Can manic switches be predicted in pediatric major depression? A systematic literature review

Uchida, Mai; Serra, Giulia; Zayas, Lázaro V.; Kenworthy, Tara; Hughes, Brittany; Koster, Ariana; Faraone, Stephen V.; Biederman, Joseph

doi:10.1016/j.jad.2014.09.046

Cited by 27 publications

(18 citation statements)

References 39 publications

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“…A significant minority of children or youth with MDD will eventually go on to develop BD, with an average rate of 28% being reported 572, 573. Risk factors for switch to mania following a depressive episode include a family history of mood disorders, emotional and behavioural dysregulation, subthreshold manic symptoms, cyclothymia, atypical depression and psychosis 572.…”

Section: Specific Populationsmentioning

confidence: 99%

Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder

et al. 2018

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The Canadian Network for Mood and Anxiety Treatments (CANMAT) previously published treatment guidelines for bipolar disorder in 2005, along with international commentaries and subsequent updates in 2007, 2009, and 2013. The last two updates were published in collaboration with the International Society for Bipolar Disorders (ISBD). These 2018 CANMAT and ISBD Bipolar Treatment Guidelines represent the significant advances in the field since the last full edition was published in 2005, including updates to diagnosis and management as well as new research into pharmacological and psychological treatments. These advances have been translated into clear and easy to use recommendations for first, second, and third‐ line treatments, with consideration given to levels of evidence for efficacy, clinical support based on experience, and consensus ratings of safety, tolerability, and treatment‐emergent switch risk. New to these guidelines, hierarchical rankings were created for first and second‐ line treatments recommended for acute mania, acute depression, and maintenance treatment in bipolar I disorder. Created by considering the impact of each treatment across all phases of illness, this hierarchy will further assist clinicians in making evidence‐based treatment decisions. Lithium, quetiapine, divalproex, asenapine, aripiprazole, paliperidone, risperidone, and cariprazine alone or in combination are recommended as first‐line treatments for acute mania. First‐line options for bipolar I depression include quetiapine, lurasidone plus lithium or divalproex, lithium, lamotrigine, lurasidone, or adjunctive lamotrigine. While medications that have been shown to be effective for the acute phase should generally be continued for the maintenance phase in bipolar I disorder, there are some exceptions (such as with antidepressants); and available data suggest that lithium, quetiapine, divalproex, lamotrigine, asenapine, and aripiprazole monotherapy or combination treatments should be considered first‐line for those initiating or switching treatment during the maintenance phase. In addition to addressing issues in bipolar I disorder, these guidelines also provide an overview of, and recommendations for, clinical management of bipolar II disorder, as well as advice on specific populations, such as women at various stages of the reproductive cycle, children and adolescents, and older adults. There are also discussions on the impact of specific psychiatric and medical comorbidities such as substance use, anxiety, and metabolic disorders. Finally, an overview of issues related to safety and monitoring is provided. The CANMAT and ISBD groups hope that these guidelines become a valuable tool for practitioners across the globe.

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Section: Specific Populationsmentioning

confidence: 99%

Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder

et al. 2018

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“…While previous reviews have examined the development of BD in samples with depression, these have been unsystematic , limited to antidepressant‐associated switch or in samples under the age of 18 . Importantly, variability in follow‐up periods has not always been considered and is likely to impact on transition rate estimates.…”

Section: Introductionmentioning

confidence: 99%

A systematic review and meta‐analysis of prospective transition from major depression to bipolar disorder

Ratheesh

Davey

Hetrick

et al. 2017

Acta Psychiatr Scand

107

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“…The authors of this paper recently conducted a literature review examining which clinical correlates are most predictive of ultimate manic switches in children initially presenting with depressive episodes (Uchida et al, 2014). In their systematic literature review, the authors elucidated that manic switches in pediatric depression can be predicted by several risk factors, including positive family history of mood disorders, emotional and behavioral dysregulation, subthreshold mania, and psychosis.…”

Section: Introductionmentioning

confidence: 99%

Can unipolar and bipolar pediatric major depression be differentiated from each other? A systematic review of cross-sectional studies examining differences in unipolar and bipolar depression

Uchida

Serra

Zayas

et al. 2015

Journal of Affective Disorders

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Can manic switches be predicted in pediatric major depression? A systematic literature review

Cited by 27 publications

References 39 publications

Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder

Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder

A systematic review and meta‐analysis of prospective transition from major depression to bipolar disorder

Can unipolar and bipolar pediatric major depression be differentiated from each other? A systematic review of cross-sectional studies examining differences in unipolar and bipolar depression

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