Can Neutrophil to Lymphocyte Ratio Be a Predictor Tool for The Non-Sentinel Lymph Node Metastasis in Breast Cancer?

Atak, İbrahim; Serkan, Yegen Fatih; Tuba, Atak; Bağcivan, Erol; Lütfi, Polat

doi:10.21614/chirurgia.114.1.83

Cited by 8 publications

(5 citation statements)

References 13 publications

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“…The low ratio of such a parameter might indicate a systemic background of reduced inflammation and immune system activation. The presence of a high NLR value has been recognized as a poor prognostic factor in various cancers, including breast cancer (1,(7)(8)(9)(10)(11)30). In the present study, we found that NLR was higher in breast carcinoma patients without lymphedema.…”

Section: Discussionsupporting

confidence: 62%

Are Peripheral Neutrophil-to-Lymphocyte Ratio and Platelet-toLymphocyte Radio Related with Breast Cancer-Related Lymphedema?

Analan¹,

Çetin²

2022

JEURMEDS

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Objective: To investigate peripheral neutrophil-lymphocyte ratio, which is an indicator of immunity and systemic inflammation, and platelet-lymphocyte ratio in patients with breast cancer and its affect on lymphedema. Material and Methods:The patients were dichotomized into two groups, ones with breast cancer-related lymphedema (BCRL) and the control group cases with no identified BCRL. The BCRL group included 28 cases and the control group included 34. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) values were compared between the groups. Intra and intergroup correlation analysis for NLR/PLR, visual analog scale (VAS), Quick Disabilities of the Arm, Shoulder, and Hand Questionnaire (Q-DASH), and the volumetric and diametric differences between the upper extremities were computed.Results: Neutrophil-to-lymphocyte ratio was significantly higher in the control group (p= 0.035). Platelet-to-lymphocyte ratio values yielded similar results (p= 0.161). There was no correlation between NLR/PLR values and outcome parameters (r≤ 0.3; p> 0.05). Conclusion:Neutrophil-to-lymphocyte ratio and PLR are not clinically significant for lymphedema, pain, disability, physical function, and BCRL.

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Section: Discussionsupporting

confidence: 62%

Are Peripheral Neutrophil-to-Lymphocyte Ratio and Platelet-toLymphocyte Radio Related with Breast Cancer-Related Lymphedema?

Analan¹,

Çetin²

2022

JEURMEDS

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“…28 Recent published studies on the correlation between neutrophil-to-lymphocyte ratio and breast cancer are listed in Table 1. [29][30][31][32][33][34] 1) NLR at baseline might be a significant indicator for efficacy of T-DM1.…”

Section: Neutrophil-to-lymphocyte Ratio (Nlr)mentioning

confidence: 99%

<p>The Research Progress on the Prognostic Value of the Common Hematological Parameters in Peripheral Venous Blood in Breast Cancer</p>

Chen

Kong

Yan

et al. 2020

OTT

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Breast carcinoma is one of the most malignant tumors, severely influencing the physical and mental health of people. The latest epidemiological and clinical studies have found that breast tumor and inflammation are determinate relationships with each other. Inflammation is an essential component of the tumor microenvironment, and the change of inflammatory cells might influence tumor progression, such as neoplastic cell proliferation, migration, invasion, the collapse of antitumor immunity, metastasis and so forth. Peripheral blood tests at the time of diagnosis and treatment can reflect inflammatory conditions within the neoplasm. Evaluation of peripheral blood parameters including white blood cell, neutrophil, lymphocyte, monocyte, platelet counts, as well as neutrophil-to-lymphocyte ratio (NLR), derived neutrophil-to-lymphocyte ratio (d-NLR) (neutrophil count divided by the result of white blood cell count minus neutrophil count), platelet-to-lymphocyte ratio (PLR) and lymphocyte-to-monocyte ratio (LMR), which are indicators of systematic inflammatory response, have been widely proposed as prognostic factors for many malignancies. To intensively study the relationship between the common markers in peripheral blood and the treatment or prognosis of breast cancer will have critical clinical significance and application prospect, and can provide useful information for the clinicians. Herein, we review the research progress in the prognostic role of the peripheral blood in breast cancer to provide a new method for the treatment and prognosis of breast cancer.

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“…Atak et al stated that the preoperative NLR is a valuable diagnostic tool for predicting non-SLN metastasis. [ 40 ] Ma et al [ 41 ] argued that it might be appropriate to use LMR as a prognostic marker in patients with breast cancer, and LMR is a better prognostic marker than NLR and PLR in predicting breast cancer prognosis.…”

Section: Discussionmentioning

confidence: 99%

Can inflammatory indices predict sentinel lymph node status in patients with early-stage breast cancer?

Balbaloglu,

Tasdoven,

Karadeniz Cakmak

2023

Medicine

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Breast cancer research has focused on the early detection and treatment of breast cancer. Axillary lymph node status is essential for primary breast cancer staging, recurrence, and survival. The current quest for precision medicine is to identify predictive markers that offer the advantage of individualized treatment options. This study aimed to investigate the value of inflammatory indices in predicting positive sentinel nodes in breast cancer. We studied 602 patients with early-stage breast cancer who underwent sentinel lymph node biopsies (SLNB) at the Bülent Ecevit University General Surgery Clinic. We obtained data, including the clinical and demographic characteristics of the patients, such as age, histological type, and sentinel lymph nodes. Neutrophil, lymphocyte, platelet, and monocyte counts were obtained from preoperative complete blood count test data from the patient registry. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), systemic inflammatory index (SII), and sentinel lymph node biopsy were analyzed. Sentinel LAP was negative in 391 (65%) patients and positive in 211 (35%). In the receiver operating characteristic curve analysis, no significant difference was found between SLNB positivity and negativity in terms of NLR, PLR, LMR, or SII. In contrast to previous research, NLR, PLR, LMR, or SII did not affect SLNB positivity prediction in our study.

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Can Neutrophil to Lymphocyte Ratio Be a Predictor Tool for The Non-Sentinel Lymph Node Metastasis in Breast Cancer?

Cited by 8 publications

References 13 publications

Are Peripheral Neutrophil-to-Lymphocyte Ratio and Platelet-toLymphocyte Radio Related with Breast Cancer-Related Lymphedema?

Are Peripheral Neutrophil-to-Lymphocyte Ratio and Platelet-toLymphocyte Radio Related with Breast Cancer-Related Lymphedema?

<p>The Research Progress on the Prognostic Value of the Common Hematological Parameters in Peripheral Venous Blood in Breast Cancer</p>

Can inflammatory indices predict sentinel lymph node status in patients with early-stage breast cancer?

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