Can Estimated Intravaginal Ejaculatory Latency Time Be Used Interchangeably With Stopwatch-measured Intravaginal Ejaculatory Latency Time for the Diagnosis of Lifelong Premature Ejaculation?

Lee, Won Ki; Cho, Sung Tae; Lee, Yong Seong; Lee, Young Goo; Oh, Cheol Young; Yoo, Changhee; Cho, Jin Seon; Shin, Tae Young; Lee, Sang-Kon; Lee, Seong Ho; Ko, Kwang–Hoon; Yang, Dae Yul

doi:10.1016/j.urology.2014.09.036

Cited by 25 publications

(17 citation statements)

References 16 publications

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“…Interestingly, eIELT was not significantly different between" CGIC = 0″ and" CGIC≥1″ groups, suggesting that eIELT might be poorly estimated in the real-world setting. Lee et al [7] compared stopwatch-determined IELT and eIELT in healthy men and found that eIELT was overestimated by approximately 1 min.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, stopwatch-determined intravaginal ejaculation latency time (IELT) is the most common measure to diagnose and evaluate treatment efficacy in clinical trials, which is not appropriate in real world practice. In the clinical setting, stopwatch-determined IELT is substituted by selfestimated IELT, which is often overestimated by patients [7].…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of dapoxetine treatment in Chinese patients with premature ejaculation and possible factors affecting efficacy in the real-world practice

Peng

Fang

et al. 2020

BMC Urol

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Background: The treatment effect of dapoxetine in real-world practice is not well established. This study was to investigate the factors influencing efficacy of dapoxetine for the treatment of Premature ejaculation (PE) in the realworld setting. Methods: Altogether 154 patients were followed up between Jan 2015 and Dec 2015. The clinical global impression of change (CGIC), premature ejaculation profile (PEP), the estimated intravaginal ejaculation latency time (eIELT) and estimated number of intravaginal thrusts before ejaculation (NITBE) were collected. The clinical characteristics of patients with CGIC = 0 and CGIC≥1 were compared. Results: After 4 weeks treatment, an obvious improvement compared with the baseline was found regarding mean eIELT (2.4 ± 1.6 min vs 1.0 ± 0.7 min, P < 0.001) and mean NITBE (85.9 ± 61.9 times vs 37.4 ± 28.6 times, P < 0.001). The proportion of patients with a self-evaluation of at least "slightly better" and were categorized into "CGIC≥1" group was 70.1%. There were significant differences between patients in the "CGIC = 0" and "CGIC≥1" groups regarding mean NITBE (P = 0.010) and PEDT (P = 0.009) score at baseline. The adverse effects were acceptable. Conclusion: Dapoxetine was well-tolerated and improved the sexual satisfaction of patients with PE. The severity of PE based on PEDT and NITBE suggest that there could be an effectiveness change with dapoxetine use in realworld practice.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Efficacy of dapoxetine treatment in Chinese patients with premature ejaculation and possible factors affecting efficacy in the real-world practice

Peng

Fang

et al. 2020

BMC Urol

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“…vaginal or anal penetration)’. Estimated ejaculation latencies have been used previously as a fairly reliable indicator of stopwatch‐measured latencies (Lee et al., 2015; Rosen et al., 2007). Using similar phraseology, men were also asked to estimate TYPICAL and IDEAL ELTs for men (in general) during partnered sex, as well as a threshold ELT characteristic of men with PE (PE ELT).…”

Section: Methodsmentioning

confidence: 99%

Global perspectives on the three criteria for premature ejaculation: An observational study of ejaculatory latency, ejaculatory control and bother/distress

Côté-Léger¹,

Rowland

2020

Andrologia

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Criteria for premature ejaculation (PE) were established using Western‐based samples, yet these criteria are applied worldwide for its diagnosis. This study (a) determined whether men from various world regions differ/agree on their views of ejaculation latency (ELT) and their perceptions of ejaculatory control and bother/distress, the three criteria for PE, and (b) compared PE and non‐PE men across worldwide regions on these measures. 1,065 participants were recruited via social media to respond to a survey about men's typical, ideal and PE ELTs, about their own ELT, and about perceptions of ejaculatory control and bother/distress related to PE. Responses from men from four worldwide regions were compared to a reference group of North American/European men, and PE men were compared with non‐PE men across three world regions. Results showed that most world region groups showed similarity in ELT estimations. The Sub‐Saharan group focused more heavily on the importance of ejaculatory control. Both ELT and ejaculatory control differed between PE and non‐PE groups in all regions assessed. In conclusion, perceived ELTs and ejaculatory control show substantial consistency across world regions despite geo‐cultural variations and traditions. Such findings argue for the universality of the concepts of ELT, control and bother/distress related to PE.

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“…Fourth, the nomogram was not externally validated using independent cohorts from other institutions, which may limit the broad application of the nomogram. Fifth, the IELT used in our study was self-reported IELT, which may be overestimated 33 and susceptible to subjectivity.…”

Section: Discussionmentioning

confidence: 99%

An Internally Validated Nomogram for Predicting the Likelihood of Improvement of Clinical Global Impression in Patients with Lifelong Premature Ejaculation Treated with Dapoxetine

Hou

Gao

Zhang

et al. 2020

The Journal of Sexual Medicine

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Background: Although the introduction of dapoxetine has ushered in a new era in the treatment of premature ejaculation, many patients with lifelong premature ejaculation (LPE) exhibit an unimproved clinical global impression even after treatment with dapoxetine. Aim: To investigate independent predictors of the improvement of Clinical Global Impression (iCGI) in patients with LPE treated with dapoxetine and develop a nomogram to predict a patient's likelihood of achieving iCGI. Methods: Data of 243 patients with LPE diagnosed at Xijing Hospital (Xi'an, China) and Northwest Women's and Children's Hospital (Xi'an, China) from January 2019 to May 2020 were analyzed. Independent predictors of iCGI were identified, and a nomogram was developed using R software based on a multivariate logistic regression model. The predictive accuracy of the nomogram was measured using the area under the receiver operating characteristic curve. The nomogram was calibrated by comparing predictions with observations. Main Outcome Measures: The primary outcome was the patient-rated Clinical Global Impression of Change scale score after a 4-week course of dapoxetine treatment, which was collected via an online questionnaire. A Clinical Global Impression of Change score of !1 was defined as iCGI in this study. Results: Patients with LPE with at least a bachelor's degree, a self-reported intravaginal ejaculation latency time of >1 minute, and an International Index of Erectile Function question 5 score of !3 were independent factors associated with achieving iCGI, whereas a Premature Ejaculation Diagnostic Tool question 1 score of !2 was an independent factor negatively associated with achieving iCGI. The predictive accuracy of the nomogram, which was developed by integrating all variables with independent predictive significance, was 0.710 (95% confidence interval: 0.702e0.718). In addition, the calibration plot demonstrated excellent agreement between predictions and observations. Clinical Implications: If the predictive performance of our nomogram is further proven in multiple external validations, it can be used to select suitable patients for dapoxetine treatment, thereby reducing the number of patients discontinuing treatment. Strengths & Limitations: This study developed the first nomogram for predicting the likelihood of achieving iCGI in patients with LPE treated with dapoxetine. However, our nomogram was not externally validated using independent cohorts from other institutions. Conclusion: This study identified several independent predictors of iCGI in patients with LPE treated with dapoxetine. An effective nomogram was developed to predict their likelihood of achieving iCGI.

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Can Estimated Intravaginal Ejaculatory Latency Time Be Used Interchangeably With Stopwatch-measured Intravaginal Ejaculatory Latency Time for the Diagnosis of Lifelong Premature Ejaculation?

Cited by 25 publications

References 16 publications

Efficacy of dapoxetine treatment in Chinese patients with premature ejaculation and possible factors affecting efficacy in the real-world practice

Efficacy of dapoxetine treatment in Chinese patients with premature ejaculation and possible factors affecting efficacy in the real-world practice

Global perspectives on the three criteria for premature ejaculation: An observational study of ejaculatory latency, ejaculatory control and bother/distress

An Internally Validated Nomogram for Predicting the Likelihood of Improvement of Clinical Global Impression in Patients with Lifelong Premature Ejaculation Treated with Dapoxetine

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