Can hsCRP be the sole investigation for predicting the severity and outcome in women with pre-eclampsia presenting late in pregnancy?

Mishra, Neetu; Pradhan, Kumudini; Sahoo, GD; Rohilla, Manish; Meena, Manoj

doi:10.4103/tjog.tjog_66_18

Cited by 4 publications

(2 citation statements)

References 1 publication

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“…Raised CRP levels are considered as a biomarker of chronic systemic inflammation 13 . Several longitudinal and cross‐sectional studies in women with PE have reported high serum levels of CRP 10,14–19 . In contrast, others have reported similar levels in PE and controls 20–22 .…”

Section: Introductionmentioning

confidence: 99%

Longitudinal profile of high‐sensitivity C‐reactive protein in women with pre‐eclampsia

Dangat

Wadhwani

Randhir

et al. 2023

American J Rep Immunol

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Problem: C-reactive protein (CRP) is a marker for inflammation and its role as a possible biomarker for an early prediction of pre-eclampsia (PE) is unclear. The present study investigates the levels of high-sensitivity CRP (hs-CRP) longitudinally across pregnancy in women with PE and compares them to women without PE (non-PE). Method of Study: A total of 324 pregnant women [216 non-PE and 108 PE women]were included in this study. Maternal blood was taken at four different intervals (V1 = 11-14 weeks, V2 = 18-22 weeks, V3 = 26-28 weeks, and V4 = at delivery).Results: Maternal serum hs-CRP levels were higher at V1, V2, and V3 (p < .05 for all) in the PE group compared to the non-PE group. The hs-CRP levels were associated with maternal blood pressure throughout pregnancy. Maternal hs-CRP levels did not differ among early and late onset PE. Higher maternal hs-CRP levels were associated with the increased risk of PE in unadjusted model in early pregnancy. However, there was no significance after adjusting for confounding factors. Conclusions:Our findings suggest although the levels of hs-CRP were higher in PE in early pregnancy, they are not associated with an increased risk of PE.

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Section: Introductionmentioning

confidence: 99%

Longitudinal profile of high‐sensitivity C‐reactive protein in women with pre‐eclampsia

Dangat

Wadhwani

Randhir

et al. 2023

American J Rep Immunol

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“…Previous studies aiming to predict the risk of coronary and cerebrovascular disease in an apparently healthy population, much before their occurrence found an elevated level of CRP in the susceptible group [ 7 , 8 ]. The high-sensitivity C-reactive protein (hs-CRP) has been used by obstetricians to predict the outcome of pregnancies complicated by pre-eclampsia [ 9 ]. The traditional methods of CRP measurement are capable of measuring CRP in the ranges of 3–5 mg/L, which is useful for infections, but not if there is only a minute increase.…”

Section: Introductionmentioning

confidence: 99%

Can High-Sensitivity C-Reactive Protein Levels Predict Functional Outcome Following Epidural Steroid Injection in Patients with Lumbar Disc Disease?

et al. 2021

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Inflammatory cytokines produced at the site of disc herniation are considered as pain generators in patients with lumbar disc disease. Whether a high-sensitivity C-reactive protein (hs-CRP) assay can be used in order to predict the quantum of inflammation surrounding nerve roots is a matter of investigation. This study aimed to evaluate the association of hs-CRP level and functional outcomes measured by the Modified Oswestry Low Back Pain Disability Questionnaire (MODY) before and after epidural steroid injection (ESI) in patients with lumbar disc disease. Overview of Literature: Although many studies examining the role of hs-CRP levels and lumbar pain have been published previously, the results are equivocal, and there is no clear consensus regarding which patients will benefit from an ESI. Methods: This was a prospective study, with 77 patients in the study group and 23 participants in the control group. Baseline hs-CRP levels were obtained for both groups. Study group patients received a single ESI and were subjected to detailed pre-and postprocedure evaluation using MODY scores. For this group, hs-CRP levels were measured at 1 and 2 months after injection. Results: Out of 77 patients, 52 had acute and 25 had chronic low back pain. Thirty-six patients with acute pain obtained significant improvement, while 16 had an insignificant response to the ESI. None of the chronic cases had a significant response. The mean baseline hs-CRP (mg/L) among the study group (29.83±10.43) was significantly higher than for the controls (10.26±2.783). The baseline hs-CRP among acute cases, where post ESI MODY score at 2 months had significant reduction, was 32.19±5.126, and those with insignificant reduction was 18.13±7.949 (p<0.001). Conclusions: Baseline hs-CRP levels can be used to prognosticate the outcome following ESI in patients with acute lumbar disc disease, with radicular pain refractory to physiotherapy and analgesics.

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High sensitivity C-reactive protein in pre-eclamptic women living with HIV at a tertiary hospital in Zambia: a preliminary study

Kabaya,

Omar,

Kumwenda

et al. 2024

Pan Afr Med J

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Can hsCRP be the sole investigation for predicting the severity and outcome in women with pre-eclampsia presenting late in pregnancy?

Cited by 4 publications

References 1 publication

Longitudinal profile of high‐sensitivity C‐reactive protein in women with pre‐eclampsia

Longitudinal profile of high‐sensitivity C‐reactive protein in women with pre‐eclampsia

Can High-Sensitivity C-Reactive Protein Levels Predict Functional Outcome Following Epidural Steroid Injection in Patients with Lumbar Disc Disease?

High sensitivity C-reactive protein in pre-eclamptic women living with HIV at a tertiary hospital in Zambia: a preliminary study

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