Can leukocyte telomere length predict survival time in heart transplant recipients over a minimal follow-up of 20 years?

Dlouhá, Dana; Vančura, V.; Vymetalova, Jevgenija; Hubáček, J.; Lánská, Věra; Málek, I

doi:10.1016/j.atherosclerosis.2017.06.899

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, we genotyped, together with their donors, a unique set of 396 adult patients (aged 55.5 ± 11.9 years, 79% of males, followed up for 1 year) who underwent orthotopic heart transplantation at the Institute for Clinical and Experimental Medicine (Prague) between January 2005 and December 2015. Endomyocardial biopsies (at least 10) were performed as part of the routine surveillance of all recipients during the first year.…”

Section: Methodsmentioning

confidence: 99%

The fat mass and obesity related gene polymorphism influences the risk of rejection in heart transplant patients

Hubacek

Vymetalova

Lánská

et al. 2018

Clinical Transplantation

Self Cite

View full text Add to dashboard Cite

Heart transplantation is a relatively common treatment for end‐stage heart failure. The major complication of heart transplantation is organ rejection. Epigenetic could play a role in the pathogenesis of organ rejection, and the FTO gene is a mediator of DNA methylation. We analyzed a tagging FTO SNP rs17817449 in both donor and recipient DNA obtained through 370 heart transplantations. Recipient FTO genotypes were not associated with either type of rejection or with the general increase in the risk of rejection. When compared with patients without a history of rejection, carriers of transplanted hearts with the FTO TT genotype exhibited a significantly increased risk (P = 0.02) of suffering from both types of rejection in comparison to carriers of hearts with at least one G allele (OR; 95% CI = 2.56; 1.15‐5.69). Our results suggest that the donor, but not the recipient, FTO genotype could be a significant predictor of acute rejection in heart transplant patients.

show abstract

Section: Methodsmentioning

confidence: 99%

The fat mass and obesity related gene polymorphism influences the risk of rejection in heart transplant patients

Hubacek

Vymetalova

Lánská

et al. 2018

Clinical Transplantation

Self Cite

View full text Add to dashboard Cite

show abstract

“…Relative telomere length was analysed in leukocyte DNA isolated from whole frozen (at −80°C for less than 4 wk) EDTA blood. A quantitative polymerase chain reaction (qPCR)-based method described by Dlouha et al 7,8,9 ) was used. Briefly, analysis was performed in triplicate on the Rotor-Gene 3000 (Corbett Research, Ltd.) using oligonucleotides: telomere analysis 5′ GGT TTT TGA GGG TGA GGG TGA GGG TGA GGG TGA GGG T and 5′ TCC CGA CTA TCC CTA TCC CTA TCC CTA TCC CTA TCC CTA; single copy gene analysis 5′ CAG CAA GTG GGA AGG TGT AAT CC and 5′ CCC ATT CTA TCA TCA ACG GGT ACA A.…”

mentioning

confidence: 99%

Leukocyte telomere length is not affected by long-term occupational exposure to nano metal oxides

et al. 2019

Self Cite

View full text Add to dashboard Cite

The aim of this study was to ascertain whether long-term occupational exposure to nanoparticles would affect relative leukocyte telomere length (LrTL). We analysed occupational exposure to size-resolved aerosol particles, with special emphasis on nanoparticles at two workshops: i/ the production of nanocomposites containing metal oxides; ii/ laboratory to test experimental exposure of nano-CuO to rodents. Thirty five exposed researchers (age 39.5 ± 12.6 yr; exposure duration 6.0 ± 3.7 yr) and 43 controls (40.4 ± 10.5 yr) were examined. LrTL did not significantly (p=0.14) differ between the exposed researchers (0.92 ± 0.13) and controls (0.86 ± 0.15). In addition, no significant correlation (r=−0.22, p=0.22) was detected between the duration of occupational exposure and LrTL. The results remained non-significant after multiple adjustments for age, sex and smoking status. Our pilot results suggest that relative leukocyte telomere length is not affected by occupational exposure to nanoparticles.

show abstract

Can leukocyte telomere length predict survival time in heart transplant recipients over a minimal follow-up of 20 years?

Cited by 2 publications

References 0 publications

The fat mass and obesity related gene polymorphism influences the risk of rejection in heart transplant patients

The fat mass and obesity related gene polymorphism influences the risk of rejection in heart transplant patients

Leukocyte telomere length is not affected by long-term occupational exposure to nano metal oxides

Contact Info

Product

Resources

About