Can Hematological Parameters be a Indicator Risk Factor in the Development of Retinopathy of Prematurity?

Abstract

Background Hematological parameters have been investigated as being indicative of increased inflammatory response in morbidity of very preterm infants. This study aims to determine whether the hematologic parameters and ratios of preterms can be an indicative risk factor for the development of retinopathy of prematurity (ROP). Materials-Methods This retrospective cohort study examined newborns born before 32 weeks. Twenty-three patients treated with the diagnosis of ROP were included in the patient group. The control group included 23 patients who did not have ROP (no-ROP). Medical records of eligible preterm infants were retrospectively reviewed. Hemogram samples obtained from all patients during the first 24 h of life and samples of their mothers obtained before delivery were evaluated. The hemogram parameters of white blood cell (WBC) count, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, lymphocyte/monocyte ratio, and platelet mass index were calculated. Results No difference was observed between the groups in terms of demographic data. In terms of hematological parameters, maternal WBC counts of ROP patients were significantly higher than those of no-ROP patients and WBC counts of ROP patients were significantly lower than those of no-ROP patients. Conclusions This study found that high WBC counts in mothers before delivery and/or low WBC counts in preterms during the first postnatal day were higher in developed ROP. These results could lead to the development of prospective studies to assess the real prognostic value of WBC in ROP.

Association of platelet deficiency with severe retinopathy of prematurity: a review

“…In the present review, studies that defined subjects with stage 2 ROP or less as cases were explicitly excluded, to avoid confusion when interpreting the results (Figure 1). However, the definition of cases still differed significantly among studies, including type I ROP, 15,18,20,22,24,27,28,33 AP-ROP, 19 or ROP requiring treatment, encompassing both type I and AP-ROP, 16,21,23,26,[29][30][31] or at least stage 3 ROP. 25,31,32 Likewise, the definition of controls differed largely, including infants without ROP, 24,25,[27][28][29][30]32,33 ROP up to stage 1, 15,18,20,22,23 ROP up to stage 2, 19,31 or infants with less severe ROP, presumably including up to stage 3 without plus disease, namely type II ROP, 16,26 or even infants with unspecified ROP stage.…”

“…However, the definition of cases still differed significantly among studies, including type I ROP, 15,18,20,22,24,27,28,33 AP-ROP, 19 or ROP requiring treatment, encompassing both type I and AP-ROP, 16,21,23,26,[29][30][31] or at least stage 3 ROP. 25,31,32 Likewise, the definition of controls differed largely, including infants without ROP, 24,25,[27][28][29][30]32,33 ROP up to stage 1, 15,18,20,22,23 ROP up to stage 2, 19,31 or infants with less severe ROP, presumably including up to stage 3 without plus disease, namely type II ROP, 16,26 or even infants with unspecified ROP stage. 21 All these variations may affect the difference in the severity of ROP between the studied groups and therefore may have an impact on the outcome of interest.…”

“…Ultimately, 19 primary studies fulfilled the eligibility criteria and were included in this review: 18 clinical studies and one study with both experimental and clinical sections. All the clinical studies were observational, of which one case series, 17 eight retrospective case-control studies with or without matching, 15,[18][19][20][21][22][23][24] eight retrospective cohort studies, 16,[25][26][27][28][29][30][31] and two prospective cohort studies. 32,33 If studies comprised three groups, 24,27,29,30,33 comparative data were only collected on cases with ROP requiring treatment and the group of infants without ROP.…”

“…Over the last decade, a number of primary, observational, cohort or case-control studies, were conducted to evaluate associations between platelet parameters and severe ROP. 15,16,[18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33]…”

The Relationship Between Platelet Lymphocyte Ratio and Neonatal Morbidities, Chorioamnionitis

“…Tam kan indeksleri ve ciddi ROP ilişkisinin incelendiği bir çalışmada ilk bakılan kan örneğinde düşük trombosit değerleri ciddi ROP ile ilişkili bulunmuş (23). Çelik ve arkadaşlarının benzer çalışmalarında ise maternal lökosit değerlerinin ROP üzerine etkisi bulunmazken, 32 hafta altı prematüre bebeklerinde postnatal ilk günde bakılan lökosit sayısının yüksek olması ROP için bir risk faktörü olarak bulunmuş (24). Biz de bu çalışmaya benzer olarak anne lökosit sayısı ile ROP arasında ilişki bulmazken, lazer gerektiren grubun lökosit sayısı anlamlı derecede yüksek bulduk.…”