the increase in triglycerides was mainly observed among obese women and statin users (P-interaction = 0.06). Conclusion: Supplementation with GTE significantly reduced circulating TC and LDL-cholesterol concentrations, especially in those with elevated baseline TC concentrations. This trial was registered at clinicaltrials.gov as NCT00917735.Am J Clin Nutr 2016;104:1671-82.

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Section: Discussionmentioning

confidence: 99%

Effects of green tea catechin extract on serum lipids in postmenopausal women: a randomized, placebo-controlled clinical trial

Samavat

Newman

Wang

et al. 2016

The American Journal of Clinical Nutrition

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“…Experiments in rodent models demonstrated that catechins reduced dietary fat-induced weight gain and body fat mass (Hasegawa, Yamda, & Mori, 2003;Ikeda et al, 2005;Murase, Haramizu, Shimotoyodome, Nagasawa, & Tokimitsu, 2005;Murase, Haramizu, Shimotoyodome, & Tokimitsu, 2006;Murase, Nagasawa, Suzuki, Hase, & Tokimitsu, 2002;Wolfram et al, 2005). Randomized controlled trials conducted to assess the effects of catechins have yielded conflicting results (Hill et al, 2007;Hsu et al, 2008;Maki et al, 2009;Matsuyama, Tanaka, Kamimaki, Nagao, & Tokimitsu, 2008;Nagao et al,2007Nagao et al, , 2009Wang et al, 2009;Yoneda et al, 2009), which may be due to differences in experimental periods, sample sizes, participant selection, concentrations of tested beverages and actives (with or without the presence of caffeine), interventions of diet and exercise, among others. Under conditions of P180 min/week moderate intensity exercise, there was no difference in the percentage changes in visceral fat area between the catechin and control groups (Hill et al, 2007).…”

Section: Introductionmentioning

confidence: 93%

“…Randomized controlled trials conducted to assess the effects of catechins have yielded conflicting results (Hill et al, 2007;Hsu et al, 2008;Maki et al, 2009;Matsuyama, Tanaka, Kamimaki, Nagao, & Tokimitsu, 2008;Nagao et al,2007Nagao et al, , 2009Wang et al, 2009;Yoneda et al, 2009), which may be due to differences in experimental periods, sample sizes, participant selection, concentrations of tested beverages and actives (with or without the presence of caffeine), interventions of diet and exercise, among others. Under conditions of P180 min/week moderate intensity exercise, there was no difference in the percentage changes in visceral fat area between the catechin and control groups (Hill et al, 2007). However, percentage changes in total abdominal fat area and subcutaneous fat area were greater in the catechin group (Hill et al, 2007).…”

Section: Introductionmentioning

confidence: 96%

Effects of catechin-enriched green tea beverage on visceral fat loss in adults with a high proportion of visceral fat: A double-blind, placebo-controlled, randomized trial

Zhang

Yan

et al. 2012

Journal of Functional Foods

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Body fat mass Catechins Green tea Visceral fat Functional beverage A B S T R A C T The effects of catechin-enriched green tea on Chinese adults with a high proportion of abdominal visceral fat were evaluated. Subjects (118) were randomly assigned to consume daily a beverage containing 609.3 mg catechins and 68.7 mg caffeine or a control beverage for 12 weeks. Abdominal fat area, body weight and composition were measured at week 0,week 8, and week 12. One hundred and four subjects completed the trial. Average visceral fat area, body weight, and body fat were reduced significantly by catechin-enriched green tea treatment but these effects were not seen in the control group with per-protocol sets analysis. The decrease at week 12 in the visceral fat area in the catechin group was greater than that in the control group (P = 0.04). Thus, consumption of the catechin-enriched green tea beverage for 12 weeks induced visceral fat loss in Chinese adults with a high proportion of abdominal visceral fat.

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“…A rare study has investigated the effects of EGCG on weight in postmenopausal women [38]. We have shown here that EGCG significantly suppresses weight gain in mice after OVX.…”

Section: Discussionmentioning

confidence: 67%

(–)-Epigallocathechin-3-Gallate, an AMPK Activator, Decreases Ovariectomy-Induced Bone Loss by Suppression of Bone Resorption

et al. 2012

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Previously, we showed that AMP-activated protein kinase (AMPK) negatively regulates receptor activator of nuclear factor-κB ligand-induced osteoclast formation in vitro. The present study investigated the effect of (-)-epigallocathechin-3-gallate (EGCG), an AMPK activator, on ovariectomy (OVX)-induced bone loss in mice. Female mice subjected to OVX were administered EGCG for 8 weeks. We measured total-body bone mineral density (BMD) before and after the operation at an interval of 4 weeks. We performed micro-computed tomography (micro-CT) of the tibia and bone histomorphometric examination of the femur. Western blot analysis was additionally performed, to detect levels of the phosphorylated and total forms of AMPK-α in calvarial extracts. EGCG prevented OVX-induced body weight gain. The OVX control did not show a significant increase in BMD values at baseline and after treatment, unlike the sham control. EGCG attenuated OVX-induced bone loss. Micro-CT experiments revealed that EGCG induced a significant increase in trabecular bone volume and trabecular number and a decrease in trabecular spacing compared to the OVX control. Histomorphometric analyses further showed that EGCG suppressed osteoclast surface and number. Phosphorylated AMPK expression was significantly elevated in bone following EGCG treatment. Our findings collectively indicate that EGCG decreases OVX-induced bone loss via inhibition of osteoclasts.

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Can EGCG Reduce Abdominal Fat in Obese Subjects?

Abstract: Moderate consumption of EGCG can improve the health status of overweight individuals undergoing regular exercise by reducing HR and plasma glucose concentrations. Loss of body fat, however, may require a higher intake of EGCG, other catechins or addition of metabolic stimulants.

Cited by 123 publications

References 37 publications

Effects of green tea catechin extract on serum lipids in postmenopausal women: a randomized, placebo-controlled clinical trial

Effects of green tea catechin extract on serum lipids in postmenopausal women: a randomized, placebo-controlled clinical trial

Effects of catechin-enriched green tea beverage on visceral fat loss in adults with a high proportion of visceral fat: A double-blind, placebo-controlled, randomized trial

(–)-Epigallocathechin-3-Gallate, an AMPK Activator, Decreases Ovariectomy-Induced Bone Loss by Suppression of Bone Resorption

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