CAN Optical Coherence Tomography  redefine amblyopia?

Avram, Elena

doi:10.22336/rjo.2017.18

Cited by 8 publications

(9 citation statements)

References 30 publications

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“…Some OCT studies have suggested few changes on OCT in these eyes. [123] Some observers have analyzed the changes in the macular thickness in different types of amblyopia at different distances from the center of the fovea with variable conclusions. Few studies have shown an increase in the foveolar thickness and decrease in the macular thickness away from the center in the amblyopic eyes as compared with normal/control eyes.…”

Section: Discussionmentioning

confidence: 99%

“…Few studies have shown an increase in the foveolar thickness and decrease in the macular thickness away from the center in the amblyopic eyes as compared with normal/control eyes. [13] Few authors have demonstrated a reduction in macular thickness after patching therapy. [4] Similarly, the retinal nerve fiber layer (RNFL) thickness around the peripapillary region in amblyopia has been studied with variable conclusions.…”

Section: Discussionmentioning

confidence: 99%

“…[6] Similarly, the subfoveal choroidal layer thickness of amblyopic eyes has been found to be increased without any definable cause. [3] The pediatric eye disease investigative group study states that there is no significant change in the RNFL thickness (globally or quadrant wise) in amblyopia. [6]…”

Section: Discussionmentioning

confidence: 99%

“…Few studies have evaluated these eyes using optical coherence tomography and have noted variable findings along the retino-choroidal layers. [1234] One study has also shown a statistically significant decrease in the vascular plexus density in eyes with amblyopia. [5] In this report, we intend to analyze the changes in vascular plexus density along the superficial vascular network in cases of strabismic amblyopia using a noninvasive modality that is optical coherence tomography angiography (OCTA) only.…”

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confidence: 99%

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Assessment of macular vascular plexus density using optical coherence tomography angiography in cases of strabismic amblyopia

Pujari

Chawla

Mukhija

et al. 2019

Indian J Ophthalmol

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Purpose: To evaluate the superficial retinal vascular plexus density using optical coherence tomography angiography (OCTA) in cases of strabismic amblyopia. Methods: Ten eyes of 10 patients with purely strabismic amblyopia underwent detailed ocular evaluation followed by the assessment of the superficial retinal plexus vascular density using OCTA (Topcon DRI OCT Triton, Swept Source OCT, Topcon, Japan). Ten contralateral normal eyes of the same patients were considered as control. All these 20 eyes underwent a 4.5 × 4.5 mm cube scan OCTA centered at the fovea. Using the Topcon propriety software all 20 eyes were assessed for the capillary plexus density of the superficial retinal vascular plexus along the superior, inferior, nasal, and temporal quadrants centered at the fovea. The numerical values were statistically assessed using a paired t -test with respect to each quadrant between the normal and the pathological eyes. Results: The average age of patients was 16 years and eight patients were males. The mean superficial retinal vascular plexus density along the superior, inferior, nasal, and temporal quadrants in normal and pathological eyes were 49.25 ± 30.34 and 48.93 ± 2.85, 47.22 ± 4.11 and 47.37 ± 4.8, 45.54 ± 1.55 and 43.81 ± 4.21, and 46.26 ± 4.63 and 46.38 ± 5.40, respectively. Similarly, the capillary densities along the central were 17.84 ± 3.49 and 17.24 ± 2.44 in normal and pathological eyes. The differences among all these four quadrants and central area were not statistically significant ( P -values > 0.05 for all four quadrants and central area) as compared with the normal eyes. Conclusion: The superficial retinal vascular plexus density of a 4.5 × 4.5 mm cube centered at the fovea of eyes of cases of strabismic amblyopia is similar to that of normal eyes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Assessment of macular vascular plexus density using optical coherence tomography angiography in cases of strabismic amblyopia

Pujari

Chawla

Mukhija

et al. 2019

Indian J Ophthalmol

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“…A study using OCT demonstrated that the subfoveal choroidal thickness (CT) is statistically the same in both AE and FE [20]. But contrary to these findings, other OCT studies have often shown that the subfoveal CT is increased in AE [21]. It is difficult to compare other OCT studies to ours since most of them studied thickness which, in many cases, does not affect the mean reflectivity of a given structure.…”

Section: Plos Onementioning

confidence: 73%

Morphological changes in amblyopic eyes in choriocapillaris and Sattler’s layer in comparison to healthy eyes, and in retinal nerve fiber layer in comparison to fellow eyes through quantification of mean reflectivity: A pilot study

et al. 2021

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Purpose Establishing the reliability of a new method to check the mean retinal and choroidal reflectivity and using it to find retinal and choroid changes in amblyopia. Methods Design: Retrospective case-control. Population: 28 subjects of which 10 were healthy controls (20 eyes): 8 with refractive errors, 1 with strabismus, and 1 with both. 18 patients with unilateral amblyopia included: 7 anisometropic, 6 isoametropic, 1 strabismic, and 4 combined. Mean participants’ age: 13.77 years ± 10.28. Observation procedures: SD-OCT and ImageJ. Main outcome measure: mean reflectivity of retinal and choroid layers. Amblyopic, fellow, and healthy eyes were compared. Results The method of measuring reflectivity is good to excellent reliability for all regions of interest except the fourth. The mean reflectivity of the choriocapillaris and Sattler’s layer in amblyopic eyes were significantly lower than in healthy eyes (p = 0.003 and p = 0.008 respectively). The RNFL reflectivity was lower than that of fellow eyes (p = 0.025). Post-hoc pairwise comparisons showed statistically significant differences between amblyopic and healthy eyes for choriocapillaris (p = 0.018) and Sattler’s (p = 0.035), and between amblyopic and fellow eyes for RNFL (p = 0.039). Conclusion A decrease in reflectivity of the choriocapillaris and Sattler’s in amblyopic compared to healthy eyes, and a decrease in reflectivity of the RNFL in the amblyopic compared to fellow eyes, indicate that the pathophysiology is partly peripheral and might be bilateral.

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Optical Coherence Tomography Angiography as an Important Diagnostic Tool for Amblyopia

Lim

Tan

2020

JAMA Ophthalmol

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CAN Optical Coherence Tomography redefine amblyopia?

Cited by 8 publications

References 30 publications

Assessment of macular vascular plexus density using optical coherence tomography angiography in cases of strabismic amblyopia

Assessment of macular vascular plexus density using optical coherence tomography angiography in cases of strabismic amblyopia

Morphological changes in amblyopic eyes in choriocapillaris and Sattler’s layer in comparison to healthy eyes, and in retinal nerve fiber layer in comparison to fellow eyes through quantification of mean reflectivity: A pilot study

Optical Coherence Tomography Angiography as an Important Diagnostic Tool for Amblyopia

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