Can parental consanguinity be a risk factor for the occurrence of nonsyndromic oral cleft?

Silva, Carolina Maia; Pereira, Marcos Bastos; Queiroz, Thaís Bernardes de; Neves, Lucimara Teixeira das

doi:10.1016/j.earlhumdev.2019.06.005

Cited by 17 publications

(9 citation statements)

References 18 publications

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“…For a long period of time, the genetic aspects related to the etiology of non‐syndromic orofacial cleft (NSOFC) have been studied. In addition to the investigative analysis of genes, other important factors need to be considered, such as parental consanguinity and family history (Freitas et al, 2012; Neves et al, 2019; Silva et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Family history in non‐syndromic orofacial clefts: Is there a pattern?

et al. 2021

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Objective To survey the frequency and pattern of family history for non‐syndromic orofacial clefts (NSOFC). Initial hypothesis: more complex forms have a higher frequency of positive family history. Materials and Methods A retrospective study was carried with 2,668 subjects with three different types of clefts (CL Group (cleft lip), CLP Group (cleft lip and palate), and CP group (cleft palate)); family history information was collected. The Chi‐square (X2) and Z‐test were used. Results A positive family history was found in 31% of the sample. The CLP Group had highest percentage and highest proportion of affected relatives, being these factors statistically significant when compared to the CP Group. Comparisons between the CLP Male and CL Male with CP Male were statistically significant. First‐degree kinship was the most frequently found. Conclusions The initial hypothesis was confirmed, subjects with CLP had the highest percentage of positive family history, the highest proportion of affected relatives and had more affected relatives in comparison with CP. It is more common to find affected relatives in the CLP Male and CL Male groups when compared with CP Male. CLP and CP groups present a pattern of occurrence of the type of cleft in the family.

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Section: Discussionmentioning

confidence: 99%

Family history in non‐syndromic orofacial clefts: Is there a pattern?

et al. 2021

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“…Reference [59] investigated whether there is an association between parental consanguinity and the occurrence of oral cleft in their children. A positive association rate (2.68%) was observed compared to the control group which showed only 0.79% of association.…”

Section: Environmental Factors Involved In Cleft Lip/palate Developmentmentioning

confidence: 99%

Genetic And Environmental Factors Involved In The Development Of Oral Malformations Such As Cleft Lip/Palate In Non-Syndromic Patients And Open Bite Malocclusion

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et al. 2020

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Among the most common malformations observed in the oral cavity are cleft lip/palate and malocclusions, being this last one considered by the World Health Organization, the third public health problem.Malocclusions include the anterior open bite, a change in the vertical plane, that can be of two types: dental anterior open bite and skeletal anterior open bite. Cleft lip and cleft palate are the most common congenital malformations at birth. These malformations result from a failure in the normal craniofacial development process, which requires the coordination of a complex series of events. From the embryological point of view, the cleft lip/palate is a consequence of the failure of the first superior branchial arch to complete fusion with the frontonasal process during pregnancy.All these malformations result from the interaction of both genetic and environmental factors. Among the environmental factors involved in the development of malocclusions are deleterious habits, mouth breathing and trauma. Several genes involved in the development of facial bones, muscles and teeth are also responsible for the development of malocclusions. In the same way, clefts development is a multifactorial trait where multiple genes are involved as well as environmental factor like alcohol consumption, tobacco, exposure to pesticides or toxic solvents, in a complex interaction.All these factors may jeopardize the normal functioning of the stomatognathic system and the consequent quality of life of the patient. The purpose of this study was to review the literature concerning the genetic and environmental aspects involved in the development of these malformations.

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“…Em relação à consanguinidade parental, diversos estudos apontaram associação positiva desse fator com a ocorrência de fissura labiopalatinas não sindrômica (RAVICHANDRAN et al, 2012;SABBAGH et al, 2015;SILVA et al, 2019). ou lábio e palato), forma de acometimento (completa ou incompleta) e lateralidade (direta ou esquerda, no caso das fissuras com envolvimento de lábio) (Tabela 1).…”

Section: Etiologia Das Fissuras Labiopalatinasunclassified

“…Para a análise do tipo de fissura encontrada nos parentes afetados, estas foram classificadas de acordo com Spina et al (1972) Tabela 19 -Tipo de fissura encontrada nos parentes dos indivíduos com FL/PNS, distribuídos de acordo com os 8 Subgrupos, sendo o tipo de fissura do parente afetado classificado de acordo com Spina et al (1972), modificada por Silva Filho et al (1992). e os fatores genéticos, os quais incluem histórico familial, genes específicos e consanguinidade parental (AQUINO, et al, 2011;MITCHELL et al, 2002;SILVA et al, 2019 Analisando a população Chinesa no que se refere as taxas de histórico familial positivo, verificamos que a frequência desta vertente do aspecto genético variou de 9,86% a 17,2% (ZENG et al, 2015;LI et al, 2016;NEOGI et al, 2017). (HOLDER et al, 1992;BEATY et al, 2001;ZAPATA et al, 2010;ABDOLLAHI-FAKHIM et al, 2015;REITER et al, 2015;MBUYI-MUSANZAYI et al, 2018 Quanto a análise do tipo de fissura do parente afetado, pelos mesmos motivos explicitados para o grau de parentesco, os casos de parentesco distante e sem informação precisaram ser excluídos.…”

Section: -Tipo De Fissura No Parente Afetadounclassified

Investigação do histórico familial entre sujeitos com diferentes tipos de fissuras orofaciais não sindrômicas

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Can parental consanguinity be a risk factor for the occurrence of nonsyndromic oral cleft?

Cited by 17 publications

References 18 publications

Family history in non‐syndromic orofacial clefts: Is there a pattern?

Family history in non‐syndromic orofacial clefts: Is there a pattern?

Genetic And Environmental Factors Involved In The Development Of Oral Malformations Such As Cleft Lip/Palate In Non-Syndromic Patients And Open Bite Malocclusion

Investigação do histórico familial entre sujeitos com diferentes tipos de fissuras orofaciais não sindrômicas

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