Can neural stem cells be used to track down and destroy migratory brain tumor cells while also providing a means of repairing tumor-associated damage?

Noble, Mark

doi:10.1073/pnas.97.23.12393

Cited by 32 publications

(17 citation statements)

References 15 publications

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“…For example, immortalized cells from early postnatal neural precursors, genetically modified to overexpress interleukin-4, improved survival after inoculation into glioblastoma-bearing mice (Benedetti et al, 2000;Noble, 2000). Interestingly, however, the unmodified control cells in that study enhanced survival, too.…”

Section: Introductionmentioning

confidence: 87%

“…A recent study confirmed the effects on survival of in vitro expanded neural precursor cell lines administered into gliomas (Staflin et al, 2004). Currently, no gene therapy strategies have been approved for glioblastoma, and clinicians rely on the classic therapies, namely, surgery, chemotherapy, and cranial irradiation (Noble, 2000). However, glioblastomas cannot be completely removed by the classic therapies because of their high invasiveness, and the disease is therefore fatal within a short time (Kleihues et al, 1996;Holland, 2001).…”

Section: Introductionmentioning

confidence: 94%

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Glioblastoma-Induced Attraction of Endogenous Neural Precursor Cells Is Associated with Improved Survival

Glaß

Synowitz²,

Kronenberg³

et al. 2005

J. Neurosci.

193

172

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Neural precursor cells contribute to adult neurogenesis and to limited attempts of brain repair after injury. Here we report that in a murine experimental glioblastoma model, endogenous neural precursors migrate from the subventricular zone toward the tumor and surround it. The association of endogenous precursors with syngenic tumor grafts was observed, after injecting red fluorescent proteinlabeled G261 cells into the caudate-putamen of transgenic mice, which express green fluorescent protein under a promoter for nestin (nestin-GFP). Fourteen days after inoculation, the nestin-GFP cells surrounded the tumors in several cell layers and expressed markers of early noncommitted and committed precursors. Nestin-GFP cells were further identified by a characteristic membrane current pattern as recorded in acute brain slices. 5-Bromo-2-deoxyuridine labeling and dye tracing experiments revealed that the tumor-associated precursors originated from the subventricular zone. Moreover, in cultured explants from the subventricular zone, the neural precursors showed extensive tropism for glioblastomas. Tumor-induced endogenous precursor cell accumulation decreased with age of the recipient; this correlated with increased tumor size and shorter survival times in aged mice. Coinjection of glioblastoma cells with neural precursors improved the survival time of old mice to a level similar to that in young mice. Coculture experiments showed that neural precursors suppressed the rapid increase in tumor cell number, which is characteristic of glioblastoma, and induced glioblastoma cell apoptosis. Our results indicate that tumor cells attract endogenous precursor cells; the presence of precursor cells is antitumorigenic; and this cellular interaction decreases with aging.

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Section: Introductionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 94%

Glioblastoma-Induced Attraction of Endogenous Neural Precursor Cells Is Associated with Improved Survival

Glaß

Synowitz²,

Kronenberg³

et al. 2005

J. Neurosci.

193

172

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show abstract

“…Нåзàëåaeíî â³ä м³ñöя ââåäåííя, НСÊ мîãëè «â³äшó-êàòè» ³ äîñяãàëè êë³òèí ïóхëèíè мîзêó. Сâ³äчåííя ñòàб³ëüíî¿ åêñïðåñ³¿ НСÊ òðàíñãåí³â (êîíâåðòóючîãî åíзèмó öèòîзèíäåзàм³íàзè, HSV-òèм³äèíê³íàзè) íà ö³é мîäåë³ ï³äòâåðäèëî мîaeëèâ³ñòü ¿х âèêîðèñòàííя яê òåðàïåâòèчíèх зàñîб³â ïðè ïóхëèíàх мîзêó [22].…”

Section: огляäîâ³ ñòàòò³unclassified

“…Cхîae³ ðåзóëüòàòè îòðèмàí³ ï³ä чàñ äîñë³äaeåííя мèшåé з ³íòðàêðàí³àëüíîю мåäóëî-бëàñòîмîю -ââåäåí³ ãåíåòèчíî мîäèф³êîâàí³ НСÊ ëюäèíè ðîзòàшîâóâàëèñü íà мåae³ мàñè ïóхëèíè [17]. Нàâåäåí³ äàí³ äîзâîëяюòü ñïîä³âàòèñя íà âèêî-ðèñòàííя íîðмàëüíèх НСÊ яê òðàíñïîðòíèх зàñîб³â äëя ñåëåêòèâíî¿ äîñòàâêè ïðîòèïóхëèííèх ðåчîâèí ó зîíó ðîñòó ïóхëèíè [16,22].…”

Section: огляäîâ³ ñòàòò³unclassified

Antitumour properties of neural stem cells: possible application in brain tumour therapy

Lisyany¹,

Lyubych²

2009

Ukr Neurosurg J

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Lisyany N.I., Lyubych L.D. Institute of Neurosurgery named after A.P.Romodanov of the AMS of Ukraine, Kiev, Ukraine Up-to-date data on antitumour properties of neural stem (NSC) and progenitor cells and possibility of using them in brain tumour therapy are presented in the literature review. NSC potential for migration and tropism to brain tumours is described, as well as possible mechanisms of NSC antitumour properties.

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“…Нà åêñïåðèмåíòàëüíèх мîäåëях ðîñòó ãë³îм (N29, C6) ïîêàзàíî, щî íåéðàëüí³ ñòîâбóðîâ³ êë³-òèíè (НСÊ) ñåëåêòèâíî м³ãðóюòü äî òêàíèíè ïóхëèí ³ íàêîïèчóюòüñя íà мåae³ м³ae ïóхëèíîю ³ ³íòàêòíèмè êë³òèíàмè мîзêó [6,14,24]. Цå äîзâîëяє ñïîä³âàòèñя íà ïåðñïåêòèâí³ñòü âèêîðèñòàííя íîðмàëüíèх НСÊ яê âåêòîðíèх ñèñòåм äëя ñåëåêòèâíî¿ äîñòàâêè ïðî-òèïóхëèííèх ðåчîâèí ó зîíó ðîñòó ïóхëèíè [18].…”

Section: кëючîâ³ ñëîâà: прогеніторні нейроклітини гліоми людини проunclassified

Investigation of rat progenitor neural cells supernatant antitumor action on glioma cells in conditions of culture

Semenova¹,

Lyubych²,

Lisyany³

et al. 2008

Ukr Neurosurg J

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Can neural stem cells be used to track down and destroy migratory brain tumor cells while also providing a means of repairing tumor-associated damage?

Cited by 32 publications

References 15 publications

Glioblastoma-Induced Attraction of Endogenous Neural Precursor Cells Is Associated with Improved Survival

Glioblastoma-Induced Attraction of Endogenous Neural Precursor Cells Is Associated with Improved Survival

Antitumour properties of neural stem cells: possible application in brain tumour therapy

Investigation of rat progenitor neural cells supernatant antitumor action on glioma cells in conditions of culture

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